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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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La répétition immédiate du nom propre en allemand: enjeux textuels et argumentatifs. Hildesheim / Zürich / New York, Olms.
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In: https://halshs.archives-ouvertes.fr/halshs-01902993 ; 2018 (2018)
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Das Nachfeld im Deutschen: Theorie und Empirie. [Reihe Germanistische Linguistik 303]. Berlin/Boston, de Gruyter
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In: https://halshs.archives-ouvertes.fr/halshs-01903396 ; 2015 (2015)
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Simultaneous PET-MRI Studies of the Concordance of Atrophy and Hypometabolism in Syndromic Variants of Alzheimer's Disease and Frontotemporal Dementia: An Extended Case Series.
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In: J Alzheimers Dis , 46 (3) pp. 639-653. (2015) (2015)
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Genetic contributions to variation in general cognitive function: A meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
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Davies, G; Armstrong, N; Bis, JC; Bressler, J; Chouraki, V; Giddaluru, S; Hofer, E; Ibrahim-Verbaas, CA; Kirin, M; Lahti, J; Van Der Lee, SJ; Le Hellard, S; Liu, T; Marioni, RE; Oldmeadow, C; Postmus, I; Smith, AV; Smith, JA; Thalamuthu, A; Thomson, R; Vitart, V; Wang, J; Yu, L; Zgaga, L; Zhao, W; Boxall, R; Harris, SE; Hill, WD; Liewald, DC; Luciano, M; Adams, H; Ames, D; Amin, N; Amouyel, P; Assareh, AA; Au, R; Becker, JT; Beiser, A; Berr, C; Bertram, L; Boerwinkle, E; Buckley, BM; Campbell, H; Corley, J; De Jager, PL; Dufouil, C; Eriksson, JG; Espeseth, T; Faul, JD; Ford, I; Scotland, G; Gottesman, RF; Griswold, ME; Gudnason, V; Harris, TB; Heiss, G; Hofman, A; Holliday, EG; Huffman, J; Kardia, SLR; Kochan, N; Knopman, DS; Kwok, JB; Lambert, JC; Lee, T; Li, G; Li, SC; Loitfelder, M; Lopez, OL; Lundervold, AJ; Lundqvist, A; Mather, KA; Mirza, SS; Nyberg, L; Oostra, BA; Palotie, A; Papenberg, G; Pattie, A; Petrovic, K; Polasek, O; Psaty, BM; Redmond, P; Reppermund, S; Rotter, JI; Schmidt, H; Schuur, M; Schofield, PW; Scott, RJ; Steen, VM; Stott, DJ; Van Swieten, JC; Taylor, KD; Trollor, J; Trompet, S; Uitterlinden, AG; Weinstein, G; Widen, E; Windham, BG; Jukema, JW; Wright, AF. - 2015
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Abstract:
General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10-9, MIR2113; rs17522122, P=2.55 × 10-8, AKAP6; rs10119, P=5.67 × 10-9, APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10-6). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ∼1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10-17). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.
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Keyword:
06 Biological Sciences; 11 Medical and Health Sciences; 17 Psychology and Cognitive Sciences
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URL: https://doi.org/10.1038/mp.2014.188
http://handle.unsw.edu.au/1959.4/unsworks_13655
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| 8 |
Measurement of the muon reconstruction performance of the ATLAS detector using 2011 and 2012 LHC proton-proton collision data.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2014)
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Genome-wide screening for DNA variants associated with reading and language traits.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2014)
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Les ‘centres anticipateurs’ dans les théories du Centrage: modèle grammatical vs. modèle fonctionnel
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In: ISSN: 0182-5887 ; Verbum (Presses Universitaires de Nancy) ; https://halshs.archives-ouvertes.fr/halshs-03475205 ; Verbum (Presses Universitaires de Nancy), Université de Nancy II, 2012, pp. 99-130 (2012)
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Les ‘centres anticipateurs’ dans les théories du Centrage: modèle grammatical vs. modèle fonctionnel, pp. 99-130
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In: ISSN: 0182-5887 ; Verbum (Presses Universitaires de Nancy) ; https://halshs.archives-ouvertes.fr/halshs-01903406 ; Verbum (Presses Universitaires de Nancy), Université de Nancy II, 2012 (2012)
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| 12 |
Wortstellungsvariation und Salienz von Diskursreferenten: Die Besetzung des Nachfeldes in deutschen Pressetexten als kohärenzstiftendes Mittel, 378-405
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In: ISSN: 0301-3294 ; EISSN: 1613-0626 ; Zeitschrift für Germanistische Linguistik ; https://halshs.archives-ouvertes.fr/halshs-03475213 ; Zeitschrift für Germanistische Linguistik, De Gruyter, 2011 (2011)
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De la linéarisation marquée à la cohérence du discours: l’après-dernière position (Nachfeld) en allemand contemporain, pp. 189-207
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In: ISSN: 1623-6742 ; EISSN: 2271-2852 ; Syntaxe et Sémantique ; https://halshs.archives-ouvertes.fr/halshs-01903401 ; Syntaxe et Sémantique, Presses Universitaires de Caen, 2011 (2011)
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Wortstellungsvariation und Salienz von Diskursreferenten: Die Besetzung des Nachfeldes in deutschen Pressetexten als kohärenzstiftendes Mittel, 378-405
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In: ISSN: 0301-3294 ; EISSN: 1613-0626 ; Zeitschrift für Germanistische Linguistik ; https://halshs.archives-ouvertes.fr/halshs-01903403 ; Zeitschrift für Germanistische Linguistik, De Gruyter, 2011 (2011)
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| 15 |
Blogging and Emergent L2 Literacy Development in an Urban Elementary School: A Functional
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In: http://digitalcommons.brockport.edu/cgi/viewcontent.cgi?article%3D1001%26context%3Dehd_facpub (2011)
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Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratio.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2011)
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| 17 |
LR19 - alienable and inalienable possession ; 0059-LR19 - alienable and inalienable possession
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LC; SP; EG. - : Clair Hill, 2008
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LR12 - two funny stories ; 0059-LR12 - two funny stories
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MB; EG; SP. - : Clair Hill, 2008
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LR16 - art, abstract design and visual perception ; 0059-LR16 - art, abstract design and visual perception
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MB; EG. - : Clair Hill, 2008
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