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1
Speech production differences in English and Italian speakers with nonfluent variant PPA
In: Neurology (2020)
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2
Moving Toward Non-transcription Based Discourse Analysis in Stable and Progressive Aphasia
In: Speech Pathology and Audiology Faculty Research and Publications (2019)
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3
Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates
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4
Neurocognitive basis of repetition deficits in primary progressive aphasia
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5
Verbal Semantics and the Left Dorsolateral Anterior Temporal Lobe: A Longitudinal Case of Bilateral Temporal Degeneration
In: Aphasiology (2019)
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6
Semantic and lexical features of words dissimilarly affected by non-fluent, logopenic, and semantic primary progressive aphasia
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7
Neurocognitive Basis of Repetition Deficits in Primary Progressive Aphasia
In: Communication Sciences and Disorders Faculty Publications (2019)
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8
Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy
Abstract: IMPORTANCE: Increased prevalence of language-based learning disabilities (LDs) has been previously reported in patients with primary progressive aphasia (PPA). This study hypothesized that patients with focal neurodegenerative syndromes outside the language network, such as posterior cortical atrophy (PCA), would have a higher rate of nonlanguage LDs, congruent with their mainly visuospatial presentation. OBJECTIVE: To investigate the prevalence and type of LD (language and/or mathematical and visuospatial) in a large cohort of patients with PCA compared with patients with logopenic variant PPA (lvPPA) and amnestic Alzheimer disease (AD). DESIGN, SETTING, AND PARTICIPANTS: This case-control study reviewed 279 medical records from a university-based clinic and research center for patients with neurodegenerative diseases for LD history, including patients with PCA (n = 95), patients with lvPPA (n = 84), and a matched cohort with amnestic AD (n = 100). No records were excluded. The study compared cognitive and neuroimaging features of patients with PCA with and without LDs. A review of the records of patients presenting from March 1, 1999, to August 31, 2014, revealed 95 PCA cases and 84 lvPPA cases. Then 100 patients with amnestic AD from this same period were chosen for comparison, matching against the groups for age, sex, and disease severity. Data analysis was performed from September 8, 2013, to November 6, 2017. MAIN OUTCOMES AND MEASURES: Prevalence of total LD history and prevalence of language and mathematical or visuospatial LD history across all cohorts. RESULTS: A total of 179 atypical AD cases (95 with PCA and 84 with lvPPA) and 100 disease control cases (amnestic AD) were included in the study. The groups were not statistically different for mean (SD) age at first visit (PCA, 61.9 [7.0] years; lvPPA, 65.1 [8.7] years; amnestic AD, 64.0 [12.6] years; P = .08), mean (SD) age at first symptom (PCA, 57.5 [7.0] years; lvPPA, 61.1 [9.0] years; amnestic AD, 59.6 [13.7] years; P = .06), or sex (PCA, 66.3% female; lvPPA, 56.0% female; amnestic AD, 57.0% female; P = .30) but differed on non–right-hand preference (PCA, 18.3%; lvPPA, 20.2%; amnestic AD, 7.7%; P = .04), race/ethnicity (PCA, 88.3% white; lvPPA, 99.0% white; amnestic AD, 80.0% white; P < .001), and mean (SD) educational level (PCA, 15.7 [3.2] years; lvPPA, 16.2 [3.3] years; amnestic AD, 14.8 [3.5] years; P = .02). A total of 18 of the 95 patients with PCA (18.9%) reported a history of LD, which is greater than the 3 of 100 patients (3.0%) in the amnestic AD cohort (P < .001) and the 10.0% expected rate in the general population (P = .007). In the PCA cohort, 13 of 95 patients (13.7%) had a nonlanguage mathematical and/or visuospatial LD; this rate was greater than that in the amnestic AD (1 of 100 [1.0%]; P < .001) and lvPPA (2 of 84 [2.4%]; P = .006) cohorts and greater than the 6.0% expected general population rate of mathematical LD (P = .003). Compared with the patients with PCA without LDs, the group with LDs had greater preservation of global cognition and a more right-lateralized pattern of atrophy. CONCLUSIONS AND RELEVANCE: Nonlanguage mathematical and visuospatial LDs were associated with focal, visuospatial predominant neurodegenerative clinical syndromes. This finding supports the hypothesis that neurodevelopmental differences in specific brain networks are associated with phenotypic manifestation of later-life neurodegenerative disease.
Keyword: Original Investigation
URL: http://www.ncbi.nlm.nih.gov/pubmed/29630699
https://doi.org/10.1001/jamaneurol.2018.0395
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027634/
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9
Visuospatial Functioning In The Primary Progressive Aphasias
Watson, Christa L.; Possin, Katherine; Allen, I. Elaine. - : Cambridge Univ Press, 2018
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10
Rates Of Amyloid Imaging Positivity In Patients With Primary Progressive Aphasia
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11
Visuospatial Functioning in the Primary Progressive Aphasias
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12
Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia
Mandelli, Maria Luisa; Vilaplana, Eduard; Brown, Jesse A.. - : Oxford University Press, 2016
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13
Cross-sectional and longitudinal features of non-fluent/agrammatic primary progressive aphasia with underlying corticobasal degeneration or progressive supranuclear palsy pathology
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14
Speech entrainment enables patients with Broca's aphasia to produce fluent speech
Fridriksson, Julius; Hubbard, H. Isabel; Hudspeth, Sarah Grace. - : Oxford University Press, 2012
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