| 1 |
A functional dissociation of the left frontal regions that contribute to single word production tasks
|
|
|
|
In: Neuroimage (2021)
|
|
BASE
|
|
Show details
|
|
|
| 2 |
Lesions that do or do not impair digit span: a study of 816 stroke survivors
|
|
|
|
In: Brain Commun (2021)
|
|
BASE
|
|
Show details
|
|
|
| 3 |
Damage to Broca’s area does not contribute to long-term speech production outcome after stroke
|
|
|
|
In: Brain (2021)
|
|
BASE
|
|
Show details
|
|
|
| 4 |
Brain regions that support accurate speech production after damage to Broca’s area
|
|
|
|
In: Brain Commun (2021)
|
|
Abstract:
Broca’s area in the posterior half of the left inferior frontal gyrus has traditionally been considered an important node in the speech production network. Nevertheless, recovery of speech production has been reported, to different degrees, within a few months of damage to Broca’s area. Importantly, contemporary evidence suggests that, within Broca’s area, its posterior part (i.e. pars opercularis) plays a more prominent role in speech production than its anterior part (i.e. pars triangularis). In this study, we therefore investigated the brain activation patterns that underlie accurate speech production following stroke damage to the opercular part of Broca’s area. By combining functional MRI and 13 tasks that place varying demands on speech production, brain activation was compared in (i) seven patients of interest with damage to the opercular part of Broca’s area; (ii) 55 neurologically intact controls; and (iii) 28 patient controls with left-hemisphere damage that spared Broca’s area. When producing accurate overt speech responses, the patients with damage to the left pars opercularis activated a substantial portion of the normal bilaterally distributed system. Within this system, there was a lesion-site-dependent effect in a specific part of the right cerebellar Crus I where activation was significantly higher in the patients with damage to the left pars opercularis compared to both neurologically intact and patient controls. In addition, activation in the right pars opercularis was significantly higher in the patients with damage to the left pars opercularis relative to neurologically intact controls but not patient controls (after adjusting for differences in lesion size). By further examining how right Crus I and right pars opercularis responded across a range of conditions in the neurologically intact controls, we suggest that these regions play distinct roles in domain-general cognitive control. Finally, we show that enhanced activation in the right pars opercularis cannot be explained by release from an inhibitory relationship with the left pars opercularis (i.e. dis-inhibition) because right pars opercularis activation was positively related to left pars opercularis activation in neurologically intact controls. Our findings motivate and guide future studies to investigate (i) how exactly right Crus I and right pars opercularis support accurate speech production after damage to the opercular part of Broca’s area and (ii) whether non-invasive neurostimulation to one or both of these regions boosts speech production recovery after damage to the opercular part of Broca’s area.
|
|
Keyword:
Original Article
|
|
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523882/
https://doi.org/10.1093/braincomms/fcab230
http://www.ncbi.nlm.nih.gov/pubmed/34671727
|
|
BASE
|
|
Hide details
|
|
|
| 5 |
Right cerebral motor areas that support accurate speech production following damage to cerebellar speech areas
|
|
|
|
In: Neuroimage Clin (2021)
|
|
BASE
|
|
Show details
|
|
|
| 6 |
Research on bilingualism as discovery science
|
|
|
|
In: Brain Lang (2021)
|
|
BASE
|
|
Show details
|
|
|
| 7 |
A Data-Based Approach for Selecting Pre- and Intra-Operative Language Mapping Tasks
|
|
|
|
In: Front Neurosci (2021)
|
|
BASE
|
|
Show details
|
|
|
| 8 |
Neuromodulatory Control and Language Recovery in Bilingual Aphasia: An Active Inference Approach
|
|
|
|
In: Behav Sci (Basel) (2020)
|
|
BASE
|
|
Show details
|
|
|
| 9 |
The Flipped Classroom: An Innovative Approach to Medical Education in Ophthalmology
|
|
|
|
In: J Acad Ophthalmol (2020)
|
|
BASE
|
|
Show details
|
|
|
| 10 |
Kagta Iwitkekne Parikwaki - Parantunka ; Dicionário Palikur-Português e Vocabulário Português-Palikur
|
|
|
|
BASE
|
|
Show details
|
|
|
| 11 |
Literacy for the 21st Century: A Balanced Approach, 3rd edition
|
|
|
|
BASE
|
|
Show details
|
|
|
| 12 |
Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss
|
|
|
|
BASE
|
|
Show details
|
|
|
| 13 |
Phase Relationships of Hydrous Alkalic Magmas at High Pressures: Production of Nepheline Hawaiitic to Mugearitic liquids by Amhibole-Dominated Fractional Crystallization within the Lithospheric Mantle
|
|
|
|
In: Journal of Petrology (2015)
|
|
BASE
|
|
Show details
|
|
|
| 14 |
Phase Relationships of Hydrous Alkalic Magmas at High Pressures: Production of Nepheline Hawaiitic to Mugearitic liquids by Amhibole-Dominated Fractional Crystallization within the Lithospheric Mantle
|
|
|
|
In: Journal of Petrology (2015)
|
|
BASE
|
|
Show details
|
|
|
| 15 |
Dissociating the semantic function of two neighbouring subregions in the left lateral anterior temporal lobe
|
|
|
|
BASE
|
|
Show details
|
|
|
| 16 |
Comparing language outcomes in monolingual and bilingual stroke patients
|
|
|
|
BASE
|
|
Show details
|
|
|
| 19 |
Matrix analytic methods with Markov decision processes for hydrological applications.
|
|
|
|
BASE
|
|
Show details
|
|
|
| 20 |
Dissecting the functional anatomy of auditory word repetition
|
|
|
|
BASE
|
|
Show details
|
|
|
|
|
