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1
Cortical microstructure in primary progressive aphasia: a multicenter study.
In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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2
Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia
In: Front Aging Neurosci (2021)
Abstract: Oculomotor behavior can provide insight into the integrity of widespread cortical networks, which may contribute to the differential diagnosis between Alzheimer's disease and frontotemporal dementia. Three groups of patients with Alzheimer's disease, behavioral variant of frontotemporal dementia (bvFTD) and semantic variant of primary progressive aphasia (svPPA) and a sample of cognitively unimpaired elders underwent an eye-tracking evaluation. All participants in the discovery sample, including controls, had a biomarker-supported diagnosis. Oculomotor correlates of neuropsychology and brain metabolism evaluated with 18F-FDG PET were explored. Machine-learning classification algorithms were trained for the differentiation between Alzheimer's disease, bvFTD and controls. A total of 93 subjects (33 Alzheimer's disease, 24 bvFTD, seven svPPA, and 29 controls) were included in the study. Alzheimer's disease was the most impaired group in all tests and displayed specific abnormalities in some visually-guided saccade parameters, as pursuit error and horizontal prosaccade latency, which are theoretically closely linked to posterior brain regions. BvFTD patients showed deficits especially in the most cognitively demanding tasks, the antisaccade and memory saccade tests, which require a fine control from frontal lobe regions. SvPPA patients performed similarly to controls in most parameters except for a lower number of correct memory saccades. Pursuit error was significantly correlated with cognitive measures of constructional praxis and executive function and metabolism in right posterior middle temporal gyrus. The classification algorithms yielded an area under the curve of 97.5% for the differentiation of Alzheimer's disease vs. controls, 96.7% for bvFTD vs. controls, and 92.5% for Alzheimer's disease vs. bvFTD. In conclusion, patients with Alzheimer's disease, bvFTD and svPPA exhibit differentiating oculomotor patterns which reflect the characteristic neuroanatomical distribution of pathology of each disease, and therefore its assessment can be useful in their diagnostic work-up. Machine learning approaches can facilitate the applicability of eye-tracking in clinical practice.
Keyword: Neuroscience
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891179/
https://doi.org/10.3389/fnagi.2020.603790
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3
Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia
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4
Maurici Serrahima i l'assaig
In: Estudis Romànics; 41 original; 457-461 ; 2013-9500 ; 0211-8572 (2019)
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5
Epistolari Juan Arbó - Joan Sales (1966-1982)
In: Llengua i literatura; 29 : 2019; p. 167-171 ; 0213-6554 (2019)
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6
Guardiola, Carles-Jordi: Carles Riba. Retrat de grup. Protagonistes de la cultura catalana del segle XX, València: Tresi Quatre, 2017.
In: Llengua i literatura; 29 : 2019; p. 230-233 ; 0213-6554 (2019)
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7
Miralles, Carles (2013): Sobre Espriu. Barcelona: Publicacions i Edicions de la Universitat de Barcelona, 411 p.
In: Estudis Romànics; Vol. , Núm. (2017): 39; p. 531-533 (2017)
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8
Acte d'homenatge a Carles Miralles
In: Estudis Romànics; Vol. , Núm. (2015): 37; p. 662-664 (2015)
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9
Acte d'homenatge a Carles Miralles
In: Estudis Romànics; 37; p. 662-664 (2015)
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10
Actes del III Simposi Carles Riba : Barcelona, 30 de novembre i I 1 2 de desembre de 2009
Miralles, Carlos (Herausgeber); Malé i Pegueroles, Jordi (Herausgeber); Pardell, Jordi Pujol (Herausgeber). - Barcelona : Institut d'Estudis Catalans, 2012
UB Frankfurt Linguistik
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11
El Jove poeta que no sabia què és amor. Safo, Leopardi i Baudelaire a les primeres Estances de Carles Riba
In: Llengua i literatura; Vol. , Núm. (2006): 17: 2006; p. 52-102 (2006)
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