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Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study
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In: GeroScience (2021)
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Abstract:
Alzheimer’s disease (AD) is the most common neurodegenerative disorder in elderly subjects. Recent studies verified the effects of cognitive training combined with repetitive transcranial magnetic stimulation (rTMS-COG) in AD patients. Here, we analyzed neuropsychological and neurophysiological data, derived from electroencephalography (EEG), to evaluate the effects of a 6-week protocol of rTMS-COG in 72 AD. We designed a randomized, double-blind, sham-controlled trial to evaluate efficacy of rTMS on 6 brain regions obtained by an individual MRI combined with COG related to brain areas to stimulate (i.e., syntax and grammar tasks, comprehension of lexical meaning and categorization tasks, action naming, object naming, spatial memory, spatial attention). Patients underwent neuropsychological and EEG examination before (T(0)), after treatment (T(1)), and after 40 weeks (T(2)), to evaluate the effects of rehabilitation therapy. “Small World” (SW) graph approach was introduced allowing us to model the architecture of brain connectivity in order to correlate it with cognitive improvements. We found that following 6 weeks of intensive daily treatment the immediate results showed an improvement in cognitive scales among AD patients. SW present no differences before and after the treatment, whereas a crucial SW modulation emerges at 40-week follow-up, emphasizing the importance of rTMS-COG rehabilitation treatment for AD. Additional results demonstrated that the delta and alpha1 SW seem to be diagnostic biomarkers of AD, whereas alpha2 SW might represent a prognostic biomarker of cognitive recovery. Derived EEG parameters can be awarded the role of diagnostic and predictive biomarkers of AD progression, and rTMS-COG can be regarded as a potentially useful treatment for AD.
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Original Article
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URL: https://doi.org/10.1007/s11357-021-00508-w http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811083/ http://www.ncbi.nlm.nih.gov/pubmed/34970718
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Mouth Gestures and Mouthing in Two Sign Languages (LIS and LSF)
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In: Theoretical Issues in Sign Language Research Conference (TISLR 11) ; https://hal.archives-ouvertes.fr/hal-01712936 ; Theoretical Issues in Sign Language Research Conference (TISLR 11), Jul 2013, London, United Kingdom (2013)
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Mouth Gestures and Mouthing in Two Sign Languages (LIS and LSF). ...
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Unilateral cortical hyperexcitability in congenital hydrocephalus: A TMS study
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Lexematic units and highly iconic structures in Italian sign language: new methods of analysis aided by ad hoc software ...
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Lateralization of Dichotic Speech Stimuli is Based on Specific Auditory Pathway Interactions: Neuromagnetic Evidence
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Deixis, Anaphora and Highly Iconic Structures: Cross-linguistic Evidence on American (ASL), French (LSF) and Italian (LIS) Signed Languages
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In: Sign Languages: spinning and unraveling the past, present and future. ; TISLR9 ; https://hal.archives-ouvertes.fr/hal-00617907 ; TISLR9, Dec 2006, Florianopolis, Brazil. pp.475-495 (2006)
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Deixis, Anaphora and Highly Iconic Structures: Crosslinguistic Evidence on American (ASL), French (LSF) and Italian (LIS) Signed Languages
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In: Sign Languages: spinning and unraveling the past, present and future. TISLR9, forty five papers and three posters from the 9th. Theoretical Issues in Sign Language Research Conference. ; Theoretical Issues in Sign Language Research Conference 9 (TISLR9) Sign Languages: spinning and unraveling the past, present and future. ; https://halshs.archives-ouvertes.fr/halshs-00382566 ; Theoretical Issues in Sign Language Research Conference 9 (TISLR9)Sign Languages: spinning and unraveling the past, present and future., Dec 2006, Florianapolis, Brazil. pp.475-495 (2006)
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Deixis, Anaphora and Highly Iconic Structures: Cross-linguistic Evidence on American (ASL), French (LSF) and Italian (LIS) Signed Languages ...
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Lateralization of Dichotic Speech Stimuli is Based on Specific Auditory Pathway Interactions: Neuromagnetic Evidence
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Lateralization of Dichotic Speech Stimuli is Based on Specific Auditory Pathway Interactions: Neuromagnetic Evidence
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Transcranial magnetic stimulation : proceedings of the International Symposium on Transcranial Magnetic Stimulation, Göttingen, 30 September to 4 October 1998 . - Electroencephalography and clinical neurophysiology ; suppl. 51 : Transcranial magnetic stimulation : proceedings of the International Symposium on Transcranial Magnetic Stimulation, Göttingen, 30 September to 4 October 1998 . -
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MPI für Psycholinguistik
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