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Cortical microstructure in primary progressive aphasia: a multicenter study.
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Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi; Mandelli, Maria Luisa; Falgàs, Neus; Welch, Ariane E; Pegueroles, Jordi; Santos-Santos, Miguel; Bejanin, Alexandre; Alcolea, Daniel; Dols-Icardo, Oriol; Belbin, Olivia; Sánchez-Saudinós, Mª Belén; Bargalló, Nuria; González-Ortiz, Sofía; Lladó, Albert; Blesa, Rafael; Dickerson, Bradford C; Rosen, Howard J; Miller, Bruce L; Lleó, Alberto; Gorno-Tempini, Maria Luisa; Sánchez-Valle, Raquel; Fortea, Juan
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Abstract:
BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).MethodsIn this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.ResultsThe comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.ConclusionsCortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA.
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Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Biomedical Imaging; Brain Disorders; Case-Control Studies; Clinical Research; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Frontotemporal Dementia (FTD); Frontotemporal lobar degeneration; Humans; Magnetic resonance; Magnetic Resonance Imaging; Medical and Health Sciences; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Primary progressive aphasia; Rare Diseases
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URL: https://escholarship.org/uc/item/4td346vg
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| 2 |
A Preliminary Report of Network Electroencephalographic Measures in Primary Progressive Apraxia of Speech and Aphasia
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In: Brain Sciences; Volume 12; Issue 3; Pages: 378 (2022)
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| 3 |
Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy
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In: Life; Volume 12; Issue 5; Pages: 662 (2022)
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| 4 |
A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
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| 5 |
A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
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| 6 |
Improving the diagnostic accuracy of primary progressive aphasia using cognitive tests
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Foxe, David Gordon. - : The University of Sydney, 2022. : Faculty of Science, School of Psychology, 2022
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| 7 |
Neural substrates of verbal repetition deficits in primary progressive aphasia.
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| 8 |
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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| 9 |
Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
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| 10 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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| 11 |
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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| 12 |
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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| 13 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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| 14 |
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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| 15 |
Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis
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In: Brain Sciences ; Volume 11 ; Issue 9 (2021)
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Survival in the Three Common Variants of Primary Progressive Aphasia: A Retrospective Study in a Tertiary Memory Clinic
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In: Brain Sciences ; Volume 11 ; Issue 9 (2021)
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| 17 |
Application of Machine Learning to Electroencephalography for the Diagnosis of Primary Progressive Aphasia: A Pilot Study
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In: Brain Sciences ; Volume 11 ; Issue 10 (2021)
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| 18 |
Longitudinal Changes in Cognition, Behaviours, and Functional Abilities in the Three Main Variants of Primary Progressive Aphasia: A Literature Review
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In: Brain Sciences ; Volume 11 ; Issue 9 (2021)
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| 19 |
Verbal Short-Term Memory Disturbance in the Primary Progressive Aphasias: Challenges and Distinctions in a Clinical Setting
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In: Brain Sciences ; Volume 11 ; Issue 8 (2021)
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| 20 |
Treatment for Anomia in Bilingual Speakers with Progressive Aphasia
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In: Brain Sciences ; Volume 11 ; Issue 11 (2021)
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