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Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases.
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In: European journal of nuclear medicine and molecular imaging, vol 48, iss 7 (2021)
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Identification of Mood-Relevant Brain Connections Using a Continuous, Subject-Driven Rumination Paradigm
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Abstract:
Rumination, an internal cognitive state characterized by recursive thinking of current self-distress and past negative events, has been found to correlate with the development of depressive disorders. Here, we investigated the feasibility of using connectivity for distinguishing different emotional states induced by a novel free-streaming, subject-driven experimental paradigm. Connectivity between 78 functional regions of interest (ROIs) within 14 large-scale networks and 6 structural ROIs particularly relevant to emotional processing were used for classifying 4 mental states in 19 healthy controls. The 4 mental states comprised: An unconstrained period of mind wandering; a ruminative mental state self-induced by recalling a time of personal disappointment; a euphoric mental state self-induced by recalling what brings the subject joy; and a sequential episodic recollection of the events of the day. A support vector machine achieved accuracies ranging from 89% to 94% in classifying pairs of different mental states. We reported the most significant brain connections that best discriminated these mental states. In particular, connectivity changes involving the amygdala were found to be important for distinguishing the rumination condition from the other mental states. Our results demonstrated that connectivity-based classification of subject-driven emotional states constitutes a novel and effective approach for studying ruminative behavior.
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Original Articles
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URL: https://doi.org/10.1093/cercor/bhu255 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737600/ http://www.ncbi.nlm.nih.gov/pubmed/25331601
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Loss of functional connectivity is greater outside the default mode network in non-familial early-onset Alzheimer’s disease variants
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Identification of Mood-Relevant Brain Connections Using a Continuous, Subject-Driven Rumination Paradigm.
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In: ISSN: 1047-3211 ; EISSN: 1460-2199 ; Cerebral Cortex ; https://hal.inria.fr/hal-01094759 ; Cerebral Cortex, Oxford University Press (OUP), 2014, pp.12 (2014)
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Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia.
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In: JAMA neurology, vol 70, iss 2 (2013)
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Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia.
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In: JAMA neurology, vol 70, iss 2 (2013)
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Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease
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Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease
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Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia
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Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer’s disease
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Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease
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