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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 6 of 6 1 Subthalamic nucleus stimulation effects on single and combined task performance in Parkinson’s disease patients: a PET study Atkinson-Clement, Cyril; Maillet, Audrey; Lebars, Didier; Lavenne, Franck; Redoute, Jerome; Krainik, Alexandre; Pollak, Pierre; Thobois, Stephane C; Pinto, Serge In: ISSN: 1931-7557 ; EISSN: 1931-7565 ; Brain imaging and behavior (Brain Imaging Behav) ; https://hal-amu.archives-ouvertes.fr/hal-01777362 ; Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, 2017, 11 (4), pp.1139 - 1153. ⟨10.1007/s11682-016-9588-4⟩ (2017) Abstract: International audience ; Subthalamic nucleus deep brain stimulation (STNDBS) represents one of the most efficacious treatments for Parkinson’s disease, along with L-dopa therapy. The objective of the present work was to identify the cerebral networks associated with hand movement and speech production tasks performed alone and simultaneously, as well as the effects of STN-DBS on these profiles. Clinical, behavioral, and neuroimaging (oxygen 15-labeled water and Positron Emission Tomography) investigations were used to study single and combined performances of unilateral hand movements and speech production in 11 unmedicated individuals with PD, both off and on STN-DBS. Specifically, a flexible factorial design with the tasks (hand movement, speech production, combined task) and the STN-DBS conditions (off, on) as main factors was chosen for brain activation statistical analysis, using a Family-Wise Error corrected p-value at the cluster level of at least 10 contiguous voxels. Increased activation of fronto-parietal and cingulate areas was observed under STN-DBS for hand movement in single and combined tasks, respectively, reflecting a partial restoration of cortico-subcortical connections. The lack of results for speech production for both off and on STN-DBS could illustrate its relatively poor response to the treatment. STN-DBS tended to restore the additive function capacity that can be achieved when performing the combined task. We confirmed with original neuroimaging data that speech is much less responsive to STN-DBS than any other motor function and we concluded that speech outcomes following STN-DBS can be different from those observed pre-operatively following L-dopa administration. Keyword: [SCCO]Cognitive science; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; [SHS.LANGUE]Humanities and Social Sciences/Linguistics; Deep brain stimulation; Hand movement; Neuroimaging; Parkinson’s disease; Speech; Subthalamic nucleus URL: https://doi.org/10.1007/s11682-016-9588-4 https://hal-amu.archives-ouvertes.fr/hal-01777362 BASE Hide details 2 Stimulation of the pedunculopontine nucleus area in Parkinson's disease: effects on speech and intelligibility Pinto, Serge; Ferraye, Murielle; Espesser, Robert... In: ISSN: 0006-8950 ; EISSN: 1460-2156 ; Brain - A Journal of Neurology ; https://hal.archives-ouvertes.fr/hal-01485955 ; Brain - A Journal of Neurology , Oxford University Press (OUP), 2014, 137, pp.2759-2772. ⟨10.1093/brain/awu209⟩ (2014) BASE Show details 3 Levodopa effects on hand and speech movements in patients with Parkinson's disease: a FMRI study. Maillet, Audrey; Krainik, Alexandre; Debû, Bettina... In: ISSN: 1932-6203 ; EISSN: 1932-6203 ; PLoS ONE ; https://www.hal.inserm.fr/inserm-00874568 ; PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e46541. ⟨10.1371/journal.pone.0046541⟩ (2012) BASE Show details 4 Levodopa effects on hand and speech movements in patients with Parkinson's disease: a FMRI study Maillet, Audrey; Krainik, Alexandre; Debû, Bettina... In: ISSN: 1932-6203 ; PLOS ONE, Vol. 7, No 10 (2012) P. e46541 (2012) BASE Show details 5 Levodopa Effects on Hand and Speech Movements in Patients with Parkinson’s Disease: A fMRI Study Maillet, Audrey; Krainik, Alexandre; Debû, Bettina. - : Public Library of Science, 2012 BASE Show details 6 Effects of pedunculopontine nucleus area stimulation on speech production in Parkinson's disease Pinto, Serge; Maillet, Audrey; Ghio, Alain... In: 14th International Congress of Parkinson's Disease and Movement Disorders ; https://hal.archives-ouvertes.fr/hal-01619463 ; 14th International Congress of Parkinson's Disease and Movement Disorders, 2010, Buenos-Aires, Argentina. 2010 (2010) BASE Show details

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