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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia. ...
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Sensitivity and specificity of an acoustic- and perceptual-based tool for assessing motor speech disorders in French: the MonPaGe -screening protocol
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In: ISSN: 0269-9206 ; EISSN: 1464-5076 ; Clinical Linguistics & Phonetics ; https://hal.archives-ouvertes.fr/hal-03099545 ; Clinical Linguistics & Phonetics, Taylor & Francis, In press, ⟨10.1080/02699206.2020.1865460⟩ (2021)
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Analysing spectral changes over time to identify articulatory impairments in dysarthria
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In: ISSN: 0001-4966 ; EISSN: 1520-8524 ; Journal of the Acoustical Society of America ; https://hal.archives-ouvertes.fr/hal-03099517 ; Journal of the Acoustical Society of America, Acoustical Society of America, 2021, 149 (2), pp.758 - 769. ⟨10.1121/10.0003332⟩ (2021)
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Neurocognitive course at two-year follow-up in the neurocognitive assessment in the metabolic and aging cohort (NAMACO) study. ...
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Analysing spectral changes over time to identify articulatory impairments in dysarthria
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In: ISSN: 0001-4966 ; Journal of the Acoustical Society of America, Vol. 149, No 2 (2021) pp. 758-769 (2021)
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Sensitivity and specificity of an acoustic- and perceptual-based tool for assessing motor speech disorders in French: the MonPaGe-screening protocol
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In: ISSN: 0269-9206 ; Clinical Linguistics and Phonetics (2021) pp. 1-16 (2021)
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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia.
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Sala, Arianna; Malpetti, Maura; Farsad, Mohsen; Lubian, Francesca; Magnani, Giuseppe; Frasca Polara, Giulia; Epiney, Jean-Benoit; Abutalebi, Jubin; Assal, Frédéric; Garibotto, Valentina; Perani, Daniela. - : Wiley, 2021. : Hum Brain Mapp, 2021
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Abstract:
Lifelong bilingualism is associated with delayed dementia onset, suggesting a protective effect on the brain. Here, we aim to study the effects of lifelong bilingualism as a dichotomous and continuous phenomenon, on brain metabolism and connectivity in individuals with Alzheimer's dementia. Ninety-eight patients with Alzheimer's dementia (56 monolinguals; 42 bilinguals) from three centers entered the study. All underwent an [18F]-fluorodeoxyglucose positron emission tomography (PET) imaging session. A language background questionnaire measured the level of language use for conversation and reading. Severity of brain hypometabolism and strength of connectivity of the major neurocognitive networks was compared across monolingual and bilingual individuals, and tested against the frequency of second language life-long usage. Age, years of education, and MMSE score were included in all above mentioned analyses as nuisance covariates. Cerebral hypometabolism was more severe in bilingual compared to monolingual patients; severity of hypometabolism positively correlated with the degree of second language use. The metabolic connectivity analyses showed increased connectivity in the executive, language, and anterior default mode networks in bilingual compared to monolingual patients. The change in neuronal connectivity was stronger in subjects with higher second language use. All effects were most pronounced in the left cerebral hemisphere. The neuroprotective effects of lifelong bilingualism act both against neurodegenerative processes and through the modulation of brain networks connectivity. These findings highlight the relevance of lifelong bilingualism in brain reserve and compensation, supporting bilingual education and social interventions aimed at usage, and maintenance of two or more languages, including dialects, especially crucial in the elderly people.
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Keyword:
Alzheimer disease; default mode network; fluorodeoxyglucose F18; multilingualism; positron‐emission tomography; RESEARCH ARTICLE; RESEARCH ARTICLES
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URL: https://doi.org/10.17863/CAM.77664
https://www.repository.cam.ac.uk/handle/1810/330222
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Neurocognitive course at 2-year follow-up in a Swiss cohort of people with well-treated HIV
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In: AIDS (2021)
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MonPaGe, un outil de screening francophone informatisé d’évaluation perceptive et acoustique des troubles moteurs de la parole (dysarthries, apraxie de la parole
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In: ISSN: 0034-222X ; Rééducation orthophonique ; https://halshs.archives-ouvertes.fr/halshs-02504027 ; Rééducation orthophonique, Ortho édition, 2020, 281, pp.171-197 (2020)
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Impairment of both languages in late bilinguals with dementia of the Alzheimer type
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Second language performances in elderly bilinguals and individuals with dementia: The role of L2 immersion
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Impairment of both languages in late bilinguals with dementia of the Alzheimer type
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Progressive Crossed-Apraxia of Speech as a First Manifestation of a Probable Corticobasal Degeneration
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Progressive Crossed-Apraxia of Speech as a First Manifestation of a Probable Corticobasal Degeneration
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In: ISSN: 0953-4180 ; Behavioural Neurology, Vol. 25, No 4 (2012) pp. 285-289 (2012)
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