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Pediatric traumatic brain injury: language outcomes and their relationship to the arcuate fasciculus.
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In: Brain Lang , 127 (3) 388 - 398. (2013) (2013)
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Pediatric traumatic brain injury: Language outcomes and their relationship to the arcuate fasciculus
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In: Brain and Language , 127 (3) 388 - 398. (2013) (2013)
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Endophenotypes of FOXP2: Dysfunction within the human articulatory network
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In: EUR J PAEDIATR NEURO , 15 (4) 283 - 288. (2011) (2011)
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Speaking with a single cerebral hemisphere: fMRI language organization after hemispherectomy in childhood
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In: BRAIN LANG , 106 (3) 195 - 203. (2008) (2008)
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Cortical abnormalities and language function in young patients with basal ganglia stroke
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In: NEUROIMAGE , 36 (2) 431 - 440. (2007) (2007)
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Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
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In: BRAIN , 127 1229 - 1236. (2004) (2004)
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Abstract:
It is widely assumed that following extensive damage to the left hemisphere sustained in early childhood, language functions are likely to reorganize and develop in the right hemisphere, especially if the lesion affects the classical Broca's or Wernicke's language areas. In the present study, functional MRI (fMRI) was used to examine language lateralization in 10 children and adolescents with intractable epilepsy who sustained an early lesion in the left hemisphere. Lesions were adjacent to or within anterior language cortex in five patients, while they were remote from both Broca's and Wernicke's areas in the remainder. A lateralization index was calculated on the basis of the number of voxels activated in the left and right inferior frontal gyri when performing a covert verb generation task. Only two patients were right-handed, suggesting a high incidence of functional reorganization for motor control in the remaining patients. Five out of 10 showed bilateral or right language lateralization, but lateralization could not be inferred from the proximity of lesions to classical language areas on an individual basis. Lesions in or near Broca's area were not associated with inter-hemispheric language reorganization in four out of five cases, but with perilesional activation within the damaged left hemisphere. Paradoxically, lesions remote from the classical language areas were associated with non-left language lateralization in four out of five cases. Finally, handedness, age at onset of chronic seizures, and site of EEG abnormality also showed no obvious association with language lateralization. In conclusion, it is difficult to infer intra- versus inter-hemispheric language reorganization on the basis of clinical observations in the presence of early pathology to the left hemisphere.
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Keyword:
ACTIVATION PATTERNS; cerebral dominance; CHILDHOOD APHASIA; DOMINANCE; early pathology; FOCAL BRAIN INJURY; FUNCTIONAL MRI; language; ORGANIZATION; POSITRON-EMISSION-TOMOGRAPHY; SPEECH LATERALIZATION; TEMPORAL-LOBE EPILEPSY; WADA TEST
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URL: http://discovery.ucl.ac.uk/7980/
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Cortical lateralization during verb generation: a combined ERP and fMRI study
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In: NEUROIMAGE , 22 (2) 665 - 675. (2004) (2004)
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| 8 |
Functional MRI abnormalities during covert speech associated with FOXP2 gene mutation
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In: Nature Neuroscience , 6 (11 ) pp.1230 - 1237 . (2003) (2003)
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Language fMRI abnormalities associated with FOXP2 gene mutation
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In: NAT NEUROSCI , 6 (11) 1230 - 1237. (2003) (2003)
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| 10 |
Cortical representation of language studied with event related potentials (ERPS) and functional magnetic resonance imaging (fMRI)
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In: J COGNITIVE NEUROSCI 89 - 89. (2002) (2002)
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| 11 |
Cortical representation of language studied with event related potentials (ERPS) and functional magnetic resonance imaging (fMRI)
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In: Presented at: UNSPECIFIED. (2002) (2002)
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| 12 |
MRI analysis of an inherited speech and language disorder: structural brain abnormalities.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2002)
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