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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 4 5 6 7 8 9 10...27 Hits 101 – 120 of 533 101 Deficiency ED5438 uncovers the FoxP³⁹⁵⁵ self-learning phenotype ... Mendoza, Ezequiel; Colomb, Julien; Rybak, Jürgen. - : Universität Regensburg, 2014 BASE Show details 102 The mutant line FoxP³⁹⁵⁵ was impaired in operant self- but not world-learning ... Mendoza, Ezequiel; Colomb, Julien; Rybak, Jürgen. - : Universität Regensburg, 2014 BASE Show details 103 Conceptual architecture of operant feedback loops ... Mendoza, Ezequiel; Colomb, Julien; Rybak, Jürgen. - : Universität Regensburg, 2014 BASE Show details 104 Subtle morphological alterations in the brains of FoxP³⁹⁵⁵ mutants ... Mendoza, Ezequiel; Colomb, Julien; Rybak, Jürgen. - : Universität Regensburg, 2014 BASE Show details 105 Drosophila FoxP Mutants Are Deficient in Operant Self-Learning ... Mendoza, Ezequiel; Colomb, Julien; Rybak, Jürgen. - : Universität Regensburg, 2014 BASE Show details 106 Drosophila FoxP full length isoform B is required for operant self-learning ... Mendoza, Ezequiel; Colomb, Julien; Rybak, Jürgen. - : Universität Regensburg, 2014 BASE Show details 107 Basal ganglia function, stuttering, sequencing, and repair in adult songbirds ... Kubikova, Lubica; Bosikova, Eva; Cvikova, Martina. - : Freie Universität Berlin, 2014 BASE Show details 108 A Social Event Leonard,Constance A. - 2014 BASE Show details 109 Basic principles for establishing word boundaries Kutsch Lojenga, Constance. - 2014 BASE Show details 110 Orthography and tone: a tone-system typology with implications for orthography development Kutsch Lojenga, Constance. - 2014 BASE Show details 111 NDRǓLÓ TONE READING ; Lecture des tons Bassani, Artema C.; Utuga, Mark; Onega, Eliyaza. - : SIL International, 2014 BASE Show details 112 Ndrǔló Lexicon Bassani, Artema C.; Utuga, Mark; Onega, Eliyaza. - : SIL International, 2014 BASE Show details 113 Kitabo sa Habhula Handika Kwamba ; The Kwamba Spelling Guide Nzogi, Richard; Mubulya A. Wilson; Kamihanda, Zadok. - : Kwamba/Lubwisi Language Development Association in cooperation with SIL International, 2014 BASE Show details 114 Ndrǔló nà nga zòwdha ; Booklet for learning the vowels in Ndrǔló ; Uganda ; Livret pour l’apprentissage des voyelles en Ndrǔló ; R.D.Congo Onega, Eliyaza. - : SIL International, 2014 BASE Show details 115 Basal ganglia function, stuttering, sequencing, and repair in adult songbirds Kubikova, Lubica; Bosikova, Eva; Cvikova, Martina. - : Nature Publishing Group, 2014 BASE Show details 116 Drosophila FoxP Mutants Are Deficient in Operant Self-Learning Mendoza, Ezequiel; Colomb, Julien; Rybak, Jürgen. - : Public Library of Science, 2014 BASE Show details 117 Mesure de l'efficacité du support palliatif C.COM dans deux cas d'aphasies sévères altérant la compréhension Pinet, Constance; Teyssier, Marion. - : Universite Claude Bernard Lyon 1 - Ecole d 'orthophonie, 2014 BASE Show details 118 Drosophila FoxP Mutants Are Deficient in Operant Self-Learning Mendoza, Ezequiel; Colomb, Julien; Rybak, Jürgen; Pflüger, Hans-Joachim; Zars, Troy; Scharff, Constance; Brembs, Björn. - 2014 Abstract: Intact function of the Forkhead Box P2 (FOXP2) gene is necessary for normal development of speech and language. This important role has recently been extended, first to other forms of vocal learning in animals and then also to other forms of motor learning. The homology in structure and in function among the FoxP gene members raises the possibility that the ancestral FoxP gene may have evolved as a crucial component of the neural circuitry mediating motor learning. Here we report that genetic manipulations of the single Drosophila orthologue, dFoxP, disrupt operant self-learning, a form of motor learning sharing several conceptually analogous features with language acquisition. Structural alterations of the dFoxP locus uncovered the role of dFoxP in operant self-learning and habit formation, as well as the dispensability of dFoxP for operant world-learning, in which no motor learning occurs. These manipulations