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1	Association between sleep parameters and longitudinal shortening of telomere length
	Jin, Jeong-Hwa; Kwon, Hyuk Sung; Choi, Seong Hye...
	In: Aging (Albany NY) (2022)
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2	Relationships between [(18)F]-THK5351 Retention and Language Functions in Primary Progressive Aphasia
	Jeong, Hye Jin; Yoon, Cindy W; Seo, Seongho; Lee, Sang-Yoon; Suh, Mee Kyung; Seo, Ha-Eun; Kim, Woo-Ram; Lee, Hyon; Heo, Jae-Hyeok; Lee, Yeong-Bae; Park, Kee Hyung; Choi, Seong Hye; Ido, Tatsuo; Lee, Kyoung-Min; Noh, Young. - : Korean Neurological Association, 2019
	Abstract: BACKGROUND AND PURPOSE: There are three distinct subtypes of primary progressive aphasia (PPA): the nonfluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA). We sought to characterize the pattern of [(18)F]-THK5351 retention across all three subtypes and determine the topography of [(18)F]-THK5351 retention correlated with each neurolinguistic score. METHODS: We enrolled 50 participants, comprising 13 PPA patients (3 nfvPPA, 5 svPPA, and 5 lvPPA) and 37 subjects with normal cognition (NC) who underwent 3.0-tesla magnetic resonance imaging, [(18)F]-THK5351 positron-emission tomography scans, and detailed neuropsychological tests. The PPA patients additionally participated in extensive neurolinguistic tests. Voxel-wise and region-of-interest-based analyses were performed to analyze [(18)F]-THK5351 retention. RESULTS: The nfvPPA patients exhibited higher [(18)F]-THK5351 retention in the the left inferior frontal and precentral gyri. In svPPA patients, [(18)F]-THK5351 retention was elevated in the anteroinferior and lateral temporal cortices compared to the NC group (left>right). The lvPPA patients exhibited predominant [(18)F]-THK5351 retention in the inferior parietal, lateral temporal, and dorsolateral prefrontal cortices, and the precuneus (left>right). [(18)F]-THK5351 retention in the left inferior frontal area was associated with lower fluency scores. Comprehension was correlated with [(18)F]-THK5351 retention in the left temporal cortices. Repetition was associated with [(18)F]-THK5351 retention in the left inferior parietal and posterior temporal areas, while naming difficulty was correlated with retention in the left fusiform and temporal cortices. CONCLUSIONS: The pattern of [(18)F]-THK5351 retention was well matched with clinical and radiological findings for each PPA subtype, in agreement with the anatomical and functional location of each language domain.
	Keyword: Original Article
	URL: http://www.ncbi.nlm.nih.gov/pubmed/31591842 https://doi.org/10.3988/jcn.2019.15.4.527 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785468/
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