2 |
ИНСУЛТ КАСАЛЛИГИ РИВОЖЛАНИШИ ТАРИХИДА ШАРҚ ВА ҒАРБ ОЛИМЛАРИНИНГ ЎЗИГА ХОС ҚАРАШЛАРИ ... : PECULIARITIES OF EASTERN AND WESTERN SCIENTISTS IN THE HISTORY OF IN THE DEVELOPMENT OF STROKE ...
|
|
|
|
BASE
|
|
Show details
|
|
4 |
The neuronal migration hypothesis of dyslexia : a critical evaluation 30 years on
|
|
|
|
BASE
|
|
Show details
|
|
5 |
The neuronal migration hypothesis of dyslexia: a critical evaluation 30 years on
|
|
|
|
BASE
|
|
Show details
|
|
6 |
The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on
|
|
|
|
BASE
|
|
Show details
|
|
7 |
A novel therapeutic agent, sodium oxybate, improves dystonic symptoms via reduced network-wide activity
|
|
|
|
BASE
|
|
Show details
|
|
8 |
Clinicopathological associations in frontotemporal dementia ...
|
|
|
|
BASE
|
|
Show details
|
|
10 |
New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications
|
|
Chare, Leone, Neuroscience Research Australia, Faculty of Medicine, UNSW; Hodges, John R, Neuroscience Research Australia, Faculty of Medicine, UNSW; Leyton, Cristian E, Neuroscience Research Australia, Faculty of Medicine, UNSW; McGinley, Ciara, 3Pathology and 4Medicine, Sydney Medical School, The University of Sydney, Sydney, Australia; Tan, Rachel H, Neuroscience Research Australia, Faculty of Medicine, UNSW; Kril, Jillian J, 3Pathology and 4Medicine, Sydney Medical School, The University of Sydney, Sydney, Australia; Halliday, Glenda, Neuroscience Research Australia, Faculty of Medicine, UNSW. - 2014
|
|
Abstract:
Objective: To assess the impact of new clinical diagnostic criteria for frontotemporal dementia (FTD) syndromes, including primary progressive aphasias (PPA), on prior clinical diagnosis and to explore clinicopathological correlations.Methods: 178 consecutive neuropathologically-ascertained cases initially diagnosed with a FTD syndrome were collected through specialist programs: the Cambridge Brain Bank, UK and Sydney Brain Bank, Australia. 135 cases were re-classified using the revised diagnostic criteria into behavioral variant (bvFTD), semantic variant PPA (sv-PPA), nonfluent/agrammatic variant PPA (nfv-PPA) and logopenic variant PPA (lv-PPA). Pathological diagnoses included FTLD-tau, FTLD-TDP, FTLD-FUS, FTLD-UPS, FLTD-ni and Alzheimer’s disease (AD). Statistical analyses included χ2 tests, analyses of variance and discriminant statistics.Results: Comparison of the original and revised diagnosis revealed no change in 90% of bvFTD and sv-PPA cases. By contrast 51% of nfv-PPA cases were reclassified as lv-PPA, with apraxia of speech and sentence repetition assisting in differentiation. Previous patterns of pathology were confirmed, although more AD cases occurred in FTD syndromes (10% bvFTD, ~15% sv-PPA and ~30% nfv-PPA) than expected. AD was the dominant pathology (77%) of lv-PPA. Discriminant analyses revealed that object agnosia, phonologic errors and neuropsychiatric features differentiated AD from FTLD. Conclusion: This study provides pathological validation that the new criteria assist with separating PPA cases with AD pathology into the new lv-PPA syndrome, and found that a number of diagnostic clinical features (disinhibition, food preferences and naming) did not assist in discriminating the different FTD syndromes.
|
|
Keyword:
: behavioural variant frontotemporal dementia; Central Nervous System (FOR: 110903); Central Nervous System (RFCD: 320702); frontotemporal lobar degeneration; neuropathology; progressive non-fluent aphasia; semantic dementia
|
|
URL: http://handle.unsw.edu.au/1959.4/53778 https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12477/SOURCE01?view=true
|
|
BASE
|
|
Hide details
|
|
13 |
Codificación visual y semántica en la demencia tipo Alzheimer (EA) mediante los principios lingüisticos de coherencia, cohesión y ritmo
|
|
|
|
BASE
|
|
Show details
|
|
|
|