| 1 |
Comparison of Frequency Transposition and Frequency Compression for People With Extensive Dead Regions in the Cochlea. ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 2 |
The effectiveness of 6 versus 12-months of dialectical behaviour therapy for borderline personality disorder: the feasibility of a shorter treatment and evaluating responses (FASTER) trial protocol.
|
|
|
|
In: BMC psychiatry, vol 18, iss 1 (2018)
|
|
BASE
|
|
Show details
|
|
|
| 3 |
Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years. ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 4 |
Evaluation of a Frequency-Lowering Algorithm for Adults With High-Frequency Hearing Loss. ...
|
|
|
|
BASE
|
|
Show details
|
|
|
| 5 |
Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years.
|
|
British Autism Study of Infant Siblings (BASIS) Team; Charman, Tony; Jones, Emily; Johnson, Mark; Gliga, Teea; Cheung, Celeste; Pasco, Greg; Slonims, Vicky; Green, Jonathan; Elsabbagh, Mayada; Pickles, Andrew; Wan, Ming Wai; Bedford, Rachael. - : Wiley, 2017. : J Child Psychol Psychiatry, 2017
|
|
Abstract:
BACKGROUND: There has been increasing interest in the potential for pre-emptive interventions in the prodrome of autism, but little investigation as to their effect. METHODS: A two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention. Fifty-four infants (28 intervention, 26 nonintervention) at familial risk of autism but not otherwise selected for developmental atypicality were assessed at 9-month baseline, 15-month treatment endpoint, and 27- and 39-month follow-up. PRIMARY OUTCOME: severity of autism prodromal symptoms, blind-rated on Autism Observation Schedule for Infants or Autism Diagnostic Observation Schedule 2nd Edition across the four assessment points. SECONDARY OUTCOMES: blind-rated parent-child interaction and child language; nonblind parent-rated communication and socialisation. Prespecified intention-to-treat analysis combined estimates from repeated measures within correlated regressions to estimate the overall effect of the infancy intervention over time. RESULTS: Effect estimates in favour of intervention on autism prodromal symptoms, maximal at 27 months, had confidence intervals (CIs) at each separate time point including the null, but showed a significant overall effect over the course of the intervention and follow-up period (effect size [ES] = 0.32; 95% CI 0.04, 0.60; p = .026). Effects on proximal intervention targets of parent nondirectiveness/synchrony (ES = 0.33; CI 0.04, 0.63; p = .013) and child attentiveness/communication initiation (ES = 0.36; 95% CI 0.04, 0.68; p = .015) showed similar results. There was no effect on categorical diagnostic outcome or formal language measures. CONCLUSIONS: Follow-up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent-child dyadic social communication over this period. We highlight the value of extended follow-up and repeat assessment for early intervention trials.
|
|
Keyword:
Autism Spectrum Disorder; British Autism Study of Infant Siblings (BASIS) Team; Child; Communication; Early Intervention; Education; Educational; Female; Health Care; Humans; Interpersonal Relations; Language Development; Longitudinal Studies; Male; Nonprofessional; Outcome Assessment; Parent-Child Relations; Parenting; Preschool; Prodromal Symptoms; Single-Blind Method
|
|
URL: https://doi.org/10.17863/CAM.39753
https://www.repository.cam.ac.uk/handle/1810/292592
|
|
BASE
|
|
Hide details
|
|
|
| 6 |
Interrater reliability of the new criteria for behavioral variant frontotemporal dementia.
|
|
|
|
In: Neurology, vol 80, iss 21 (2013)
|
|
BASE
|
|
Show details
|
|
|
| 7 |
Improvement of the comprehension of written information given to healthy volunteers in biomedical research: a single-blind randomized controlled study.
|
|
|
|
In: ISSN: 0767-3981 ; EISSN: 1472-8206 ; Fundamental and Clinical Pharmacology ; https://hal.archives-ouvertes.fr/hal-00281336 ; Fundamental and Clinical Pharmacology, Wiley, 2007, 21 (2), pp.207-14. ⟨10.1111/j.1472-8206.2007.00472.x⟩ (2007)
|
|
BASE
|
|
Show details
|
|
|
| 8 |
Clusters of cognitive and behavioral disorders clearly distinguish primary progressive aphasia from frontal lobe dementia, and Alzheimer's disease
|
|
|
|
BASE
|
|
Show details
|
|
|
| 9 |
A randomized control trial investigating the effect of presurgical orthopedics on feeding in infants with cleft lip and/or palate.
|
|
|
|
In: Cleft Palate Craniofac J , 44 (2) pp. 182-193. (2007) (2007)
|
|
BASE
|
|
Show details
|
|
|
| 10 |
The landscape and lexicon of blinding in randomized trials.
|
|
|
|
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; CrossRef (2002)
|
|
BASE
|
|
Show details
|
|
|
|
|
