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Increased Pupil Size during Future Thinking in a Subject with Retrograde Amnesia
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In: Brain Sci (2022)
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Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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In: ISSN: 1664-2295 ; Frontiers in Neurology ; https://hal.inria.fr/hal-01897015 ; Frontiers in Neurology, Frontiers, 2018, 9, ⟨10.3389/fneur.2018.00766⟩ (2018)
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Structural, microstructural and metabolic alterations in Primary Progressive Aphasia variants
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In: Annual meeting of the Organization for Human Brain Mapping - OHBM 2018 ; https://hal.inria.fr/hal-01764289 ; Annual meeting of the Organization for Human Brain Mapping - OHBM 2018, Jun 2018, Singapore, Singapore (2018)
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Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants
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Primary Progressive Aphasia in the Network of French Alzheimer Plan Memory Centers
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Magnin, Eloi; Démonet, Jean-François; Wallon, David; Dumurgier, Julien; Troussière, Anne-Cécile; Jager, Alain; Duron, Emmanuelle; Gabelle, Audrey; De La Sayette, Vincent; Volpe-Gillot, Lisette; Tio, Gregory; Evain, Sarah; Boutoleau-Bretonnière, Claire; Enderle, Adeline; Mouton-Liger, François; Robert, Philippe; Hannequin, Didier; Pasquier, Florence; Hugon, Jacques; Paquet, Claire; collaborators, ePLM
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In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal.archives-ouvertes.fr/hal-01824840 ; Journal of Alzheimer's Disease, IOS Press, 2016, 54 (4), pp.1459 - 1471. ⟨10.3233/JAD-160536⟩ (2016)
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Abstract:
International audience ; BACKGROUND:Few demographical data about primary progressive aphasia (PPA) are available, and most knowledge regarding PPA is based on tertiary centers' results.OBJECTIVE:Our aims were to describe demographical characteristics of the PPA population in a large sample of PPA patients from the network of French Alzheimer plan memory centers (Sample 1), and to describe the stratification of cerebrospinal fluid (CSF) biomarkers in two different samples of PPA patients (Samples 2 and 3).METHODS:All registered PPA patients in the French Alzheimer's disease (AD) databank (Sample 1: n = 2,035) and a subsample (Sample 2: n = 65) derived from a multicentric prospective cohort with CSF biomarker analysis were analyzed. A multicentric retrospective cohort from language expert tertiary centers (Sample 3: n = 97) with CSF biomarker analysis was added. Sample 3 was added to replicate the CSF results of the Sample 2 and to evaluate repartition of AD pathology in the three variant of PPA according to the latest classification.RESULTS:Non-Fluent/Agrammatic, Logopenic, and Unclassifiable PPA patients (NF/A-Logo-Unclass PPA) were older and more frequent than Semantic PPA patients (2.2 versus 0.8/100,000 inhabitants; p < 0.00001). Male predominance occurred after the age of 80 (p < 0.00001). A higher level of education was observed in the PPA population compared to a typical amnesic AD group. No demographical significant difference between PPA due to AD and not due to AD was observed. The Logopenic variant was most frequent with 85% of AD CSF biomarker profiles (35% in NF/A PPA; 20% in Semantic PPA).CONCLUSION:PPA occurs also in an elderly population, especially in male patients over 80. CSF biomarkers are useful to stratify PPA. The epidemiology of PPA should be further investigated to confirm gender and cognitive reserve role in PPA to better understand the factors and mechanisms leading to this language-predominant deficit during neurodegenerative diseases.
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Keyword:
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; Alzheimer’s disease; cerebrospinal fluid biomarkers; epidemiology; frontotemporal dementia; gender; primary progressive aphasia
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URL: https://doi.org/10.3233/JAD-160536
https://hal.archives-ouvertes.fr/hal-01824840
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Primary Progressive Aphasia in the Network of French Alzheimer Plan Memory Centers
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In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630200 ; Journal of Alzheimer's Disease, IOS Press, 2016, 54 (4), pp.1459-1471. ⟨10.3233/JAD-160536⟩ (2016)
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Theory of mind and linguistic pragmatic difficulties in behavioural-variant frontotemporal dementia
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In: 9th International Conference on Frontotemporal Dementias (ICFTD) ; https://hal.univ-rennes2.fr/hal-01982456 ; 9th International Conference on Frontotemporal Dementias (ICFTD), Oct 2014, Vancouver, Canada (2014)
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