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Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia
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Common variation within the SETBP1 gene is associated with reading-related skills and patterns of functional neural activation
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In: Neuropsychologia (2018)
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The BDNF Val66Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children
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Language development in rural and urban Russian-speaking children with and without developmental language disorder
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Lexical Processing Deficits in Children with Developmental Language Disorder: An Event-Related Potentials Study
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Interpretation of Anaphoric Dependencies in Russian-speaking Children with and without Developmental Language Disorder
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Neurophysiological and Genetic Bases of Developmental Language Disorder
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In: Doctoral Dissertations (2014)
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Abstract:
Four electrophysiological studies (using event-related potentials, ERPs) and one genome-wide association (GWAS) study investigated the neurophysiological and genetic bases of Developmental Language Disorder (DLD) in a geographically isolated Russian-speaking population with an elevated prevalence of DLD. Experiments 1 and 2 found that while children with DLD showed intact preattentive phonological discrimination mismatch negativity (MMN) component, they showed reduced amplitudes of the auditory P2 and P3b components in an attentional oddball task. These amplitudes were related to measures of lexical development and development of complex syntax, underscoring the role of working memory and attentional limitations in DLD. Experiment 3 examined lexical processing (i.e., the N400 component) in children with DLD and their typically developing (TD) peers and established the presence of lexical processing deficits in DLD potentially mediated by their phonological deficits but largely unrelated to deficits in grammatical development. Experiment 4 investigated children’s neural responses to violations of subject-verb grammatical gender agreement in Russian. Children with DLD showed a left-lateralized P600 in response to the morphologically-taxing violations, absent in TD children; they also showed a reduced amplitude of the P200-like component in response to verbs in general, suggesting the presence of early phonological and/or morphological processing deficits. The molecular genetic GWAS study identified a novel candidate DLD gene, SETBP1, located on chromosome 18q21 and associated with measures of the development of complex syntax. The patterns of intercorrelations between behavioral measures of cognitive/language development and ERPs and intercorrelations among ERPs suggested that behavioral heterogeneity of DLD manifestations is accompanied by its neurocognitive heterogeneity. Coupled with the results from the GWAS study, these findings support viewing DLD as a complex common neurodevelopmental disorder that is multivariate, dimensional and etiologically heterogeneous even when overall heterogeneity is reduced at both environmental and genetic levels.
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Keyword:
developmental language disorder; event-related potentials; genetics; genome-wide association study; language; memory; neurophysiology; specific language impairment
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URL: https://opencommons.uconn.edu/dissertations/479 https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=6710&context=dissertations
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Attentional but not Pre-Attentive Neural Measures of Auditory Discrimination are Atypical in Children with Developmental Language Disorder
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Spelling Well Despite Developmental Language Disorder: What Makes it Possible?
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Effect of repetition proportion on language-driven anticipatory eye movements
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Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population.
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Attentional but not pre-attentive neural measures of auditory discrimination are atypical in children with developmental language disorder.
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Spelling well despite developmental language disorder: what makes it possible?
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Lexical processing deficits in children with developmental language disorder: An event-related potentials study.
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Gender and agreement processing in children with developmental language disorder.
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