| 1 |
The persistence and evolutionary consequences of vestigial behaviours
|
|
|
|
BASE
|
|
Show details
|
|
|
| 2 |
Next-gen sequencing identifies non-coding variation disrupting miRNA-binding sites in neurological disorders
|
|
|
|
BASE
|
|
Show details
|
|
|
| 3 |
Hyperkinetic stereotyped movements in a boy with biallelic CNTNAP2 variants
|
|
|
|
BASE
|
|
Show details
|
|
|
| 4 |
Genomic imprinting as a window into human language evolution
|
|
|
|
BASE
|
|
Show details
|
|
|
| 5 |
The effects of genetic ancestry on elite sprint athlete status in the West African diaspora
|
|
|
|
BASE
|
|
Show details
|
|
|
| 7 |
Copy number variation screen identifies a rare de novo deletion at chromosome 15q13.1-13.3 in a child with language impairment
|
|
|
|
BASE
|
|
Show details
|
|
|
| 8 |
Genome-wide screening for DNA variants associated with reading and language traits
|
|
|
|
BASE
|
|
Show details
|
|
|
| 9 |
Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
|
|
Becker, Jessica; Czamara, Darina; Scerri, Tom S; Ramus, Franck; Csépe, Valéria; Talcott, Joel B; Stein, John; Morris, Andrew; Ludwig, Kerstin U; Hoffmann, Per; Honbolygó, Ferenc; Tóth, Dénes; Fauchereau, Fabien; Bogliotti, Caroline; Iannuzzi, Stéphanie; Chaix, Yves; Valdois, Sylviane; Billard, Catherine; George, Florence; Soares-Boucaud, Isabelle; Gérard, Christophe-Loïc; van der Mark, Sanne; Schulz, Enrico; Vaessen, Anniek; Maurer, Urs; Lohvansuu, Kaisa; Lyytinen, Heikki; Zucchelli, Marco; Brandeis, Daniel; Blomert, Leo; Leppänen, Paavo Ht; Bruder, Jennifer; Monaco, Anthony P; Müller-Myhsok, Bertram; Kere, Juha; Landerl, Karin; Nöthen, Markus M; Schulte-Körne, Gerd; Paracchini, Silvia; Peyrard-Janvid, Myriam; Schumacher, Johannes. - 2015
|
|
Abstract:
The work conducted at the WTCHG was supported by Wellcome Trust grants [076566/Z/05/Z] and [075491/Z/04]; the work in Zurich partly by an SNSF grant [32-108130]. We also thank MAF (Mutation Analysis core Facility) at the Karolinska Institute, Novum, Huddinge. The French part of the project was funded by Agence Nationale de la Recherche (ANR-06-NEURO-019-01 GENEDYS) and Ville de Paris. S Paracchini is a Royal Society University Research Fellow. D Czamara was supported by the Deutsche Forschungsgemeinschaft (German Research Foundation) within the framework of the Munich Cluster for Systems Neurology (EXC 1010 SyNergy). ; Dyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from understanding the molecular mechanisms leading to the disorder. Several candidate genes have been implicated in dyslexia, including DYX1C1, DCDC2, KIAA0319, and the MRPL19/C2ORF3 locus, each with reports of both positive and no replications. We generated a European cross-linguistic sample of school-age children - the NeuroDys cohort - that includes more than 900 individuals with dyslexia, sampled with homogenous inclusion criteria across eight European countries, and a comparable number of controls. Here, we describe association analysis of the dyslexia candidate genes/locus in the NeuroDys cohort. We performed both case-control and quantitative association analyses of single markers and haplotypes previously reported to be dyslexia-associated. Although we observed association signals in samples from single countries, we did not find any marker or haplotype that was significantly associated with either case-control status or quantitative measurements of word-reading or spelling in the meta-analysis of all eight countries combined. Like in other neurocognitive disorders, our findings underline the need for larger sample sizes to validate possibly weak genetic effects. ; Postprint ; Peer reviewed
|
|
Keyword:
Association study; BDY; Candidate genes; Dyslexia; QH426; QH426 Genetics; R; R Medicine; Spelling; Word-reading
|
|
URL: https://doi.org/10.1038/ejhg.2013.199
http://hdl.handle.net/10023/7885
|
|
BASE
|
|
Hide details
|
|
|
| 10 |
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment
|
|
|
|
BASE
|
|
Show details
|
|
|
| 11 |
Mosaic maternal ancestry in the Great Lakes region of East Africa
|
|
|
|
BASE
|
|
Show details
|
|
|
| 13 |
Differential allelic expression of SOS1 and hyperexpression of the activating SOS1 c.755C variant in a Noonan syndrome family
|
|
|
|
BASE
|
|
Show details
|
|
|
| 14 |
Reading and language disorders : the importance of both quantity and quality
|
|
|
|
BASE
|
|
Show details
|
|
|
| 15 |
Counselling uncertainty: genetics professionals' accounts of (non)directiveness and trust/distrust
|
|
|
|
BASE
|
|
Show details
|
|
|
| 16 |
Counselling uncertainty: genetics professionals' accounts of (non)directiveness and trust/distrust
|
|
|
|
BASE
|
|
Show details
|
|
|
| 17 |
Uniparental Genetic Heritage of Belarusians: Encounter of Rare Middle Eastern Matrilineages with a Central European Mitochondrial DNA Pool
|
|
|
|
BASE
|
|
Show details
|
|
|
| 18 |
Statistical issues in modelling the ancestry from Y-chromosome and surname data
|
|
|
|
BASE
|
|
Show details
|
|
|
| 19 |
A genetic-based HAC technique for parallel clustering of bilingual Malay-English corpora
|
|
|
|
BASE
|
|
Show details
|
|
|
| 20 |
The spatial and temporal dimensions of reflective questions in genetic counselling
|
|
|
|
BASE
|
|
Show details
|
|
|
|
|
