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1
Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study
In: GeroScience (2021)
Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative disorder in elderly subjects. Recent studies verified the effects of cognitive training combined with repetitive transcranial magnetic stimulation (rTMS-COG) in AD patients. Here, we analyzed neuropsychological and neurophysiological data, derived from electroencephalography (EEG), to evaluate the effects of a 6-week protocol of rTMS-COG in 72 AD. We designed a randomized, double-blind, sham-controlled trial to evaluate efficacy of rTMS on 6 brain regions obtained by an individual MRI combined with COG related to brain areas to stimulate (i.e., syntax and grammar tasks, comprehension of lexical meaning and categorization tasks, action naming, object naming, spatial memory, spatial attention). Patients underwent neuropsychological and EEG examination before (T(0)), after treatment (T(1)), and after 40 weeks (T(2)), to evaluate the effects of rehabilitation therapy. “Small World” (SW) graph approach was introduced allowing us to model the architecture of brain connectivity in order to correlate it with cognitive improvements. We found that following 6 weeks of intensive daily treatment the immediate results showed an improvement in cognitive scales among AD patients. SW present no differences before and after the treatment, whereas a crucial SW modulation emerges at 40-week follow-up, emphasizing the importance of rTMS-COG rehabilitation treatment for AD. Additional results demonstrated that the delta and alpha1 SW seem to be diagnostic biomarkers of AD, whereas alpha2 SW might represent a prognostic biomarker of cognitive recovery. Derived EEG parameters can be awarded the role of diagnostic and predictive biomarkers of AD progression, and rTMS-COG can be regarded as a potentially useful treatment for AD.
Keyword: Original Article
URL: https://doi.org/10.1007/s11357-021-00508-w
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811083/
http://www.ncbi.nlm.nih.gov/pubmed/34970718
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2
Sign language representation : new approaches to the study of Italian Sign Language (LIS)
In: Sign language research, uses and practices (Berlin, 2013), p. 137-158
MPI für Psycholinguistik
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3
Mouth Gestures and Mouthing in Two Sign Languages (LIS and LSF)
In: Theoretical Issues in Sign Language Research Conference (TISLR 11) ; https://hal.archives-ouvertes.fr/hal-01712936 ; Theoretical Issues in Sign Language Research Conference (TISLR 11), Jul 2013, London, United Kingdom (2013)
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4
Mouth Gestures and Mouthing in Two Sign Languages (LIS and LSF). ...
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5
Unilateral cortical hyperexcitability in congenital hydrocephalus: A TMS study
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6
Lexematic units and highly iconic structures in Italian sign language: new methods of analysis aided by ad hoc software ...
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7
Grammaticalization in sign languages
In: Sign languages (Cambridge, 2010), p. 332-354
MPI für Psycholinguistik
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8
Grammaticalization in sign languages
In: Sign languages. - Cambridge [u.a.] : Cambridge Univ. Press (2010), 332-354
BLLDB
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9
La struttura del discorso segnato: dati sulla LIS, l'ASL e la LSF, e nuove prospettive nel quadro di una grammatica dell'iconicità
In: I segni parlano: prospettive di ricerca sulla Lingua dei Segni Italiana. - Milano : Angeli (2008), 43-53
BLLDB
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10
Lateralization of Dichotic Speech Stimuli is Based on Specific Auditory Pathway Interactions: Neuromagnetic Evidence
Della Penna, Stefania; Brancucci, Alfredo; Babiloni, Claudio. - : Oxford University Press, 2007
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11
Deixis, Anaphora and Highly Iconic Structures: Cross-linguistic Evidence on American (ASL), French (LSF) and Italian (LIS) Signed Languages
In: Sign Languages: spinning and unraveling the past, present and future. ; TISLR9 ; https://hal.archives-ouvertes.fr/hal-00617907 ; TISLR9, Dec 2006, Florianopolis, Brazil. pp.475-495 (2006)
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12
Deixis, Anaphora and Highly Iconic Structures: Crosslinguistic Evidence on American (ASL), French (LSF) and Italian (LIS) Signed Languages
In: Sign Languages: spinning and unraveling the past, present and future. TISLR9, forty five papers and three posters from the 9th. Theoretical Issues in Sign Language Research Conference. ; Theoretical Issues in Sign Language Research Conference 9 (TISLR9) Sign Languages: spinning and unraveling the past, present and future. ; https://halshs.archives-ouvertes.fr/halshs-00382566 ; Theoretical Issues in Sign Language Research Conference 9 (TISLR9)Sign Languages: spinning and unraveling the past, present and future., Dec 2006, Florianapolis, Brazil. pp.475-495 (2006)
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13
Deixis, Anaphora and Highly Iconic Structures: Cross-linguistic Evidence on American (ASL), French (LSF) and Italian (LIS) Signed Languages ...
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14
Lateralization of Dichotic Speech Stimuli is Based on Specific Auditory Pathway Interactions: Neuromagnetic Evidence
Della Penna, Stefania; Brancucci, Alfredo; Babiloni, Claudio. - : Oxford University Press, 2006
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15
Lateralization of Dichotic Speech Stimuli is Based on Specific Auditory Pathway Interactions: Neuromagnetic Evidence
Penna, Stefania Della; Brancucci, Alfredo; Babiloni, Claudio. - : Oxford University Press, 2006
BASE
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16
The role of prefrontal cortex in verbal episodic memory : rTMS evidence
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 15 (2003) 6, 855-861
BLLDB
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17
The Role of Prefrontal Cortex in Verbal Episodic Memory: rTMS Evidence
In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 15 (2003) 6, 855-861
OLC Linguistik
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18
Transcranial magnetic stimulation : proceedings of the International Symposium on Transcranial Magnetic Stimulation, Göttingen, 30 September to 4 October 1998 . - Electroencephalography and clinical neurophysiology ; suppl. 51 : Transcranial magnetic stimulation : proceedings of the International Symposium on Transcranial Magnetic Stimulation, Göttingen, 30 September to 4 October 1998 . -
MPI für Psycholinguistik
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19
Evaluation of human central motor pathways by magnetic stimulation : characterization of conductivity and exitability in a clinical context
In: Magnetic stimulation in clinical neurophysiology (London, 1990), p. 145-156
MPI für Psycholinguistik
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