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Context-Driven Automatic Subgraph Creation for Literature-Based Discovery
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In: Kno.e.sis Publications (2015)
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Context-Driven Automatic Subgraph Creation for Literature-Based Discovery
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In: Amit P. Sheth (2014)
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Context-Driven Automatic Subgraph Creation for Literature-Based Discovery
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In: Krishnaprasad Thirunarayan (2014)
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Matrix-based pairwise key establishment in wireless mesh networks using deployment knowledge
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Matrix-based pairwise key establishment with pre and post deployment knowledge for wireless mesh networks
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Computational evidence that frequency trajectory theory does not oppose but emerges from age-of-acquisition theory.
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In: ISSN: 0364-0213 ; EISSN: 1551-6709 ; Cognitive Science ; https://hal.archives-ouvertes.fr/hal-00965101 ; Cognitive Science, Wiley, 2012, 36 (8), pp.1499-531. ⟨10.1111/j.1551-6709.2012.01266.x⟩ (2012)
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Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain.
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Vernes, Sonja,; Oliver, Peter,; Spiteri, Elizabeth; Lockstone, Helen,; Puliyadi, Rathi; Taylor, Jennifer,; Ho, Joses; Mombereau, Cedric; Brewer, Ariel; Lowy, Ernesto; Nicod, Jérôme; Groszer, Matthias; Baban, Dilair; Sahgal, Natasha; Cazier, Jean-Baptiste; Ragoussis, Jiannis; Davies, Kay,; Geschwind, Daniel,; Fisher, Simon
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In: ISSN: 1553-7390 ; EISSN: 1553-7404 ; PLoS Genetics ; https://www.hal.inserm.fr/inserm-00715268 ; PLoS Genetics, Public Library of Science, 2011, 7 (7), pp.e1002145. ⟨10.1371/journal.pgen.1002145⟩ (2011)
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Abstract:
International audience ; Forkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. Heterozygous mutations of the human FOXP2 gene cause a monogenic speech and language disorder. Reduced functional dosage of the mouse version (Foxp2) causes deficient cortico-striatal synaptic plasticity and impairs motor-skill learning. Moreover, the songbird orthologue appears critically important for vocal learning. Across diverse vertebrate species, this well-conserved transcription factor is highly expressed in the developing and adult central nervous system. Very little is known about the mechanisms regulated by Foxp2 during brain development. We used an integrated functional genomics strategy to robustly define Foxp2-dependent pathways, both direct and indirect targets, in the embryonic brain. Specifically, we performed genome-wide in vivo ChIP-chip screens for Foxp2-binding and thereby identified a set of 264 high-confidence neural targets under strict, empirically derived significance thresholds. The findings, coupled to expression profiling and in situ hybridization of brain tissue from wild-type and mutant mouse embryos, strongly highlighted gene networks linked to neurite development. We followed up our genomics data with functional experiments, showing that Foxp2 impacts on neurite outgrowth in primary neurons and in neuronal cell models. Our data indicate that Foxp2 modulates neuronal network formation, by directly and indirectly regulating mRNAs involved in the development and plasticity of neuronal connections.
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Keyword:
[SDV.GEN]Life Sciences [q-bio]/Genetics; Biological; Developmental; Inbred C57BL; MESH: Animals; MESH: Brain; MESH: Cell Line; MESH: Chromatin Immunoprecipitation; MESH: Corpus Striatum; MESH: Forkhead Transcription Factors; MESH: Gene Expression Profiling; MESH: Gene Expression Regulation; MESH: Gene Regulatory Networks; MESH: Mice; MESH: Models; MESH: Mutation; MESH: Neurites; MESH: Oligonucleotide Array Sequence Analysis; MESH: Primary Cell Culture; MESH: Repressor Proteins; MESH: RNA; Messenger; Tumor
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URL: https://www.hal.inserm.fr/inserm-00715268/document
https://doi.org/10.1371/journal.pgen.1002145
https://www.hal.inserm.fr/inserm-00715268/file/journal.pgen.1002145.pdf
https://www.hal.inserm.fr/inserm-00715268
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ABSTRACT Long-Distance 802.11b Links: Performance Measurements and Experience ∗
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In: http://www.cs.wisc.edu/~sdsen/papers/2006dgpmeas.pdf
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Journal Homepage: www.ijcst.org
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In: http://www.ijcst.org/Volume5/Issue2/p2_5_2.pdf
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