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61
The anterior temporal lobes are critically involved in acquiring new conceptual knowledge: Evidence for impaired feature integration in semantic dementia☆
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62
Capturing multidimensionality in stroke aphasia: mapping principal behavioural components to neural structures
Butler, Rebecca A.; Lambon Ralph, Matthew A.; Woollams, Anna M.. - : Oxford University Press, 2014
Abstract: Stroke aphasia is a multidimensional disorder in which patient profiles reflect variation along multiple behavioural continua. We present a novel approach to separating the principal aspects of chronic aphasic performance and isolating their neural bases. Principal components analysis was used to extract core factors underlying performance of 31 participants with chronic stroke aphasia on a large, detailed battery of behavioural assessments. The rotated principle components analysis revealed three key factors, which we labelled as phonology, semantic and executive/cognition on the basis of the common elements in the tests that loaded most strongly on each component. The phonology factor explained the most variance, followed by the semantic factor and then the executive-cognition factor. The use of principle components analysis rendered participants’ scores on these three factors orthogonal and therefore ideal for use as simultaneous continuous predictors in a voxel-based correlational methodology analysis of high resolution structural scans. Phonological processing ability was uniquely related to left posterior perisylvian regions including Heschl’s gyrus, posterior middle and superior temporal gyri and superior temporal sulcus, as well as the white matter underlying the posterior superior temporal gyrus. The semantic factor was uniquely related to left anterior middle temporal gyrus and the underlying temporal stem. The executive-cognition factor was not correlated selectively with the structural integrity of any particular region, as might be expected in light of the widely-distributed and multi-functional nature of the regions that support executive functions. The identified phonological and semantic areas align well with those highlighted by other methodologies such as functional neuroimaging and neurostimulation. The use of principle components analysis allowed us to characterize the neural bases of participants’ behavioural performance more robustly and selectively than the use of raw assessment scores or diagnostic classifications because principle components analysis extracts statistically unique, orthogonal behavioural components of interest. As such, in addition to improving our understanding of lesion–symptom mapping in stroke aphasia, the same approach could be used to clarify brain–behaviour relationships in other neurological disorders.
Keyword: Original Articles
URL: https://doi.org/10.1093/brain/awu286
http://brain.oxfordjournals.org/cgi/content/short/137/12/3248
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63
Time- but not sleep-dependent consolidation promotes the emergence of cross-modal conceptual representations
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64
Time- but not sleep-dependent consolidation promotes the emergence of cross-modal conceptual representations
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65
Capturing multidimensionality in stroke aphasia: mapping principal behavioural components to neural structures
Butler, Rebecca A.; Lambon Ralph, Matthew A.; Woollams, Anna M.. - : Oxford University Press, 2014
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66
The anterior temporal lobes support residual comprehension in Wernicke’s aphasia
Robson, Holly; Zahn, Roland; Keidel, James L.. - : Oxford University Press, 2014
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67
Going beyond inferior prefrontal involvement in semantic control: Evidence for the additional contribution of dorsal angular gyrus and posterior middle temporal cortex
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68
Domain-specific control of semantic cognition: A dissociation within patients with semantic working memory deficits
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 27 (2013) 6, 740-764
OLC Linguistik
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69
Using in vivo probabilistic tractography to reveal two segregated dorsal ‘language-cognitive’ pathways in the human brain
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 127 (2013) 2, 230-240
OLC Linguistik
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70
The Role of Sleep Spindles and Slow-Wave Activity in Integrating New Information in Semantic Memory
Tamminen, Jakke; Lambon Ralph, Matthew A.; Lewis, Penelope A.. - : Society for Neuroscience, 2013
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71
The role of sleep spindles and slow-wave activity in integrating new information in semantic memory
Tamminen, Jakke; Lambon Ralph, Matthew A.; Lewis, Penelope A.. - : Society for Neuroscience, 2013
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72
Demonstrating the Qualitative Differences between Semantic Aphasia and Semantic Dementia: A Novel Exploration of Nonverbal Semantic Processing
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73
The roles of the “ventral” semantic and “dorsal” pathways in conduite d'approche: a neuroanatomically-constrained computational modeling investigation
Ueno, Taiji; Lambon Ralph, Matthew A.. - : Frontiers Media S.A., 2013
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74
Repetition priming of picture naming in semantic aphasia: the impact of intervening items
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 26 (2012) 1, 44-63
BLLDB
OLC Linguistik
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75
How does linguistic knowledge contribute to short-term memory? Contrasting effects of impaired semantic knowledge and executive control
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 26 (2012) 3-4, 383-403
BLLDB
OLC Linguistik
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76
Facilitating and disrupting speech perception in word deafness
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 26 (2012) 2, 177-198
BLLDB
OLC Linguistik
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77
Posterior middle temporal gyrus is involved in verbal and non-verbal semantic cognition: evidence from rTMS
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 26 (2012) 9, 1119-1130
BLLDB
OLC Linguistik
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78
Case series, neuroscience-infused, computational neuropsychology will play a crucial role in the future of aphasiology : commentary on Laine and Martin, "Cognitive neuropsychology has been, is, and will be significant to aphasiology"
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 26 (2012) 11, 1381-1386
BLLDB
OLC Linguistik
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79
Errorless learning and rehabilitation of language and memory impairments
Lambon Ralph, Matthew A. (Hrsg.); Conroy, Paul (Hrsg.). - London [u.a.] : Routledge, 2012
BLLDB
UB Frankfurt Linguistik
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80
Posterior middle temporal gyrus is involved in verbal and non-verbal semantic cognition: Evidence from rTMS
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