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Language networks in anophthalmia: maintained hierarchy of processing in 'visual' cortex.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; CrossRef (2012)
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Structural and functional abnormalities of the motor system in developmental stuttering.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2008)
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Structural and functional abnormalities of the motor system in developmental stuttering
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In: BRAIN , 131 50 - 59. (2008) (2008)
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Abstract:
Though stuttering is manifest in its motor characteristics, the cause of stuttering may not relate purely to impairments in the motor system as stuttering frequency is increased by linguistic factors, such as syntactic complexity and length of utterance, and decreased by changes in perception, such as masking or altering auditory feedback. Using functional and diffusion imaging, we examined brain structure and function in the motor and language areas in a group of young people who stutter. During speech production, irrespective of fluency or auditory feedback, the people who stuttered showed overactivity relative to controls in the anterior insula, cerebellum and midbrain bilaterally and underactivity in the ventral premotor, Rolandic opercular and sensorimotor cortex bilaterally and Heschls gyrus on the left. These results are consistent with a recent meta-analysis of functional imaging studies in developmental stuttering. Two additional findings emerged from our study. First, we found overactivity in the midbrain, which was at the level of the substantia nigra and extended to the pedunculopontine nucleus, red nucleus and subthalamic nucleus. This overactivity is consistent with suggestions in previous studies of abnormal function of the basal ganglia or excessive dopamine in people who stutter. Second, we found underactivity of the cortical motor and premotor areas associated with articulation and speech production. Analysis of the diffusion data revealed that the integrity of the white matter underlying the underactive areas in ventral premotor cortex was reduced in people who stutter. The white matter tracts in this area via connections with posterior superior temporal and inferior parietal cortex provide a substrate for the integration of articulatory planning and sensory feedback, and via connections with primary motor cortex, a substrate for execution of articulatory movements. Our data support the conclusion that stuttering is a disorder related primarily to disruption in the cortical and subcortical neural systems supporting the selection, initiation and execution of motor sequences necessary for fluent speech production.
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Keyword:
ACQUIRED APHASIA; AUDITORY-CORTEX; basal ganglia; diffusion tensor imaging; FMRI; functional imaging; INHERITED SPEECH; LANGUAGE DISORDER; PARKINSONS-DISEASE; POSITRON-EMISSION-TOMOGRAPHY; speech dysfluency; SPEECH PRODUCTION; SYLLABLE PRODUCTION; ventral premotor cortex
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URL: http://discovery.ucl.ac.uk/136423/
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| 4 |
Structural and functional abnormalities of the motor system in developmental stuttering
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In: In: (pp. pp. 50-59). (2008) (2008)
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| 5 |
Applying FSL to the FIAC data: model-based and model-free analysis of voice and sentence repetition priming.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; ISI Proceedings ; CrossRef (2006)
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| 6 |
Applying FSL to the FIAC data: model-based and model-free analysis of voice and sentence repetition priming.
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In: Hum Brain Mapp , 27 (5) pp. 380-391. (2006) (2006)
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| 7 |
Testing for dual brain processing routes in reading: a direct contrast of chinese character and pinyin reading using FMRI.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2002)
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