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When does speech sound disorder matter for literacy? : The role of disordered speech errors, co-occurring language impairment, and family-risk of dyslexia
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Automatic Activation of Sounds by Letters Occurs Early in Development but is not Impaired in Children With Dyslexia
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Are the literacy difficulties that characterize developmental dyslexia associated with a failure to integrate letters and speech sounds?
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The phonological neighbourhood effect on short-term memory for order
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In: Faculty of Social Sciences - Papers (2017)
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Pettigrew, Kerry Andrea; Frinton, Emily; Nudel, Ron; Chan, May T. M.; Thompson, Paul; Hayiou-Thomas, Marianna E.; Talcott, Joel B.; Stein, John; Monaco, Anthony P.; Hulme, Charles; Snowling, Margaret J.; Newbury, Diane F.; Paracchini, Silvia. - 2016
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Abstract:
SP is a Royal Society University Research Fellow. Support to the analysis was provided by the St Andrews Bioinformatics Unit funded by the Wellcome Trust [grant 097831/Z/11/Z]. Analysis of the cohort was supported by a Wellcome Trust Programme Grant to MJS [WT082032MA]. EF is the recipient of a Wolfson Intercalated Award. MTMC is the recipient of the Wilkinson Junior Research Fellowship at Worcester College, Oxford and was funded by the Esther Yewpick Lee Millennium Scholarship. RN was funded by a University of Oxford Nuffield Department of Medicine Prize Studentship. DFN is an MRC Career Development Fellow. The work of the Newbury lab is funded by the Medical Research Council [G1000569/1 and MR/J003719/1]. The work of the Wellcome Trust Centre in Oxford is supported by the Wellcome Trust [090532/Z/09/Z]. ; Background: Specific Language Impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10% of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have been reported to date. A recent genome-wide association study (GWAS) described the first statistically significant association specifically for a SLI cohort between a missense variant (rs4280164) in the NOP9 gene and language-related phenotypes under a parent-of-origin model. Replications of these findings are particularly challenging because the availability of parental DNA is required. Methods: We used two independent family-based cohorts characterised with reading- and language-related traits: a longitudinal cohort (n = 106 informative families) including children with language and reading difficulties and a nuclear family cohort (n = 264 families) selected for dyslexia. Results: We observed association with languagerelated measures when modelling for parent-of-origin effects at the NOP9 locus in both cohorts: minimum P = 0.001 for phonological awareness with a paternal effect in the first cohort and minimum P = 0.0004 for irregular word reading with a maternal effect in the second cohort. Allelic and parental trends were not consistent when compared to the original study. Conclusions: A parent-of-origin effect at this locus was detected in both cohorts, albeit with different trends. These findings contribute in interpreting the original GWAS report and support further investigations of the NOP9 locus and its role in language-related traits. A systematic evaluation of parent-of-origin effects in genetic association studies has the potential to reveal novel mechanisms underlying complex traits. ; Publisher PDF ; Peer reviewed
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Keyword:
Candidate gene; Dyslexia; Genetic association; Language impairement; NDAS; Parent-of-origin; RC0321; RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
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URL: http://hdl.handle.net/10023/8991
https://doi.org/10.1186/s11689-016-9157-6
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Preschool morphological training produces long-term improvements in reading comprehension
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Precursors of reading difficulties in Czech and Slovak children at-risk of dyslexia
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The development of executive function and language skills in the early school years
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Copy Number Variation Screen Identifies a Rare De Novo Deletion at Chromosome 15q13.1-13.3 in a Child with Language Impairment
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Early language and executive skills predict variations in number and arithmetic skills in children at family-risk of dyslexia and typically developing controls
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Copy number variation screen identifies a rare de novo deletion at chromosome 15q13.1-13.3 in a child with language impairment
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The Foundations of Literacy Development in Children at Familial Risk of Dyslexia
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Copy number variation screen identifies a rare de novo deletion at chromosome 15q13.1-13.3 in a child with language impairment
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