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White matter disconnectivity fingerprints causally linked to dissociated forms of alexia
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In: ISSN: 2399-3642 ; Communications Biology ; https://hal.umontpellier.fr/hal-03634907 ; Communications Biology, Nature Publishing Group, 2021, 4 (1), pp.1413. ⟨10.1038/s42003-021-02943-z⟩ (2021)
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Abstract:
International audience ; For over 150 years, the study of patients with acquired alexia has fueled research aimed at disentangling the neural system critical for reading. An unreached goal, however, relates to the determination of the fiber pathways that root the different visual and linguistic processes needed for accurate word reading. In a unique series of neurosurgical patients with a tumor close to the visual word form area, we combine direct electrostimulation and population-based streamline tractography to map the disconnectivity fingerprints characterizing dissociated forms of alexia. Comprehensive analyses of disconnectivity matrices establish similarities and dissimilarities in the disconnection patterns associated with pure, phonological and lexical-semantic alexia. While disconnections of the inferior longitudinal and posterior arcuate fasciculi are common to all alexia subtypes, disconnections of the long arcuate and vertical occipital fasciculi are specific to phonological and pure alexia, respectively. These findings provide a strong anatomical background for cognitive and neurocomputational models of reading.
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Keyword:
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; MESH: Adult; MESH: Alexia; MESH: Dyslexia; MESH: Female; MESH: Humans; MESH: Male; MESH: Middle Aged; MESH: Nerve Net; MESH: Reading; MESH: White Matter; MESH: Young Adult; Pure
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URL: https://doi.org/10.1038/s42003-021-02943-z
https://hal.umontpellier.fr/hal-03634907/document
https://hal.umontpellier.fr/hal-03634907/file/s42003-021-02943-z.pdf
https://hal.umontpellier.fr/hal-03634907
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| 2 |
Predictors of developmental dyslexia in European orthographies with varying complexity.
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In: ISSN: 0021-9630 ; EISSN: 1469-7610 ; Journal of Child Psychology and Psychiatry ; https://hal.archives-ouvertes.fr/hal-00965034 ; Journal of Child Psychology and Psychiatry, Wiley, 2013, 54 (6), pp.686-94. ⟨10.1111/jcpp.12029⟩ (2013)
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| 3 |
The visual attention span deficit in dyslexia is visual and not verbal.
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In: ISSN: 0010-9452 ; Cortex ; https://hal.archives-ouvertes.fr/hal-00965201 ; Cortex, Elsevier, 2012, 48 (6), pp.768-73. ⟨10.1016/j.cortex.2011.09.003⟩ (2012)
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| 4 |
Impaired letter-string processing in developmental dyslexia: what visual-to-phonology code mapping disorder?
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In: ISSN: 1076-9242 ; EISSN: 1099-0909 ; Dyslexia ; https://hal.archives-ouvertes.fr/hal-00965212 ; Dyslexia, Wiley, 2012, 18 (2), pp.77-93. ⟨10.1002/dys.1437⟩ (2012)
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| 5 |
Genetic Variants of FOXP2 and KIAA0319/TTRAP/THEM2 Locus Are Associated with Altered Brain Activation in Distinct Language-Related Regions
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In: ISSN: 0270-6474 ; EISSN: 1529-2401 ; Journal of Neuroscience ; https://hal-pasteur.archives-ouvertes.fr/pasteur-01580207 ; Journal of Neuroscience, Society for Neuroscience, 2012, 32 (3), pp.817 - 825. ⟨10.1523/JNEUROSCI.5996-10.2012⟩ (2012)
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| 6 |
A visual processing but no phonological disorder in a child with mixed dyslexia.
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In: ISSN: 0010-9452 ; Cortex ; https://hal.archives-ouvertes.fr/hal-00965218 ; Cortex, Elsevier, 2011, 47 (10), pp.1197-218. ⟨10.1016/j.cortex.2011.05.011⟩ (2011)
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| 7 |
From genes to behavior in developmental dyslexia.
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In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-00260019 ; Nature Neuroscience, Nature Publishing Group, 2006, 9 (10), pp.1213-7. ⟨10.1038/nn1772⟩ (2006)
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| 8 |
The role of sensorimotor impairments in dyslexia: a multiple case study of dyslexic children.
