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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium
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In: Alzheimers Dement (2020)
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BILINGUALISM DELAYS EXPRESSION OF ALZHEIMER’S CLINICAL SYNDROME
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In: Dement Geriatr Cogn Disord (2020)
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Brain Structure in Bilingual Compared to Monolingual Individuals with Alzheimer’s Dementia: Proof of Concept
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In: J Alzheimers Dis (2020)
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Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630161 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018)
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Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia
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Bergeron, David; Gorno-Tempini, Maria,; Rabinovici, Gil,; Santos-Santos, Miguel,; Seeley, William; Miller, Bruce,; Pijnenburg, Yolande; Keulen, M Antoinette; Groot, Colin; Van Berckel, Bart,; Van Der Flier, Wiesje,; Scheltens, Philip; Rohrer, Jonathan,; Warren, Jason,; Schott, Jonathan,; Fox, Nick,; Sánchez-Valle, Raquel; Grau-Rivera, Oriol; Gelpi, Ellen; Seelaar, Harro; Papma, Janne,; Van Swieten, John,; Hodges, John,; Leyton, Cristian,; Piguet, Olivier; Rogalski, Emily,; Mesulam, Marsel,; Koric, Lejla; Nora, Kristensen; Pariente, Jeéreémie; Dickerson, Bradford; Mackenzie, Ian,; Hsiung, Ging-Yuek,; Belliard, Serge; Irwin, David,; Wolk, David,; Grossman, Murray; Jones, Matthew; Harris, Jennifer; Mann, David; Snowden, Julie,; Chrem-Mendez, Patricio; Calandri, Ismael,; Amengual, Alejandra,; Miguet-Alfonsi, Carole; Magnin, Eloi; Magnani, Giuseppe; Santangelo, Roberto; Deramecourt, Vincent; Pasquier, Florence; Mattsson, Niklas; Nilsson, Christer; Hansson, Oskar; Keith, Julia; Masellis, Mario; Black, Sandra,; Matías-Guiu, Jordi,; Cabrera-Martin, María-Nieves; Paquet, Claire; Dumurgier, Julien; Teichmann, Marc; Sarazin, Marie; Bottlaender, Michel; Dubois, Bruno; Rowe, Christopher,; Villemagne, Victor,; Vandenberghe, Rik; Granadillo, Elias; Teng, Edmond; Mendez, Mario; Meyer, Philipp,; Frings, Lars; Lleó, Alberto; Blesa, Rafael; Fortea, Juan; Seo, Sang Won; Diehl-Schmid, Janine; Grimmer, Timo; Frederiksen, Kristian Steen; Sánchez-Juan, Pascual; Chételat, Gaël; Jansen, Willemijn; Bouchard, Rémi,; Laforce, Robert Jr; Visser, Pieter Jelle; Ossenkoppele, Rik
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://www.hal.inserm.fr/inserm-02749861 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018)
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Abstract:
International audience ; Objective: To estimate the prevalence of amyloid positivity, defined by positron emission tomography (PET)/cerebrospinal fluid (CSF) biomarkers and/or neuropathological examination, in primary progressive aphasia (PPA) variants.Methods: We conducted a meta-analysis with individual participant data from 1,251 patients diagnosed with PPA (including logopenic [lvPPA, n = 443], nonfluent [nfvPPA, n = 333], semantic [svPPA, n = 401], and mixed/unclassifiable [n = 74] variants of PPA) from 36 centers, with a measure of amyloid-β pathology (CSF [n = 600], PET [n = 366], and/or autopsy [n = 378]) available. The estimated prevalence of amyloid positivity according to PPA variant, age, and apolipoprotein E (ApoE) ε4 status was determined using generalized estimating equation models.Results: Amyloid-β positivity was more prevalent in lvPPA (86%) than in nfvPPA (20%) or svPPA (16%; p < 0.001). Prevalence of amyloid-β positivity increased with age in nfvPPA (from 10% at age 50 years to 27% at age 80 years, p < 0.01) and svPPA (from 6% at age 50 years to 32% at age 80 years, p < 0.001), but not in lvPPA (p = 0.94). Across PPA variants, ApoE ε4 carriers were more often amyloid-β positive (58.0%) than noncarriers (35.0%, p < 0.001). Autopsy data revealed Alzheimer disease pathology as the most common pathologic diagnosis in lvPPA (76%), frontotemporal lobar degeneration-TDP-43 in svPPA (80%), and frontotemporal lobar degeneration-TDP-43/tau in nfvPPA (64%).Interpretation: This study shows that the current PPA classification system helps to predict underlying pathology across different cohorts and clinical settings, and suggests that age and ApoE genotype should be considered when interpreting amyloid-β biomarkers in PPA patients. Ann Neurol 2018;84:737-748.
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Keyword:
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
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URL: https://doi.org/10.1002/ana.25333
https://www.hal.inserm.fr/inserm-02749861
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The Progressive Acalculia Presentation of Parietal Variant Alzheimer’s Disease
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Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia
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Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia: Amyloid-β Pathology in PPA
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In: Annals of Neurology. - 84, 5 (2018) , 729-740, ISSN: 0364-5134 (2018)
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Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening.
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In: BMC geriatrics, vol 16, iss 1 (2016)
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Additional file 2: Table S2. of Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening ...
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Additional file 1: Table S1. of Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening ...
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Additional file 3: Table S3. of Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening ...
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Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening ...
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Additional file 3: Table S3. of Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening ...
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Additional file 1: Table S1. of Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening ...
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Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening ...
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Additional file 2: Table S2. of Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening ...
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Bilingualism in older Mexican-American immigrants is associated with higher scores on cognitive screening
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