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Individual differences in sentence comprehension: A functional Magnetic Resonance Imaging investigation of syntactic and lexical processing demands ...
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Individual differences in sentence comprehension: A functional Magnetic Resonance Imaging investigation of syntactic and lexical processing demands ...
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Modulation of cortical activity during comprehension of familiar and unfamiliar text topics in speed reading and speed listening
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Identifying Autism from Neural Representations of Social Interactions: Neurocognitive Markers of Autism
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The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism ...
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The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism ...
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Inter-Regional Brain Communication and Its Disturbance in Autism
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The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism
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Abstract:
Personal pronouns, such as ‘I’ and ‘you’, require a speaker/listener to continuously re-map their reciprocal relation to their referent, depending on who is saying the pronoun. This process, called ‘deictic shifting’, may underlie the incorrect production of these pronouns, or ‘pronoun reversals’, such as referring to oneself with the pronoun ‘you’, which has been reported in children with autism. The underlying neural basis of deictic shifting, however, is not understood, nor has the processing of pronouns been studied in adults with autism. The present study compared the brain activation pattern and functional connectivity (synchronization of activation across brain areas) of adults with high-functioning autism and control participants using functional magnetic resonance imaging in a linguistic perspective-taking task that required deictic shifting. The results revealed significantly diminished frontal (right anterior insula) to posterior (precuneus) functional connectivity during deictic shifting in the autism group, as well as reliably slower and less accurate behavioural responses. A comparison of two types of deictic shifting revealed that the functional connectivity between the right anterior insula and precuneus was lower in autism while answering a question that contained the pronoun ‘you’, querying something about the participant’s view, but not when answering a query about someone else’s view. In addition to the functional connectivity between the right anterior insula and precuneus being lower in autism, activation in each region was atypical, suggesting over reliance on individual regions as a potential compensation for the lower level of collaborative interregional processing. These findings indicate that deictic shifting constitutes a challenge for adults with high-functioning autism, particularly when reference to one’s self is involved, and that the functional collaboration of two critical nodes, right anterior insula and precuneus, may play a critical role for deictic shifting by supporting an attention shift between oneself and others.
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Original Article
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URL: https://doi.org/10.1093/brain/awr151 http://brain.oxfordjournals.org/cgi/content/short/awr151v1
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The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism
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The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism
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Altering cortical connectivity: Remediation-induced changes in the white matter of poor readers
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Atypical frontal-posterior synchronization of Theory of Mind regions in autism during mental state attribution
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Individual differences in sentence comprehension: A functional magnetic resonance imaging investiagation of syntactic and lexical processing demands ...
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Individual differences in sentence comprehension: A functional magnetic resonance imaging investiagation of syntactic and lexical processing demands ...
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Individual Differences in Sentence Comprehension: A Functional Magnetic Resonance Imaging Investigation of Syntactic and Lexical Processing Demands
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Sentence comprehension in autism: thinking in pictures with decreased functional connectivity ...
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Sentence comprehension in autism: thinking in pictures with decreased functional connectivity ...
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