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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 Hits 1 – 20 of 31 1 Cortical microstructure in primary progressive aphasia: a multicenter study. Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi; Mandelli, Maria Luisa; Falgàs, Neus; Welch, Ariane E; Pegueroles, Jordi; Santos-Santos, Miguel; Bejanin, Alexandre; Alcolea, Daniel; Dols-Icardo, Oriol; Belbin, Olivia; Sánchez-Saudinós, Mª Belén; Bargalló, Nuria; González-Ortiz, Sofía; Lladó, Albert; Blesa, Rafael; Dickerson, Bradford C; Rosen, Howard J; Miller, Bruce L; Lleó, Alberto; Gorno-Tempini, Maria Luisa; Sánchez-Valle, Raquel; Fortea, Juan In: Alzheimer's research & therapy, vol 14, iss 1 (2022) Abstract: BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).MethodsIn this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.ResultsThe comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.ConclusionsCortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA. Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Biomedical Imaging; Brain Disorders; Case-Control Studies; Clinical Research; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Frontotemporal Dementia (FTD); Frontotemporal lobar degeneration; Humans; Magnetic resonance; Magnetic Resonance Imaging; Medical and Health Sciences; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Primary progressive aphasia; Rare Diseases URL: https://escholarship.org/uc/item/4td346vg BASE Hide details 2 Neural substrates of verbal repetition deficits in primary progressive aphasia. Dickerson, Bradford C.; Ezzo, Rania; Cordella, Claire. - 2021 BASE Show details 3 Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia Gallée, Jeanne; Cordella, Claire; Fedorenko, Evelina G... In: MDPI (2021) BASE Show details 4 Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia Gallée, Jeanne; Cordella, Claire; Fedorenko, Evelina... In: Multidisciplinary Digital Publishing Institute (2021) BASE Show details 5 A category-selective semantic memory deficit for animate objects in semantic variant primary progressive aphasia Henderson, Shalom K; Dev, Sheena I; Ezzo, Rania... In: Brain Commun (2021) BASE Show details 6 Neural substrates of verbal repetition deficits in primary progressive aphasia Miller, Hilary E; Cordella, Claire; Collins, Jessica A... In: Brain Commun (2021) BASE Show details 7 New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Boxer, Adam L; Gold, Michael; Feldman, Howard... In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020) BASE Show details 8 New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Boxer, Adam L; Gold, Michael; Feldman, Howard... In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020) BASE Show details 9 Atrophy in Distinct Corticolimbic Networks Subserving Socioaffective Behavior in Semantic-Variant Primary Progressive Aphasia Eldaief, Mark C.; Perez, David L.; Quimby, Megan... In: Dement Geriatr Cogn Disord (2020) BASE Show details 10 Word retrieval across the biomarker-confirmed Alzheimer’s disease syndromic spectrum Putcha, Deepti; Dickerson, Bradford C.; Brickhouse, Michael... In: Neuropsychologia (2020) BASE Show details 11 Altered functional connectivity of cortical networks in semantic variant Primary Progressive Aphasia Popal, Haroon; Quimby, Megan; Hochberg, Daisy... In: Neuroimage Clin (2020) BASE Show details 12 Longitudinal structural and metabolic changes in frontotemporal dementia Bejanin, Alexandre; Tammewar, Gautam; Marx, Gabe... In: Neurology (2020) BASE Show details 13 Visual cognition in non-amnestic Alzheimer's disease: Relations to tau, amyloid, and cortical atrophy Putcha, Deepti; Brickhouse, Michael; Touroutoglou, Alexandra. - : Elsevier, 2019 BASE Show details 14 Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia Cordella, Claire; Quimby, Megan; Touroutoglou, Alexandra. - : Lippincott Williams & Wilkins, 2019 BASE Show details 15 Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ljubenkov, Peter A; Staffaroni, Adam M; Rojas, Julio C... In: Annals of clinical and translational neurology, vol 5, iss 10 (2018) BASE Show details 16 Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ljubenkov, Peter A; Staffaroni, Adam M; Rojas, Julio C... In: Annals of clinical and translational neurology, vol 5, iss 10 (2018) BASE Show details 17 Flortaucipir tau PET imaging in semantic variant primary progressive aphasia Makaretz, Sara J; Quimby, Megan; Collins, Jessica. - : BMJ Publishing Group, 2018 BASE Show details 18 Executive Dysfunction Contributes to Verbal Encoding and Retrieval Deficits in Posterior Cortical Atrophy Putcha, Deepti; McGinnis, Scott M.; Brickhouse, Michael. - 2018 BASE Show details 19 Functional connectivity in category-selective brain networks after encoding predicts subsequent memory: Category selective connectivity predicts memory Collins, Jessica A.; Dickerson, Bradford C.. - 2018 BASE Show details 20 Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia Collins, Jessica A.; Montal, Victor; Hochberg, Daisy. - : Oxford University Press, 2017 BASE Show details Page: 1 2

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