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Blueberry Supplementation in Midlife for Dementia Risk Reduction
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In: Nutrients; Volume 14; Issue 8; Pages: 1619 (2022)
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Verbal Fluency in Metabolic Syndrome
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In: Brain Sciences; Volume 12; Issue 2; Pages: 255 (2022)
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Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follow-up in the PREDIMED-Plus Study
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Abstract:
The authors wish to thank the PREDIMED-Plus participants and staff for their engagement, as well as to the primary care centers involved in the study. We also thank the Cerca Programme of the Generalitat de Catalunya, and the CIBEROBN, CIBERESP and CIBERDEM initiatives of Instituto de Salud Carlos III in Spain, and the collaborators in the PRIME consortium for helpful input. The first version of the present article has been published in the public repository Research Square as a preprint publication of our work (44). We particularly thank Stephanie Nishi for her assistance with manuscript language revision. ; Introduction: Type 2 diabetes has been linked to greater cognitive decline, but other glycemic parameters such as prediabetes, diabetes control and treatment, and HOMA-IR and HbA1c diabetes-related biomarkers have shown inconsistent results. Furthermore, there is limited research assessing these relationships in short-term studies. Thus, we aimed to examine 2-year associations between baseline diabetes/glycemic status and changes in cognitive function in older participants at high risk of cardiovascular disease. Methods: We conducted a 2-year prospective cohort study (n=6,874) within the framework of the PREDIMED-Plus study. The participants (with overweight/obesity and metabolic syndrome; mean age 64.9 years; 48.5% women) completed a battery of 8 cognitive tests, and a global cognitive function Z-score (GCF) was estimated. At baseline, participants were categorized by diabetes status (no-diabetes, prediabetes, and <5 or ≥5-year diabetes duration), and also by diabetes control. Furthermore, insulin resistance (HOMA-IR) and glycated hemoglobin (HbA1c) levels were measured, and antidiabetic medications were recorded. Linear and logistic regression models, adjusted by potential confounders, were fitted to assess associations between glycemic status and changes in cognitive function. Results: Prediabetes status was unrelated to cognitive decline. However, compared to participants without diabetes, those with ≥5-year diabetes duration had greater reductions in GCF (β=-0.11 (95%CI -0.16;-0.06)], as well as in processing speed and executive function measurements. Inverse associations were observed between baseline HOMA-IR and changes in GCF [β=-0.0094 (95%CI -0.0164;-0.0023)], but also between HbA1c levels and changes in GCF [β=-0.0085 (95%CI -0.0115, -0.0055)], the Mini-Mental State Examination, and other executive function tests. Poor diabetes control was inversely associated with phonologic fluency. The use of insulin treatment was inversely related to cognitive function as measured by the GCF [β=-0.31 (95%CI -0.44, -0.18)], and other cognitive tests. Conclusions: Insulin resistance, diabetes status, longer diabetes duration, poor glycemic control, and insulin treatment were associated with worsening cognitive function changes in the short term in a population at high cardiovascular risk. Clinical Trial Registration: http://www.isrctn.com/ISRCTN89898870, identifier ISRCTN: 89898870. ; CIBERESP ; Generalitat de Catalunya ; Instituto de Salud Carlos III ; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
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Keyword:
Cognitive function; Diabetes duration; Glycated (glycosylated) hemoglobin; Insulin resistance; Prediabetes; Type 2 diabetes
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URL: http://hdl.handle.net/10481/71819
https://doi.org/10.3389/fendo.2021.754347
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| 4 |
The newly developed signs in South African Sign Language for medical terms regarding diabetes ...
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The newly developed signs in South African Sign Language for medical terms regarding diabetes ...
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Children's biobehavioral reactivity to challenge predicts DNA methylation in adolescence and emerging adulthood.
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In: Developmental science, vol 22, iss 2 (2019)
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Branched-Chain Amino Acid Database Integrated in MEDIPAD Software as a Tool for Nutritional Investigation of Mediterranean Populations
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In: ISSN: 2072-6643 ; Nutrients ; https://hal-riip.archives-ouvertes.fr/pasteur-01989178 ; Nutrients, MDPI, 2018, 10 (10), pp.1392. ⟨10.3390/nu10101392⟩ (2018)
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Branched-chain amino acid database integrated in MEDIPAD software as a tool for nutritional investigation of Mediterranean populations
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Branched-Chain Amino Acid Database Integrated in MEDIPAD Software as a Tool for Nutritional Investigation of Mediterranean Populations
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In: Nutrients ; Volume 10 ; Issue 10 (2018)
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Branched-chain amino acid database integrated in MEDIPAD software as a tool for nutritional investigation of mediterranean populations
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Biosimilarity and Interchangeability: Principles and Evidence: A Systematic Review
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Branched-chain amino acid database integrated in MEDIPAD software as a tool for nutritional investigation of mediterranean populations
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L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development.
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| 14 |
Starch-Based Diet and Type 2 Diabetes
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In: Journal of Health Disparities Research and Practice (2016)
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Traditional Medicine as a Treatment for Type II Diabetes Mellitus
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In: Journal of Health Disparities Research and Practice (2016)
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Effective communication is crucial to self-management: The experiences of immigrants to Australia living with diabetes
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In: Chronic Illness (2015)
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| 17 |
Basal insulin and cardiovascular and other outcomes in dysglycemia.
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In: New England Journal of Medicine, vol. 367, no. 4, pp. 319-328 (2012)
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n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia.
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In: New England Journal of Medicine, vol. 367, no. 4, pp. 309-318 (2012)
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Surviving the Perfect Storm of Diabetes in the World of the Schitsu'umsh
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| 20 |
IDENTIFICATION AND CHARACTERIZATION OF REGULATORS OF THE LONGEVITY FACTOR DAF-16 IN C. ELEGANS
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