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Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
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In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
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Providing a parent-administered outcome measure in a bilingual family of a father and a mother of two adolescents with ASD: brief report.
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In: Developmental neurorehabilitation, vol 25, iss 2 (2022)
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Providing a parent-administered outcome measure in a bilingual family of a father and a mother of two adolescents with ASD: brief report.
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Pre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism.
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In: Molecular psychiatry, vol 26, iss 12 (2021)
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Concurrent Associations between Expressive Language Ability and Independence in Adolescents and Adults with Fragile X Syndrome.
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In: Brain sciences, vol 11, iss 9 (2021)
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Concurrent Associations between Expressive Language Ability and Independence in Adolescents and Adults with Fragile X Syndrome.
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In: Brain sciences, vol 11, iss 9 (2021)
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Expressive language development in adolescents with Down syndrome and fragile X syndrome: change over time and the role of family-related factors.
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In: Journal of neurodevelopmental disorders, vol 12, iss 1 (2020)
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A neurophysiological model of speech production deficits in fragile X syndrome.
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In: Brain communications, vol 2, iss 1 (2020)
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Screen time in 36-month-olds at increased likelihood for ASD and ADHD.
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Screen time in 36-month-olds at increased likelihood for ASD and ADHD.
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Molecular Biomarkers Predictive of Sertraline Treatment Response in Young Children With Autism Spectrum Disorder.
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The Relationship between Expressive Language Sampling and Clinical Measures in Fragile X Syndrome and Typical Development.
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In: Brain sciences, vol 10, iss 2 (2020)
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Metformin treatment in young children with fragile X syndrome.
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In: Molecular genetics & genomic medicine, vol 7, iss 11 (2019)
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A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.
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Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.
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In: Genetics in medicine : official journal of the American College of Medical Genetics, vol 21, iss 8 (2019)
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A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.
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Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
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Lombardo, Michael V; Pramparo, Tiziano; Gazestani, Vahid; Warrier, Varun; Bethlehem, Richard AI; Carter Barnes, Cynthia; Lopez, Linda; Lewis, Nathan E; Eyler, Lisa; Pierce, Karen; Courchesne, Eric
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In: Nature neuroscience, vol 21, iss 12 (2018)
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Abstract:
Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple coordinated blood leukocyte gene coexpression modules and the multivariate functional neuroimaging (fMRI) response to speech. Gene coexpression modules associated with the multivariate fMRI response to speech were different for all pairwise comparisons between typically developing toddlers and toddlers with ASD and poor versus good early language outcome. Associated coexpression modules were enriched in genes that are broadly expressed in the brain and many other tissues. These coexpression modules were also enriched in ASD-associated, prenatal, human-specific, and language-relevant genes. This work highlights distinctive neurobiology in ASD subtypes with different early language outcomes that is present well before such outcomes are known. Associations between neuroimaging measures and gene expression levels in blood leukocytes may offer a unique in vivo window into identifying brain-relevant molecular mechanisms in ASD.
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Keyword:
1.1 Normal biological development and functioning; 2.1 Biological and endogenous factors; Autism; Autism Spectrum Disorder; Brain; Brain Disorders; Brain Mapping; Child; Clinical Research; Cognitive Sciences; Female; Genetics; Humans; Infant; Intellectual and Developmental Disabilities (IDD); Language; Leukocytes; Magnetic Resonance Imaging; Male; Mental Health; Neuroimaging; Neurological; Neurology & Neurosurgery; Neurosciences; Pediatric; Preschool; Psychology; Speech; Transcriptome
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URL: https://escholarship.org/uc/item/2n39p5qz
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Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
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In: Nature neuroscience, vol 21, iss 12 (2018)
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Magnetoencephalographic Imaging of Auditory and Somatosensory Cortical Responses in Children with Autism and Sensory Processing Dysfunction.
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Investigation of autistic traits through strategic decision-making in games with adaptive agents.
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In: Scientific reports, vol 7, iss 1 (2017)
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