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1
Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
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2
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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3
Improving the diagnostic accuracy of primary progressive aphasia using cognitive tests
Foxe, David Gordon. - : The University of Sydney, 2022. : Faculty of Science, School of Psychology, 2022
Abstract: Primary progressive aphasias (PPA) are rare younger-onset dementias that primarily affect speech and language functions. Three subtypes of PPA have been identified and are classified based on the presence or absence of core language, imaging, and clinical findings: logopenic (lv-PPA), non-fluent (nfv-PPA) and semantic variant (sv-PPA). Differentiating these variants is important for treatment and planning; however, assessment of the nfv-PPA and lv-PPA variants’ speech and language is often difficult for clinicians with limited expertise. As such, simple language, cognitive, and behavioural tests are needed to aid diagnosis. This thesis comprises five studies that investigates this issue. Chapter 3 showed that, relative to the other PPA variants, lv-PPA is particularly impaired on a simple measure of visuospatial short-term memory, and that this impairment relates to the grey matter intensity decrease of the parietal lobe and surrounding regions. Chapter 4 expanded on these findings using a novel, computerised visuospatial working memory test. Using the cognitive subdomain scores of a cognitive screening tool (ACE-III), Chapter 5 found that the cognitive profiles of the PPA variants were distinct at baseline visit and over time. Crucially, cognitive decline in lv-PPA was more widespread and rapid than in nfv-PPA and sv-PPA. Chapter 6 demonstrated that PPA profiling is enhanced when evaluating the individual items of the ACE-III, and an interactive online ACE-III PPA diagnostic calculator was built for clinicians. Finally, Chapter 7 established that the mood, behaviour, and everyday skills profiles of the PPA variants are distinct at initial presentation and over the disease course. The work within this thesis demonstrates that the evolving cognitive and behavioural profiles of the PPA variants are distinct and extend beyond the primary disorder of language. Accordingly, assessing these skills in clinical practice can improve the diagnostic accuracy of the PPA variants.
Keyword: Alzheimer's disease; frontotemporal dementia; neuropsy; primary progressive aphasia
URL: https://hdl.handle.net/2123/27582
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4
A Meta-Analysis of Semantic Memory in Mild Cognitive Impairment
In: ISSN: 1040-7308 ; EISSN: 1573-6660 ; Neuropsychology Review ; https://hal.archives-ouvertes.fr/hal-03015335 ; Neuropsychology Review, Springer Verlag, 2021, ⟨10.1007/s11065-020-09453-5⟩ (2021)
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5
Cognitive Impairment in Late-Life Depression: A Comparative Study of Healthy Older People, Late-Life Depression, and Mild Alzheimer's Disease Using Multivariate Base Rates of Low Scores
In: EISSN: 1664-1078 ; Frontiers in Psychology ; https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630024 ; Frontiers in Psychology, Frontiers, 2021, 12, pp.724731. ⟨10.3389/fpsyg.2021.724731⟩ (2021)
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6
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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7
Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults.
Rankin, Katherine P; Toller, Gianina; Gavron, Lauren. - : eScholarship, University of California, 2021
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8
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021
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9
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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10
Asian Americans and Pacific Islanders' perspectives on participating in the CARE recruitment research registry for Alzheimer's disease and related dementias, aging, and caregiving research.
In: Alzheimer's & dementia (New York, N. Y.), vol 7, iss 1 (2021)
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11
APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 17, iss 3 (2021)
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12
The New Face of Caregiving: Multidimensional Factors of Caregiver Burden Among Young Adult Caregivers
Demko, Courtney Marie. - : eScholarship, University of California, 2021
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13
Data for: Correlates of Anomia in non-semantic Variants of Primary Progressive Aphasia Converge over Time ...
Leyton, Cristian. - : Mendeley, 2021
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14
Data for: Correlates of Anomia in non-semantic Variants of Primary Progressive Aphasia Converge over Time ...
Leyton, Cristian. - : Mendeley, 2021
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15
Student Project: Semantic Priming and Alzheimer's Disease (Oliver Rimkus)- Template ...
Nowak, Alexander. - : Open Science Framework, 2021
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16
Aprendre idiomes de gran crea connexions neuronals beneficioses
Bueno i Torrens, David, 1965-. - : Edició de Premsa Periòdica Ara, 2021
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17
Deterioros lingüísticos asociados a un caso clínico de demencia tipo alzhéimer ; Language impairments associated with a clinical case of Alzheimer’s dementia
Jiménez Ruiz, Juan Luis; Palenzuela Sánchez, Ángeles. - : Universidad Nacional Autónoma de México, 2021
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18
Network Effects Of Reduced Audibility (NEORA) and its Significance for Cognitive Decline
Alcock, C. - : University of Exeter, 2021. : College of Engineering, Mathematics, and Physical Sciences, 2021
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19
Edinburgh Cognitive and Behavioural ALS Screen (ECAS) in the assessment of early onset dementia
De Icaza Valenzuela, Mónica Mariana. - : The University of Edinburgh, 2021
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20
Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia
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