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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 Hits 1 – 20 of 31 1 Cortical microstructure in primary progressive aphasia: a multicenter study. Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi... In: Alzheimer's research & therapy, vol 14, iss 1 (2022) BASE Show details 2 Neural substrates of verbal repetition deficits in primary progressive aphasia. Dickerson, Bradford C.; Ezzo, Rania; Cordella, Claire. - 2021 BASE Show details 3 Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia Gallée, Jeanne; Cordella, Claire; Fedorenko, Evelina G... In: MDPI (2021) BASE Show details 4 Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia Gallée, Jeanne; Cordella, Claire; Fedorenko, Evelina... In: Multidisciplinary Digital Publishing Institute (2021) BASE Show details 5 A category-selective semantic memory deficit for animate objects in semantic variant primary progressive aphasia Henderson, Shalom K; Dev, Sheena I; Ezzo, Rania; Quimby, Megan; Wong, Bonnie; Brickhouse, Michael; Hochberg, Daisy; Touroutoglou, Alexandra; Dickerson, Bradford C; Cordella, Claire; Collins, Jessica A In: Brain Commun (2021) Abstract: Data are mixed on whether patients with semantic variant primary progressive aphasia exhibit a category-selective semantic deficit for animate objects. Moreover, there is little consensus regarding the neural substrates of this category-selective semantic deficit, though prior literature has suggested that the perirhinal cortex and the lateral posterior fusiform gyrus may support semantic memory functions important for processing animate objects. In this study, we investigated whether patients with semantic variant primary progressive aphasia exhibited a category-selective semantic deficit for animate objects in a word-picture matching task, controlling for psycholinguistic features of the stimuli, including frequency, familiarity, typicality and age of acquisition. We investigated the neural bases of this category selectivity by examining its relationship with cortical atrophy in two primary regions of interest: bilateral perirhinal cortex and lateral posterior fusiform gyri. We analysed data from 20 patients with semantic variant primary progressive aphasia (mean age = 64 years, S.D. = 6.94). For each participant, we calculated an animacy index score to denote the magnitude of the category-selective semantic deficit for animate objects. Multivariate regression analysis revealed a main effect of animacy (β = 0.52, t = 4.03, P < 0.001) even after including all psycholinguistic variables in the model, such that animate objects were less likely to be identified correctly relative to inanimate objects. Inspection of each individual patient’s data indicated the presence of a disproportionate impairment in animate objects in most patients. A linear regression analysis revealed a relationship between the right perirhinal cortex thickness and animacy index scores (β = −0.57, t = −2.74, P = 0.015) such that patients who were more disproportionally impaired for animate relative to inanimate objects exhibited thinner right perirhinal cortex. A vertex-wise general linear model analysis restricted to the temporal lobes revealed additional associations between positive animacy index scores (i.e. a disproportionately poorer performance on animate objects) and cortical atrophy in the right perirhinal and entorhinal cortex, superior, middle, and inferior temporal gyri, and the anterior fusiform gyrus, as well as the left anterior fusiform gyrus. Taken together, our results indicate that a category-selective semantic deficit for animate objects is a characteristic feature of semantic variant primary progressive aphasia that is detectable in most individuals. Our imaging findings provide further support for the role of the right perirhinal cortex and other temporal lobe regions in the semantic processing of animate objects. Keyword: Original Article URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493104/ https://doi.org/10.1093/braincomms/fcab210 BASE Hide details 6 Neural substrates of verbal repetition deficits in primary progressive aphasia Miller, Hilary E; Cordella, Claire; Collins, Jessica A... In: Brain Commun (2021) BASE Show details 7 New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Boxer, Adam L; Gold, Michael; Feldman, Howard... In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020) BASE Show details 8 New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Boxer, Adam L; Gold, Michael; Feldman, Howard... In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020) BASE Show details 9 Atrophy in Distinct Corticolimbic Networks Subserving Socioaffective Behavior in Semantic-Variant Primary Progressive Aphasia Eldaief, Mark C.; Perez, David L.; Quimby, Megan... In: Dement Geriatr Cogn Disord (2020) BASE Show details 10 Word retrieval across the biomarker-confirmed Alzheimer’s disease syndromic spectrum Putcha, Deepti; Dickerson, Bradford C.; Brickhouse, Michael... In: Neuropsychologia (2020) BASE Show details 11 Altered functional connectivity of cortical networks in semantic variant Primary Progressive Aphasia Popal, Haroon; Quimby, Megan; Hochberg, Daisy... In: Neuroimage Clin (2020) BASE Show details 12 Longitudinal structural and metabolic changes in frontotemporal dementia Bejanin, Alexandre; Tammewar, Gautam; Marx, Gabe... In: Neurology (2020) BASE Show details 13 Visual cognition in non-amnestic Alzheimer's disease: Relations to tau, amyloid, and cortical atrophy Putcha, Deepti; Brickhouse, Michael; Touroutoglou, Alexandra. - : Elsevier, 2019 BASE Show details 14 Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia Cordella, Claire; Quimby, Megan; Touroutoglou, Alexandra. - : Lippincott Williams & Wilkins, 2019 BASE Show details 15 Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ljubenkov, Peter A; Staffaroni, Adam M; Rojas, Julio C... In: Annals of clinical and translational neurology, vol 5, iss 10 (2018) BASE Show details 16 Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ljubenkov, Peter A; Staffaroni, Adam M; Rojas, Julio C... In: Annals of clinical and translational neurology, vol 5, iss 10 (2018) BASE Show details 17 Flortaucipir tau PET imaging in semantic variant primary progressive aphasia Makaretz, Sara J; Quimby, Megan; Collins, Jessica. - : BMJ Publishing Group, 2018 BASE Show details 18 Executive Dysfunction Contributes to Verbal Encoding and Retrieval Deficits in Posterior Cortical Atrophy Putcha, Deepti; McGinnis, Scott M.; Brickhouse, Michael. - 2018 BASE Show details 19 Functional connectivity in category-selective brain networks after encoding predicts subsequent memory: Category selective connectivity predicts memory Collins, Jessica A.; Dickerson, Bradford C.. - 2018 BASE Show details 20 Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia Collins, Jessica A.; Montal, Victor; Hochberg, Daisy. - : Oxford University Press, 2017 BASE Show details Page: 1 2

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