also led to subtle alterations in the brain anatomy, including a reduced volume of the optic glomeruli. RNAi-mediated interference with dFoxP expression levels copied the behavioral phenotype of the mutant flies, even in the absence of mRNA degradation. Our results provide evidence that motor learning and language acquisition share a common ancestral trait still present in extant invertebrates, manifest in operant self-learning. This ‘deep’ homology probably traces back to before the split between vertebrate and invertebrate animals. Figure S2: Separating the genetic control groups still shows the RNAi effect in operant self-learning. Both genetic control lines show significant learning scores of 0.37 and above (t-tests against zero, elav/+: t = 2.26, p = 0.038; RNAi/+: t = 3.53, p = 0.004). In contrast, the flies from the strain in which the elav driver expressed the isoform B-specific RNAi construct in all neurons, fails to reach even half of the lowest control score with a PI of less than 0.17, which cannot be distinguished from a PI of zero (t-test against zero; t = 0.141, P = 0.166). Figure S3: Subtle morphological alterations in the brains of FoxP³⁹⁵⁵ mutants. a, Three-dimensional surface renderings of typical fly brains from wild type Canton S (a1) and FoxP³⁹⁵⁵ mutants (a2). In the online version, clicking on the reconstructions will activate the 3D features of the figure and allow for interactions with the object in space. The different neuropil areas can be selected in the pop-up menu. b, Quantitative volumetric analysis of eleven major neuropils (M – medulla, L – lobula, LP – lobula plate, MB – mushroom bodies, AL – antennal lobes, FB – fan-shaped body, OT – optic tubercle, EB – ellipsoid body, OG – optic glomeruli (purple in a), PB – protocerebral bridge, N – noduli) revealed a significant reduction in the volume of the optic glomeruli in FoxP³⁹⁵⁵ flies (Mann-Whitney U-Test, U = 2.0, p<0.002). The volume of the remaining neuropils (denoted PL – protocerebral lobes) did not differ significantly. Asterisk – significant difference with a Bonferroni-corrected level of p<0.004. Black stripes – median, boxes – 25–75% percentiles, whiskers – total range. Grey boxes indicate FoxP³⁹⁵⁵, white boxes Canton S. c, Principal Components Analysis of the volumetric data. Plotted are the factor loadings of the individual flies on the two first components. Colored bars indicate means and standard errors (PC). Factor loadings are significantly different between Canton S and Foxp³⁹⁵⁵ for PC1 (Mann-Whitney U-Test, U = 52.0, p<0.04), but fail to reach significance for PC2. Number of brains analyzed: 7 (Canton S) and 9 (Foxp³⁹⁵⁵). Figure S4: PCA on relative volume data with optic glomeruli excluded from the analysis. The general distribution of the individual fly brains remains roughly similar to the PCA on all data (Fig. 6), suggesting that the exclusion of the volume data from the optic glomeruli does not drastically alter the general picture of anatomical differences between the mutant and wild type flies also outside of the optic glomeruli. However, the ANOVA on the differences between the two groups now fails to reach significance, emphasizing the importance of the volume difference we found in the optic glomeruli. Keyword: 570 Biowissenschaften; 610 Medizin; Biologie; ddc:570; ddc:610 URL: http://figshare.com/articles/_Drosophila_FoxP_Mutants_Are_Deficient_in_Operant_Self_Learning/1084271 https://epub.uni-regensburg.de/31538/3/Figure_S4.eps https://epub.uni-regensburg.de/31538/2/Figure_S3.pdf https://epub.uni-regensburg.de/31538/1/Figure_S2.eps https://epub.uni-regensburg.de/31538/ BASE Hide details 119 Drosophila FoxP Mutants Are Deficient in Operant Self-Learning Mendoza, Ezequiel; Colomb, Julien; Raybak, Jürgen. - : Public Library of Science, 2014 BASE Show details 120 La efectividad de un diseño call para el aprendizaje del resumen en escolares Constance Silvia Gómez Veloso In: Literatura y Lingüística, Iss 30, Pp 182-207 (2014) (2014) BASE Show details Page: 1 2 3 4 5 6 7 8 9 10...27

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