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Simple Search
Hits 1 – 19 of 19
1
Genetic Structure of IQ, Phonemic Decoding Skill, and Academic Achievement
Lazaroo, Nikita K.
;
Bates, Timothy C.
;
Hansell, Narelle K.
. - : Frontiers Media S.A., 2019
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2
Genetic structure of IQ, phonemic decoding skill, and academic achievement
Lazaroo, Nikita K.
;
Bates, Timothy C.
;
Hansell, Narelle K.
. - : Frontiers Research Foundation, 2019
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3
Genome-wide screening for DNA variants associated with reading and language traits
Gialluisi, Alessandro
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Newbury, Dianne F
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Wilcutt, Erik G
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Olson, Richard K
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DeFries, John C
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Brandler, William M
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Pennington, Bruce F
;
Smith, Shelley D
;
Scerri, Thomas S
;
Simpson, Nuala H
;
The SLI Consortium
;
Luciano, Michelle
;
Evans, David M
;
Bates, Timothy C
;
Stein, John F
;
Talcott, Joel B
;
Monaco, Anthony P
;
Paracchini, Silvia
;
Francks, Clyde
;
Fisher, Simon E
. - 2015
Abstract:
This research was funded by: Max Planck Society, the University of St Andrews - Grant Number: 018696, US National Institutes of Health - Grant Number: P50 HD027802, Wellcome Trust - Grant Number: 090532/Z/09/Z, and Medical Research Council Hub Grant Grant Number: G0900747 91070 ; Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome‐wide association scan (GWAS) meta‐analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading‐ and language‐related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10–7 for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on‐going international efforts to identify genes contributing to reading and language skills. ; Publisher PDF ; Peer reviewed
Keyword:
BDC
;
BF
;
BF Psychology
;
CLDRC
;
Developmental dyslexia
;
GWAS
;
Language
;
Meta-analysis
;
Pleiotropic variants
;
QH426
;
QH426 Genetics
;
Reading
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Reading disability
;
SLIC
;
Specific language impairment
URL:
http://hdl.handle.net/10023/6497
https://onlinelibrary.wiley.com/doi/full/10.1111/gbb.12158#support-information-section
https://doi.org/10.1111/gbb.12158
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4
Genetic variance in a component of the language acquisition device: ROBO1 polymorphisms associated with phonological buffer deficits
Bates, Timothy C.
;
Luciano, Michelle
;
Medland, Sarah E.
. - : Springer, 2011
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5
Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample
Lind, Penelope A
;
Luciano, Michelle
;
Wright, Margaret J
. - : Nature Publishing Group, 2010
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6
Dyslexia and DCDC2: Normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample
Lind, Penelope A.
;
Luciano, Michelle
;
Wright, Margaret J.
. - : Nature Publishing Group, 2010
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7
Genes for a component of the language acquisition mechanism: ROBO1 polymorphisms associated with phonological buffer deficits
Bates, Timothy C.
;
Luciano, Michelle
;
Montgomery, Grant W.
. - : Springer New York LLC, 2010
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8
Genetic covariation between the author recognition test and reading and verbal abilities: What can we learn from the analysis of high performance?
Martin, Nicolas W.
;
Hansell, Narelle K.
;
Wainwright, Mark A.
. - : Springer New York, 2009
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9
Genetic and environmental bases of reading and spelling : a unified genetic dual route model
Luciano, Michelle
;
Martin, Nicholas G.
;
Castles, Anne
...
In:
Reading and writing. - New York, NY : Springer Science+Business Media
20 (2007) 1-2, 147-171
BLLDB
OLC Linguistik
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10
Genetic and environmental bases of reading and spelling : a unified genetic dual route model
Bates, Timothy C
;
Castles, Anne
;
Luciano, Michelle
. - : Springer Netherlands, 2007
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11
The ongoing adaptive evolution of ASPM and microcephalin is not explained by increased intelligence
Mekel-Bobrov, Nitzan
;
Posthuma, Danielle
;
Gilbert, Sandra L.
. - : Oxford University Press, 2007
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12
Genetic and environmental bases of reading and spelling: a unified genetic dual route model
Bates, Timothy C.
;
Castles, Anne
;
Luciano, Michelle
. - : Springer Netherlands, 2007
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13
Genetic architecture of language: Phonological and lexical storage capacity deficits in specific language impairment & dyslexia
Bates, Timothy C.
;
Luciano, Michelle
;
Wright, Margaret J.
. - : SPRINGER, 2007
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14
John Marshall and the developmental dyslexias
Coltheart, Max
;
Bates, Timothy C.
;
Castles, Anne
In:
Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group
20 (2006) 9-11, 871-892
BLLDB
OLC Linguistik
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15
John Marshall and the developmental dyslexias
Castles, Anne
;
Bates, Timothy C
;
Coltheart, Max
. - : Psychology Press, 2006
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16
The effects of local and global processing demands on perception and action
Hughes, Laura E.
;
Bates, Timothy C.
;
Davies, Anne M.Aimola
In:
Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science
59 (2005) 1, 71-81
OLC Linguistik
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17
Behaviour genetic analyses of reading and spelling: a component processes approach
Bates, Timothy C.
;
Castles, Anne
;
Coltheart, Max
. - : John Wiley & Sons, 2004
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18
Crystallized intelligence as a product of speed and drive for experience : the relationship of inspection time and openness to g and Gc
Bates, Timothy C
;
Shieles, Alexandra
. - : Elsevier, 2003
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19
Intelligence arguments and Australian psychology: a reply to Stankov and an alternative view
Bates, Timothy, C.
;
Stough, Con
In: Australian Psychologist, Vol. 35, no. 1 (Mar 2000), pp. 68-72 (2000)
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