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1
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020
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2
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020
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3
Task-Free Functional Language Networks: Reproducibility and Clinical Application
In: J Neurosci (2020)
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4
Test-Retest Reliability of Diffusion Measures Extracted Along White Matter Language Fiber Bundles Using HARDI-Based Tractography
Boukadi, Mariem; Marcotte, Karine; Bedetti, Christophe. - : Frontiers Media S.A., 2019
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5
Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review
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6
The Role of the Left Anterior Temporal Lobe for Unpredictable and Complex Mappings in Word Reading
Joyal, Marilyne; Brambati, Simona M.; Laforce, Robert J.. - : Frontiers Media S.A., 2017
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7
Semantic dementia and persisting Wernicke's aphasia: linguistic and anatomical profiles
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 117 (2011) 1, 28-33
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8
Sound naming in neurodegenerative disease
In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 72 (2010) 3, 423-429
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9
Sound Naming in Neurodegenerative Disease
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10
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2010
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11
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2010
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12
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2009
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13
The neural basis of surface dyslexia in semantic dementia
Abstract: Semantic dementia (SD) is a neurodegenerative disease characterized by atrophy of anterior temporal regions and progressive loss of semantic memory. SD patients often present with surface dyslexia, a relatively selective impairment in reading low-frequency words with exceptional or atypical spelling-to-sound correspondences. Exception words are typically ‘over-regularized’ in SD and pronounced as they are spelled (e.g. ‘sew’ is pronounced as ‘sue’). This suggests that in the absence of sufficient item-specific knowledge, exception words are read by relying mainly on subword processes for regular mapping of orthography to phonology. In this study, we investigated the functional anatomy of surface dyslexia in SD using functional magnetic resonance imaging (fMRI) and studied its relationship to structural damage with voxel-based morphometry (VBM). Five SD patients and nine healthy age-matched controls were scanned while they read regular words, exception words and pseudowords in an event-related design. Vocal responses were recorded and revealed that all patients were impaired in reading low-frequency exception words, and made frequent over-regularization errors. Consistent with prior studies, fMRI data revealed that both groups activated a similar basic network of bilateral occipital, motor and premotor regions for reading single words. VBM showed that these regions were not significantly atrophied in SD. In control subjects, a region in the left intraparietal sulcus was activated for reading pseudowords and low-frequency regular words but not exception words, suggesting a role for this area in subword mapping from orthographic to phonological representations. In SD patients only, this inferior parietal region, which was not atrophied, was also activated by reading low-frequency exception words, especially on trials where over-regularization errors occurred. These results suggest that the left intraparietal sulcus is involved in subword reading processes that are differentially recruited in SD when word-specific information is lost. This loss is likely related to degeneration of the anterior temporal lobe, which was severely atrophied in SD. Consistent with this, left mid-fusiform and superior temporal regions that showed reading-related activations in controls were not activated in SD. Taken together, these results suggest that the left inferior parietal region subserves subword orthographic-to-phonological processes that are recruited for exception word reading when retrieval of exceptional, item-specific word forms is impaired by degeneration of the anterior temporal lobe.
Keyword: Original Articles
URL: https://doi.org/10.1093/brain/awn300
http://brain.oxfordjournals.org/cgi/content/short/132/1/71
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14
The neural basis of surface dyslexia in semantic dementia
Wilson, Stephen M.; Brambati, Simona M.; Henry, Roland G.. - : Oxford University Press, 2009
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15
The neural basis of surface dyslexia in semantic dementia
Wilson, Stephen M.; Brambati, Simona M.; Henry, Roland G.. - : Oxford University Press, 2008
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16
The anatomy of category-specific object naming in neurodegenerative diseases
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 18 (2006) 10, 1644-1653
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