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In: ISSN: 1363-755X ; EISSN: 1467-7687 ; Developmental Science ; https://hal.archives-ouvertes.fr/hal-00260021 ; Developmental Science, Wiley, 2006, 9 (3), pp.237-55; discussion 265-9. ⟨10.1111/j.1467-7687.2006.00483.x⟩ (2006)
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| 9 |
Genes, brain, and cognition: a roadmap for the cognitive scientist.
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In: ISSN: 0010-0277 ; EISSN: 1873-7838 ; Cognition ; https://hal.archives-ouvertes.fr/hal-00260020 ; Cognition, Elsevier, 2006, 101 (2), pp.247-69. ⟨10.1016/j.cognition.2006.04.003⟩ (2006)
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| 10 |
Exploring dyslexics' phonological deficit I: lexical vs sub-lexical and input vs output processes.
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In: ISSN: 1076-9242 ; EISSN: 1099-0909 ; Dyslexia ; https://hal.archives-ouvertes.fr/hal-00260023 ; Dyslexia, Wiley, 2005, 11 (4), pp.253-68 (2005)
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| 11 |
Neurobiology of dyslexia: a reinterpretation of the data.
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In: ISSN: 0166-2236 ; EISSN: 1878-108X ; Trends in Neurosciences ; https://hal.archives-ouvertes.fr/hal-00242911 ; Trends in Neurosciences, Elsevier, 2004, 27 (12), pp.720-6. ⟨10.1016/j.tins.2004.10.004⟩ (2004)
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| 12 |
Should neuroconstructivism guide developmental research?
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In: ISSN: 1364-6613 ; Trends in Cognitive Sciences ; https://hal.archives-ouvertes.fr/hal-00260027 ; Trends in Cognitive Sciences, Elsevier, 2004, 8 (3), pp.100-1. ⟨10.1016/j.tics.2004.01.002⟩ (2004)
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| 13 |
Theories of developmental dyslexia: insights from a multiple case study of dyslexic adults.
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In: ISSN: 0006-8950 ; EISSN: 1460-2156 ; Brain - A Journal of Neurology ; https://hal.archives-ouvertes.fr/hal-00242741 ; Brain - A Journal of Neurology , Oxford University Press (OUP), 2003, 126 (Pt 4), pp.841-65 (2003)
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| 14 |
The relationship between motor control and phonology in dyslexic children.
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In: The Journal of Child Psychology and Psychiatry and Allied Disciplines ; https://hal.archives-ouvertes.fr/hal-00242668 ; The Journal of Child Psychology and Psychiatry and Allied Disciplines, 2003, 44 (5), pp.712-22 (2003)
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| 15 |
Developmental dyslexia: specific phonological deficit or general sensorimotor dysfunction?
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In: ISSN: 0959-4388 ; Current Opinion in Neurobiology ; https://hal.archives-ouvertes.fr/hal-00242672 ; Current Opinion in Neurobiology, Elsevier, 2003, 13 (2), pp.212-8 (2003)
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| 16 |
Outstanding questions about phonological processing in dyslexia.
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In: ISSN: 1076-9242 ; EISSN: 1099-0909 ; Dyslexia ; https://hal.archives-ouvertes.fr/hal-00242899 ; Dyslexia, Wiley, 2001, 7 (4), pp.197-216. ⟨10.1002/dys.205⟩ (2001)
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| 17 |
Dyslexia. Talk of two theories.
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In: ISSN: 0028-0836 ; EISSN: 1476-4679 ; Nature ; https://hal.archives-ouvertes.fr/hal-00242898 ; Nature, Nature Publishing Group, 2001, 412 (6845), pp.393-5. ⟨10.1038/35086683⟩ (2001)
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| 18 |
Articulator involvement in naming ; Test of the articulatory feedback hypothesis of naming
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| 19 |
Phonologic and lexical routes to reading ; A comparison of impaired, normal and superior readers
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| 20 |
Measuring phonological processing and phonological working memory in adults with developmental dyslexia
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Conway, Timothy W. - : University of Florida. : University of Florida ( [Gainesville, Fla.] )
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