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1
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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2
Neural substrates of verbal repetition deficits in primary progressive aphasia.
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3
Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
In: MDPI (2021)
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4
Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
In: Multidisciplinary Digital Publishing Institute (2021)
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5
A category-selective semantic memory deficit for animate objects in semantic variant primary progressive aphasia
In: Brain Commun (2021)
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6
Neural substrates of verbal repetition deficits in primary progressive aphasia
In: Brain Commun (2021)
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7
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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8
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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9
Atrophy in Distinct Corticolimbic Networks Subserving Socioaffective Behavior in Semantic-Variant Primary Progressive Aphasia
In: Dement Geriatr Cogn Disord (2020)
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10
Word retrieval across the biomarker-confirmed Alzheimer’s disease syndromic spectrum
In: Neuropsychologia (2020)
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11
Altered functional connectivity of cortical networks in semantic variant Primary Progressive Aphasia
In: Neuroimage Clin (2020)
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12
Longitudinal structural and metabolic changes in frontotemporal dementia
In: Neurology (2020)
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13
Visual cognition in non-amnestic Alzheimer's disease: Relations to tau, amyloid, and cortical atrophy
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14
Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia
Cordella, Claire; Quimby, Megan; Touroutoglou, Alexandra. - : Lippincott Williams & Wilkins, 2019
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15
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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16
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
Abstract: ObjectiveThe prognostic value of cerebrospinal fluid neurofilament light chain, total tau, phosphorylated tau181, and amyloid beta1-42 was examined in frontotemporal dementia subtypes.MethodsWe compared baseline biomarkers between 49 controls, 40 patients with behavioral variant frontotemporal dementia, 24 with semantic variant primary progressive aphasia, and 26 with nonfluent variant primary progressive aphasia. Linear mixed effect models were used to assess the value of baseline biomarkers in predicting clinical and radiographic change in patient cohorts over multiple yearly follow up visits.ResultsNeurofilament light chain concentrations were lowest in controls. Elevated baseline neurofilament light chain predicted faster worsening in clinical severity, frontotemporal volume and frontotemporal fractional anisotropy in patients with behavioral variant frontotemporal dementia and nonfluent variant primary progressive aphasia. High total tau similarly predicted faster progression in nonfluent variant primary progressive aphasia. In behavioral variant frontotemporal dementia, higher phosphorylated tau181 predicted faster clinical progression whereas lower amyloid beta1-42 predicted faster volumetric and fractional anisotropy reduction. Neurofilament light chain and phosphorylated tau181 were of greater predictive value in patients with tau pathology as compared to TDP-43 pathology. Baseline neurofilament light chain correlated with baseline clinical severity and frontotemporal volume in behavioral variant frontotemporal dementia. Baseline total tau correlated with baseline clinical severity in semantic variant primary progressive aphasia.InterpretationHigh cerebrospinal fluid neurofilament light chain predicts more aggressive disease in behavioral variant frontotemporal dementia and nonfluent variant primary progressive aphasia. Total tau, phosphorylated tau181, and amyloid beta1-42 also predict some measures of disease aggressiveness in frontotemporal dementia.
Keyword: Clinical Sciences; Neurosciences
URL: https://escholarship.org/uc/item/74t3v9p8
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17
Flortaucipir tau PET imaging in semantic variant primary progressive aphasia
Makaretz, Sara J; Quimby, Megan; Collins, Jessica. - : BMJ Publishing Group, 2018
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18
Executive Dysfunction Contributes to Verbal Encoding and Retrieval Deficits in Posterior Cortical Atrophy
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19
Functional connectivity in category-selective brain networks after encoding predicts subsequent memory: Category selective connectivity predicts memory
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20
Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia
Collins, Jessica A.; Montal, Victor; Hochberg, Daisy. - : Oxford University Press, 2017
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