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Subthalamic nucleus stimulation effects on single and combined task performance in Parkinson’s disease patients: a PET study
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In: ISSN: 1931-7557 ; EISSN: 1931-7565 ; Brain imaging and behavior (Brain Imaging Behav) ; https://hal-amu.archives-ouvertes.fr/hal-01777362 ; Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, 2017, 11 (4), pp.1139 - 1153. ⟨10.1007/s11682-016-9588-4⟩ (2017)
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Stimulation of the pedunculopontine nucleus area in Parkinson's disease: effects on speech and intelligibility
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In: ISSN: 0006-8950 ; EISSN: 1460-2156 ; Brain - A Journal of Neurology ; https://hal.archives-ouvertes.fr/hal-01485955 ; Brain - A Journal of Neurology , Oxford University Press (OUP), 2014, 137, pp.2759-2772. ⟨10.1093/brain/awu209⟩ (2014)
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Levodopa effects on hand and speech movements in patients with Parkinson's disease: a FMRI study.
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In: ISSN: 1932-6203 ; EISSN: 1932-6203 ; PLoS ONE ; https://www.hal.inserm.fr/inserm-00874568 ; PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e46541. ⟨10.1371/journal.pone.0046541⟩ (2012)
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Levodopa effects on hand and speech movements in patients with Parkinson's disease: a FMRI study
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In: ISSN: 1932-6203 ; PLOS ONE, Vol. 7, No 10 (2012) P. e46541 (2012)
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Levodopa Effects on Hand and Speech Movements in Patients with Parkinson’s Disease: A fMRI Study
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Abstract:
Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson’s disease (PD) differ greatly, leading to therapeutic challenges for managing the disabilities in this patient’s population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both off and on levodopa (L-dopa). Unilateral hand movements in the off medication state elicited brain activations in motor regions (primary motor cortex, supplementary motor area, premotor cortex, cerebellum), as well as additional areas (anterior cingulate, putamen, associative parietal areas); following L-dopa administration, the brain activation profile was globally reduced, highlighting activations in the parietal and posterior cingulate cortices. For the speech production task, brain activation patterns were similar with and without medication, including the orofacial primary motor cortex (M1), the primary somatosensory cortex and the cerebellar hemispheres bilaterally, as well as the left- premotor, anterior cingulate and supramarginal cortices. For the combined task off L-dopa, the cerebral activation profile was restricted to the right cerebellum (hand movement), reflecting the difficulty in performing two movements simultaneously in PD. Under L-dopa, the brain activation profile of the combined task involved a larger pattern, including additional fronto-parietal activations, without reaching the sum of the areas activated during the simple hand and speech tasks separately. Our results question both the role of the basal ganglia system in speech production and the modulation of task-dependent cerebral networks by dopaminergic treatment.
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Keyword:
Research Article
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URL: https://doi.org/10.1371/journal.pone.0046541
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467207
http://www.ncbi.nlm.nih.gov/pubmed/23056337
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Effects of pedunculopontine nucleus area stimulation on speech production in Parkinson's disease
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In: 14th International Congress of Parkinson's Disease and Movement Disorders ; https://hal.archives-ouvertes.fr/hal-01619463 ; 14th International Congress of Parkinson's Disease and Movement Disorders, 2010, Buenos-Aires, Argentina. 2010 (2010)
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