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Taking the sublexical route: brain dynamics of reading in the semantic variant of primary progressive aphasia
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In: Brain (2020)
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Task-Free Functional Language Networks: Reproducibility and Clinical Application
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In: J Neurosci (2020)
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Conceptual and Perceptual Dimensions of Word Meaning Are Recovered Rapidly and in Parallel during Reading
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In: ISSN: 0898-929X ; EISSN: 1530-8898 ; Journal of Cognitive Neuroscience ; https://hal.sorbonne-universite.fr/hal-01978688 ; Journal of Cognitive Neuroscience, Massachusetts Institute of Technology Press (MIT Press), 2019, 31 (1), pp.95-108. ⟨10.1162/jocn_a_01328⟩ (2019)
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Cortical dynamics of the speech motor control network in the non-fluent variant of Primary Progressive Aphasia ...
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Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia
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Battistella, Giovanni; Henry, Maya; Gesierich, Benno; Wilson, Stephen M.; Borghesani, Valentina; Shwe, Wendy; Miller, Zachary; Deleon, Jessica; Miller, Bruce L.; Jovicich, Jorge; Papinutto, Nico; Dronkers, Nina F.; Seeley, William W.; Mandelli, Maria Luisa; Gorno-Tempini, Maria Luisa. - : Elsevier, 2019
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Abstract:
The semantic variant of primary progressive aphasia (svPPA) is a clinical syndrome characterized by semantic memory deficits with relatively preserved motor speech, syntax, and phonology. There is consistent evidence linking focal neurodegeneration of the anterior temporal lobes (ATL) to the semantic deficits observed in svPPA. Less is known about large-scale functional connectivity changes in this syndrome, particularly regarding the interplay between affected and spared language networks that leads to the unique cognitive dissociations typical of svPPA. Using whole-brain, seed-based connectivity on task-free Magnetic Resonance Imaging (MRI) data, we studied connectivity of networks anchored to three left-hemisphere regions crucially involved in svPPA symptomatology: ATL just posterior to the main atrophic area, opercular inferior frontal gyrus, and posterior inferior temporal lobe. First, in 32 healthy controls, these seeds isolated three networks: a ventral semantic network involving anterior middle temporal and angular gyri, a dorsal articulatory-phonological system involving inferior frontal and supramarginal regions, and a third functional connection between posterior inferior temporal and intraparietal regions likely involved in linking visual and linguistic processes. We then compared connectivity strength of these three networks between 16 svPPA patients and the 32 controls. In svPPA, decreased functional connectivity in the ventral semantic network correlated with weak semantic skills, while connectivity of the network seeded from the posterior inferior temporal lobe, though not significantly different between the two groups, correlated with pseudoword reading skills. Increased connectivity between the inferior frontal gyrus and the superior portion of the angular gyrus suggested possible adaptive changes. Our findings have two main implications. First, they support a functional subdivision of the left IPL based on its connectivity to specific language-related regions. Second, the unique neuroanatomical and linguistic profile observed in svPPA provides a compelling model for the functional interplay of these networks, being either up- or down- regulated in response to disease.
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Keyword:
Regular Article
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URL: https://doi.org/10.1016/j.nicl.2019.101797 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465769/
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“Looks familiar, but I do not know who she is”: The role of the anterior right temporal lobe in famous face recognition
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Verbal Semantics and the Left Dorsolateral Anterior Temporal Lobe: A Longitudinal Case of Bilateral Temporal Degeneration
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In: Aphasiology (2019)
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The Neural Representations of Movement across Semantic Categories
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Word meaning in the ventral visual path: a perceptual to conceptual gradient of semantic coding
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In: ISSN: 1053-8119 ; EISSN: 1095-9572 ; NeuroImage ; https://hal.sorbonne-universite.fr/hal-01372551 ; NeuroImage, Elsevier, 2016, ⟨10.1016/j.neuroimage.2016.08.068⟩ (2016)
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A perceptual-to-conceptual gradient of word coding along the ventral path
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In: PRNI 2014 - 4th International Workshop on Pattern Recognition in NeuroImaging ; https://hal.inria.fr/hal-00986606 ; PRNI 2014 - 4th International Workshop on Pattern Recognition in NeuroImaging, Jun 2014, Tubingen, Germany (2014)
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