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1
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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2
Neural substrates of verbal repetition deficits in primary progressive aphasia.
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3
Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
In: MDPI (2021)
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4
Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
In: Multidisciplinary Digital Publishing Institute (2021)
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5
A category-selective semantic memory deficit for animate objects in semantic variant primary progressive aphasia
In: Brain Commun (2021)
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6
Neural substrates of verbal repetition deficits in primary progressive aphasia
In: Brain Commun (2021)
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7
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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8
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
Abstract: IntroductionFrontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed.MethodsIn March 2018, the Association for Frontotemporal Degeneration convened the Frontotemporal Degeneration Study Group meeting in Washington, DC, to discuss advances in the clinical science of FTLD.ResultsChallenges exist for conducting clinical trials in FTLD. Two of the greatest challenges are (1) the heterogeneity of FTLD syndromes leading to difficulties in efficiently measuring treatment effects and (2) the rarity of FTLD disorders leading to recruitment challenges.DiscussionNew personalized endpoints that are clinically meaningful to individuals and their families should be developed. Personalized approaches to analyzing MRI data, development of new fluid biomarkers and wearable technologies will help to improve the power to detect treatment effects in FTLD clinical trials and enable new, clinical trial designs, possibly leveraged from the experience of oncology trials. A computational visualization and analysis platform that can support novel analyses of combined clinical, genetic, imaging, biomarker data with other novel modalities will be critical to the success of these endeavors.
Keyword: Acquired Cognitive Impairment; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); ARTFL; Atrophy; Biomarker; Biomarkers; Brain Disorders; C9orf72; Clinical Research; Clinical Sciences; Clinical trial; Clinical Trials and Supportive Activities; Clinical Trials as Topic; Congresses as Topic; Dementia; Frontotemporal dementia; Frontotemporal Dementia (FTD); Frontotemporal Lobar Degeneration; FTD; FTLD; Genetics; Geriatrics; GRN; Humans; LEFFTDS; Magnetic Resonance Imaging; MAPT; Neurodegenerative; Neurosciences; Primary progressive aphasia; Progressive supranuclear palsy; Rare Diseases
URL: https://escholarship.org/uc/item/13t6f67b
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9
Atrophy in Distinct Corticolimbic Networks Subserving Socioaffective Behavior in Semantic-Variant Primary Progressive Aphasia
In: Dement Geriatr Cogn Disord (2020)
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10
Word retrieval across the biomarker-confirmed Alzheimer’s disease syndromic spectrum
In: Neuropsychologia (2020)
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11
Altered functional connectivity of cortical networks in semantic variant Primary Progressive Aphasia
In: Neuroimage Clin (2020)
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12
Longitudinal structural and metabolic changes in frontotemporal dementia
In: Neurology (2020)
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13
Visual cognition in non-amnestic Alzheimer's disease: Relations to tau, amyloid, and cortical atrophy
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14
Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia
Cordella, Claire; Quimby, Megan; Touroutoglou, Alexandra. - : Lippincott Williams & Wilkins, 2019
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15
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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16
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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17
Flortaucipir tau PET imaging in semantic variant primary progressive aphasia
Makaretz, Sara J; Quimby, Megan; Collins, Jessica. - : BMJ Publishing Group, 2018
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18
Executive Dysfunction Contributes to Verbal Encoding and Retrieval Deficits in Posterior Cortical Atrophy
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19
Functional connectivity in category-selective brain networks after encoding predicts subsequent memory: Category selective connectivity predicts memory
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20
Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia
Collins, Jessica A.; Montal, Victor; Hochberg, Daisy. - : Oxford University Press, 2017
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