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1
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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2
Neural substrates of verbal repetition deficits in primary progressive aphasia.
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3
Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
In: MDPI (2021)
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4
Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
In: Multidisciplinary Digital Publishing Institute (2021)
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5
A category-selective semantic memory deficit for animate objects in semantic variant primary progressive aphasia
In: Brain Commun (2021)
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6
Neural substrates of verbal repetition deficits in primary progressive aphasia
In: Brain Commun (2021)
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7
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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8
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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9
Atrophy in Distinct Corticolimbic Networks Subserving Socioaffective Behavior in Semantic-Variant Primary Progressive Aphasia
In: Dement Geriatr Cogn Disord (2020)
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10
Word retrieval across the biomarker-confirmed Alzheimer’s disease syndromic spectrum
In: Neuropsychologia (2020)
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11
Altered functional connectivity of cortical networks in semantic variant Primary Progressive Aphasia
In: Neuroimage Clin (2020)
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12
Longitudinal structural and metabolic changes in frontotemporal dementia
In: Neurology (2020)
Abstract: OBJECTIVE: To compare the sensitivity of structural MRI and (18)F-fludeoxyglucose PET ((18)FDG-PET) to detect longitudinal changes in frontotemporal dementia (FTD). METHODS: Thirty patients with behavioral variant FTD (bvFTD), 7 with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA), 16 with semantic variant primary progressive aphasia (svPPA), and 43 cognitively normal controls underwent 2–4 MRI and (18)FDG-PET scans (total scans/visit = 270) as part of the Frontotemporal Lobar Degeneration Neuroimaging Initiative study. Linear mixed-effects models were carried out voxel-wise and in regions of interest to identify areas showing decreased volume or metabolism over time in patients as compared to controls. RESULTS: At baseline, patients with bvFTD showed bilateral temporal, dorsolateral, and medial prefrontal atrophy/hypometabolism that extended with time into adjacent structures and parietal lobe. In nfvPPA, baseline atrophy/hypometabolism in supplementary motor cortex extended with time into left greater than right precentral, dorsolateral, and dorsomedial prefrontal cortex. In svPPA, baseline atrophy/hypometabolism encompassed the anterior temporal and medial prefrontal cortex and longitudinal changes were found in temporal, orbitofrontal, and lateral parietal cortex. Across syndromes, there was substantial overlap in the brain regions showing volume and metabolism loss. Even though the pattern of metabolic decline was more extensive, metabolic changes were also more variable and sample size estimates were similar or higher for (18)FDG-PET compared to MRI. CONCLUSION: Our findings demonstrated the sensitivity of (18)FDG-PET and structural MRI for tracking disease progression in FTD. Both modalities showed highly overlapping patterns of longitudinal change and comparable sample size estimates to detect longitudinal changes in future clinical trials.
Keyword: Article
URL: https://doi.org/10.1212/WNL.0000000000009760
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455324/
http://www.ncbi.nlm.nih.gov/pubmed/32591470
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13
Visual cognition in non-amnestic Alzheimer's disease: Relations to tau, amyloid, and cortical atrophy
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14
Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia
Cordella, Claire; Quimby, Megan; Touroutoglou, Alexandra. - : Lippincott Williams & Wilkins, 2019
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15
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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16
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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17
Flortaucipir tau PET imaging in semantic variant primary progressive aphasia
Makaretz, Sara J; Quimby, Megan; Collins, Jessica. - : BMJ Publishing Group, 2018
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18
Executive Dysfunction Contributes to Verbal Encoding and Retrieval Deficits in Posterior Cortical Atrophy
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19
Functional connectivity in category-selective brain networks after encoding predicts subsequent memory: Category selective connectivity predicts memory
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20
Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia
Collins, Jessica A.; Montal, Victor; Hochberg, Daisy. - : Oxford University Press, 2017
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