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Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer Based on Functional Assessment and NIRS Analysis
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In: Journal of Clinical Medicine; Volume 11; Issue 9; Pages: 2363 (2022)
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Functional Connectivity Signatures Underlying Simultaneous Language Translation in Interpreters and Non-Interpreters of Mandarin and English: An fNIRS Study
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In: Brain Sciences; Volume 12; Issue 2; Pages: 273 (2022)
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Associated functional network development and language abilities in children ...
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Action video games enhance attentional control and phonological decoding in children with developmental dyslexia
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Gene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes
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Abstract:
Background: The etiology of frontotemporal dementia (FTD) is poorly understood. To identify genes with predicted expression levels associated with FTD, we integrated summary statistics with external reference gene expression data using a transcriptome-wide association study approach. Methods: FUSION software was used to leverage FTD summary statistics (all FTD: n = 2154 cases, n = 4308 controls; behavioral variant FTD: n = 1337 cases, n = 2754 controls; semantic dementia: n = 308 cases, n = 616 controls; progressive nonfluent aphasia: n = 269 cases, n = 538 controls; FTD with motor neuron disease: n = 200 cases, n = 400 controls) from the International FTD-Genomics Consortium with 53 expression quantitative loci tissue type panels (n = 12,205; 5 consortia). Significance was assessed using a 5% false discovery rate threshold. Results: We identified 73 significant gene–tissue associations for FTD, representing 44 unique genes in 34 tissue types. Most significant findings were derived from dorsolateral prefrontal cortex splicing data (n = 19 genes, 26%). The 17q21.31 inversion locus contained 23 significant associations, representing 6 unique genes. Other top hits included SEC22B (a gene involved in vesicle trafficking), TRGV5, and ZNF302. A single gene finding (RAB38) was observed for behavioral variant FTD. For other clinical subtypes, no significant associations were observed. Conclusions: We identified novel candidate genes (e.g., SEC22B) and previously reported risk regions (e.g., 17q21.31) for FTD. Most significant associations were observed in dorsolateral prefrontal cortex splicing data despite the modest sample size of this reference panel. This suggests that our findings are specific to FTD and are likely to be biologically relevant highlights of genes at different FTD risk loci that are contributing to the disease pathology.
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Keyword:
17q21.31 inversion region; Dorsolateral prefrontal cortex; Expression quantitative trait loci (eQTL); Frontotemporal dementia; SEC22B; Transcriptome-wide association study
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URL: https://doi.org/10.1016/j.biopsych.2020.12.023 http://hdl.handle.net/2318/1783267
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The Visual Word Form Area compensates for auditory working memory dysfunction in schizophrenia.
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In: Scientific reports, vol 10, iss 1 (2020)
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Natural Behavior and the Neurobiology of Primate Communication
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The neural underpinnings of shared meaning between speakers and listeners of naturalistic language ...
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Anticipatory feelings: Neural correlates and linguistic markers.
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In: Neuroscience and biobehavioral reviews, vol. 113, pp. 308-324 (2020)
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The influence of contextual constraint on verbal selection mechanisms and its neural correlates in Parkinson’s disease
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A Reservoir Model for Intra-Sentential Code-Switching Comprehension in French and English
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In: CogSci'19 - 41st Annual Meeting of the Cognitive Science Society ; https://hal.inria.fr/hal-02432831 ; CogSci'19 - 41st Annual Meeting of the Cognitive Science Society, Jul 2019, Montréal, Canada ; https://cognitivesciencesociety.org/cogsci-2019/ (2019)
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Multiscale Entropy Quantifies the Differential Effect of the Medium Embodiment on Older Adults Prefrontal Cortex during the Story Comprehension: A Comparative Analysis
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In: Entropy ; Volume 21 ; Issue 2 (2019)
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Balancing Prediction and Sensory Input in Speech Comprehension: The Spatiotemporal Dynamics of Word Recognition in Context. ...
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Paracingulate Sulcus Morphology and Hallucinations in Clinical and Nonclinical Groups. ...
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Proactive and Reactive Language Control in the Bilingual Brain
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In: Brain Sciences ; Volume 9 ; Issue 7 (2019)
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Paracingulate Sulcus Morphology and Hallucinations in Clinical and Nonclinical Groups.
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Balancing Prediction and Sensory Input in Speech Comprehension: The Spatiotemporal Dynamics of Word Recognition in Context.
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Brain activity during traditional textbook and audiovisual-3D learning
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Functional correlates of strategy formation and verbal suppression in Parkinson's disease
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