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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 4 5...10 Hits 1 – 20 of 191 1 Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke Williams, Louise R.; Ali, Myzoon; VandenBerg, Kathryn... In: Research outputs 2014 to 2021 (2022) BASE Show details 2 Training flexible conceptual retrieval in post-stroke aphasia Stampacchia, Sara; Smallwood, Jonathan; Thompson, Hannah E.. - 2021 BASE Show details 3 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. ... Peterson, Katie A; Jones, P Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 4 Auditory beat perception is related to speech output fluency in post-stroke aphasia ... Stefaniak, James D.; Lambon Ralph, Matthew A.; De Dios Perez, Blanca. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 5 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool ... Peterson, Katie A.; Jones, P. Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 6 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool Peterson, Katie A.; Jones, P. Simon; Patel, Nikil... In: Front Aging Neurosci (2021) BASE Show details 7 Training flexible conceptual retrieval in post-stroke aphasia Hallam, Glyn P.; Nathaniel, Upasana; Lambon Ralph, Matthew A.... In: ISSN: 0960-2011 ; Neuropsychological Rehabilitation (2021) pp. 1-27 (2021) BASE Show details 8 Auditory beat perception is related to speech output fluency in post-stroke aphasia Stefaniak, James D.; Lambon Ralph, Matthew A.; De Dios Perez, Blanca. - : Nature Publishing Group UK, 2021. : Scientific Reports, 2021 BASE Show details 9 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool Peterson, Katie A.; Jones, P. Simon; Patel, Nikil; Tsvetanov, Kamen A.; Ingram, Ruth; Cappa, Stefano F.; Lambon Ralph, Matthew A.; Patterson, Karalyn; Garrard, Peter; Rowe, James B.. - : Frontiers Media S.A., 2021. : Frontiers in Aging Neuroscience, 2021 Abstract: Background: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) affect speech and language as well as motor functions. Clinical and neuropathological data indicate a close relationship between these two disorders and the non-fluent variant of primary progressive aphasia (nfvPPA). We use the recently developed Mini Linguistic State Examination tool (MLSE) to study speech and language disorders in patients with PSP, CBS, and nfvPPA, in combination with structural magnetic resonance imaging (MRI). Methods: Fifty-one patients (PSP N = 13, CBS N = 19, nfvPPA N = 19) and 30 age-matched controls completed the MLSE, the short form of the Boston Diagnostic Aphasia Examination (BDAE), and the Addenbrooke’s Cognitive Examination III. Thirty-eight patients and all controls underwent structural MRI at 3 Tesla, with T1 and T2-weighted images processed by surface-based and subcortical segmentation within FreeSurfer 6.0.0 to extract cortical thickness and subcortical volumes. Morphometric differences were compared between groups and correlated with the severity of speech and language impairment. Results: CBS and PSP patients showed impaired MLSE performance, compared to controls, with a similar language profile to nfvPPA, albeit less severe. All patient groups showed reduced cortical thickness in bilateral frontal regions and striatal volume. PSP and nfvPPA patients also showed reduced superior temporal cortical thickness, with additional thalamic and amygdalo-hippocampal volume reductions in nfvPPA. Multivariate analysis of brain-wide cortical thickness and subcortical volumes with MLSE domain scores revealed associations between performance on multiple speech and language domains with atrophy of left-lateralised fronto-temporal cortex, amygdala, hippocampus, putamen, and caudate. Conclusions: The effect of PSP and CBS on speech and language overlaps with nfvPPA. These three disorders cause a common anatomical pattern of atrophy in the left frontotemporal language network and striatum. The MLSE is a short clinical screening tool that can identify the language disorder of PSP and CBS, facilitating clinical management and patient access to future clinical trials. Keyword: aphasia; corticobasal syndrome; language; Neuroscience; progressive supranuclear palsy; speech URL: https://www.repository.cam.ac.uk/handle/1810/326597 https://doi.org/10.17863/CAM.74046 BASE Hide details 10 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. Peterson, Katie A; Jones, P Simon; Patel, Nikil... In: essn: 1663-4365 ; nlmid: 101525824 (2021) BASE Show details 11 The neural bases of resilient semantic system: evidence of variable neuro-displacement in cognitive systems Jung, Je Young; Rice, Grace E.; Lambon Ralph, Matthew A. In: Brain Struct Funct (2021) BASE Show details 12 Multiple dimensions underlying the functional organization of the language network Hodgson, Victoria J.; Lambon Ralph, Matthew A.; Jackson, Rebecca L. In: Neuroimage (2021) BASE Show details 13 Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia. Ingram, Ruth U; Halai, Ajay D; Pobric, Gorana... In: Brain : a journal of neurology, vol 143, iss 10 (2020) BASE Show details 14 RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia Brady, Marian C.; Ali, Myzoon; VandenBerg, Kathryn... In: Research outputs 2014 to 2021 (2020) BASE Show details 15 Bipartite Functional Fractionation within the Default Network Supports Disparate Forms of Internally Oriented Cognition Chiou, Rocco; Humphreys, Gina F; Lambon Ralph, Matthew A In: Cereb Cortex (2020) BASE Show details 16 RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia Brady, Marian C.; Ali, Myzoon; VandenBerg, Kathryn. - : Taylor & Francis, 2020 BASE Show details 17 A unified neurocomputational bilateral model of spoken language production in healthy participants and recovery in poststroke aphasia Chang, Ya-Ning; Lambon Ralph, Matthew A. In: Proc Natl Acad Sci U S A (2020) BASE Show details 18 Investigating the effect of changing parameters when building prediction models in post-stroke aphasia Halai, Ajay D.; Woollams, Anna M.; Lambon Ralph, Matthew A. In: Nat Hum Behav (2020) BASE Show details 19 Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes Murley, Alexander G; Coyle-Gilchrist, Ian; Rouse, Matthew A... In: Brain (2020) BASE Show details 20 Establishing two principal dimensions of cognitive variation in logopenic progressive aphasia Ramanan, Siddharth; Roquet, Daniel; Goldberg, Zoë-Lee... In: Brain Commun (2020) BASE Show details Page: 1 2 3 4 5...10

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