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1
Speech production differences in English and Italian speakers with nonfluent variant PPA
In: Neurology (2020)
Abstract: OBJECTIVE: To understand whether the clinical phenotype of nonfluent/agrammatic primary progressive aphasia (nfvPPA) could present differences depending on the patient’s native language. METHODS: In this cross-sectional study, we analyzed connected speech samples in monolingual English (nfvPPA-E) and Italian speakers (nfvPPA-I) who were diagnosed with nfvPPA and matched for age, sex, and Mini-Mental State Examination scores. Patients also received a comprehensive neuropsychological battery. All patients and 2 groups of age-matched healthy controls underwent an MRI scan with 3D T1-weighted sequences. Connected speech measures and the other cognitive features were compared between patient groups. MRI variables, in terms of gray matter volume, were compared between each patient group and the corresponding controls. RESULTS: Compared to nfvPPA-E, nfvPPA-I had fewer years of education and shorter reported disease duration. The 2 groups showed similar regional atrophy compatible with clinical diagnosis. Patients did not differ in nonlanguage domains, comprising executive scores. Connected speech sample analysis showed that nfvPPA-E had significantly more distortions than nfvPPA-I, while nfvPPA-I showed reduced scores in some measures of syntactic complexity. On language measures, Italian speakers performed more poorly on syntactic comprehension. CONCLUSIONS: nfvPPA-E showed greater motor speech impairment than nfvPPA-I despite higher level of education and comparable disease severity and atrophy changes. The data also suggest greater grammatical impairment in nfvPPA-I. This study illustrates the need to take into account the possible effect of the individual's spoken language on the phenotype and clinical presentation of primary progressive aphasia variants.
Keyword: Article
URL: https://doi.org/10.1212/WNL.0000000000008879
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238919/
http://www.ncbi.nlm.nih.gov/pubmed/31924679
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2
Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia
In: Cortex (2019)
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3
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia
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4
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia
In: ISSN: 1619-7070 ; European Journal of Nuclear Medicine and Molecular Imaging, Vol. 45, No 9 (2018) pp. 1526-1533 (2018)
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5
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia
Bouwman, Femke; Orini, Stefania; Gandolfo, Federica. - : Springer Berlin Heidelberg, 2018
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6
Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia
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7
Typical and atypical pathology in primary progressive aphasia variants
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8
A multimodal neuroimaging study of a case of crossed nonfluent/agrammatic primary progressive aphasia
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9
Disruption of structural connectivity along the dorsal and ventral language pathways in patients with nonfluent and semantic variant primary progressive aphasia: A DT MRI study and a literature review
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 127 (2013) 2, 157-166
OLC Linguistik
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10
White matter damage in primary progressive aphasias: a diffusion tensor tractography study
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11
White matter damage in primary progressive aphasias: a diffusion tensor tractography study
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12
White matter damage in primary progressive aphasias: a diffusion tensor tractography study
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13
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2010
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14
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2010
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15
Neural correlates of syntactic processing in the non-fluent variant of primary progressive aphasia
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16
Language networks in semantic dementia
Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella. - : Oxford University Press, 2009
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17
The neural basis of surface dyslexia in semantic dementia
Wilson, Stephen M.; Brambati, Simona M.; Henry, Roland G.. - : Oxford University Press, 2009
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18
The neural basis of surface dyslexia in semantic dementia
Wilson, Stephen M.; Brambati, Simona M.; Henry, Roland G.. - : Oxford University Press, 2009
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19
The neural basis of surface dyslexia in semantic dementia
Wilson, Stephen M.; Brambati, Simona M.; Henry, Roland G.. - : Oxford University Press, 2008
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