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Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study. ...
Hope, Thomas MH; Nardo, Davide; Holland, Rachel. - : Apollo - University of Cambridge Repository, 2021
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NUVA: A Naming Utterance Verifier for Aphasia Treatment ...
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Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study
In: Sci Rep (2021)
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Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study.
Hope, Thomas MH; Nardo, Davide; Holland, Rachel; Ondobaka, Sasha; Akkad, Haya; Price, Cathy J; Leff, Alexander P; Crinion, Jenny. - : Springer Science and Business Media LLC, 2021. : Sci Rep, 2021
Abstract: Stroke is a leading cause of disability, and language impairments (aphasia) after stroke are both common and particularly feared. Most stroke survivors with aphasia exhibit anomia (difficulties with naming common objects), but while many therapeutic interventions for anomia have been proposed, treatment effects are typically much larger in some patients than others. Here, we asked whether that variation might be more systematic, and even predictable, than previously thought. 18 patients, each at least 6 months after left hemisphere stroke, engaged in a computerised treatment for their anomia over a 6-week period. Using only: (a) the patients' initial accuracy when naming (to-be) trained items; (b) the hours of therapy that they devoted to the therapy; and (c) whole-brain lesion location data, derived from structural MRI; we developed Partial Least Squares regression models to predict the patients' improvements on treated items, and tested them in cross-validation. Somewhat surprisingly, the best model included only lesion location data and the hours of therapy undertaken. In cross-validation, this model significantly out-performed the null model, in which the prediction for each patient was simply the mean treatment effect of the group. This model also made promisingly accurate predictions in absolute terms: the correlation between empirical and predicted treatment response was 0.62 (95% CI 0.27, 0.95). Our results indicate that individuals' variation in response to anomia treatment are, at least somewhat, systematic and predictable, from the interaction between where and how much lesion damage they have suffered, and the time they devoted to the therapy.
URL: https://www.repository.cam.ac.uk/handle/1810/328311
https://doi.org/10.17863/CAM.75762
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Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study
Hope, Thomas M. H.; Nardo, Davide; Holland, Rachel. - : Nature Publishing Group UK, 2021. : Scientific Reports, 2021
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6
NUVA: A Naming Utterance Verifier for Aphasia Treatment
In: Comput Speech Lang (2021)
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7
Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging ...
Fleming, Victoria; Brownsett, Sonia; Krason, Anna. - : Apollo - University of Cambridge Repository, 2020
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8
Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging. ...
Fleming, Victoria; Brownsett, Sonia; Krason, Anna. - : Apollo - University of Cambridge Repository, 2020
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9
Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging.
Fleming, Victoria; Brownsett, Sonia; Krason, Anna. - : BMJ, 2020. : J Neurol Neurosurg Psychiatry, 2020
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10
Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging
Fleming, Victoria; Brownsett, Sonia; Krason, Anna. - : BMJ Publishing Group, 2020
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11
Right hemisphere structural adaptation and changing language skills years after left hemisphere stroke
Hope, Thomas M. H.; Leff, Alex P.; Prejawa, Susan. - : Oxford University Press, 2017
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12
Comparing language outcomes in monolingual and bilingual stroke patients
Hope, Thomas M. H.; Parker Jones, ‘Ōiwi; Grogan, Alice. - : Oxford University Press, 2015
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13
Patterns of Dysgraphia in Primary Progressive Aphasia Compared to Post-Stroke Aphasia
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14
Neuroimaging in aphasia treatment research: quantifying brain lesions after stroke
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15
Neuroimaging in aphasia treatment research: Consensus and practical guidelines for data analysis
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16
Can tDCS enhance treatment of aphasia after stroke?
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 26 (2012) 9, 1169-1191
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OLC Linguistik
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17
Shocking speech
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 26 (2012) 9, 1077-1081
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OLC Linguistik
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18
Brain stimulation and language
Crinion, Jenny (Hrsg.). - S.l. : Psychology Press, Taylor & Francis Group, 2012
UB Frankfurt Linguistik
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19
The Effect of Aging on the Neural Correlates of Phonological Word Retrieval
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20
Neuroimaging in aphasia treatment research: Consensus and practical guidelines for data analysis
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