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A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
Patel, Nikil; Peterson, Katie A; Ingram, Ruth U. - : Apollo - University of Cambridge Repository, 2022
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A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
Patel, Nikil; Peterson, Katie A; Ingram, Ruth U. - : Apollo - University of Cambridge Repository, 2022
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3
Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. ...
Peterson, Katie A; Jones, P Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021
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Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. ...
Peterson, Katie; Jones, Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021
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5
Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool ...
Peterson, Katie A.; Jones, P. Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021
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6
Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool
In: Front Aging Neurosci (2021)
Abstract: Background: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) affect speech and language as well as motor functions. Clinical and neuropathological data indicate a close relationship between these two disorders and the non-fluent variant of primary progressive aphasia (nfvPPA). We use the recently developed Mini Linguistic State Examination tool (MLSE) to study speech and language disorders in patients with PSP, CBS, and nfvPPA, in combination with structural magnetic resonance imaging (MRI). Methods: Fifty-one patients (PSP N = 13, CBS N = 19, nfvPPA N = 19) and 30 age-matched controls completed the MLSE, the short form of the Boston Diagnostic Aphasia Examination (BDAE), and the Addenbrooke’s Cognitive Examination III. Thirty-eight patients and all controls underwent structural MRI at 3 Tesla, with T1 and T2-weighted images processed by surface-based and subcortical segmentation within FreeSurfer 6.0.0 to extract cortical thickness and subcortical volumes. Morphometric differences were compared between groups and correlated with the severity of speech and language impairment. Results: CBS and PSP patients showed impaired MLSE performance, compared to controls, with a similar language profile to nfvPPA, albeit less severe. All patient groups showed reduced cortical thickness in bilateral frontal regions and striatal volume. PSP and nfvPPA patients also showed reduced superior temporal cortical thickness, with additional thalamic and amygdalo-hippocampal volume reductions in nfvPPA. Multivariate analysis of brain-wide cortical thickness and subcortical volumes with MLSE domain scores revealed associations between performance on multiple speech and language domains with atrophy of left-lateralised fronto-temporal cortex, amygdala, hippocampus, putamen, and caudate. Conclusions: The effect of PSP and CBS on speech and language overlaps with nfvPPA. These three disorders cause a common anatomical pattern of atrophy in the left frontotemporal language network and striatum. The MLSE is a short clinical screening tool that can identify the language disorder of PSP and CBS, facilitating clinical management and patient access to future clinical trials.
Keyword: Neuroscience
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351757/
http://www.ncbi.nlm.nih.gov/pubmed/34381350
https://doi.org/10.3389/fnagi.2021.675739
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Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool
Peterson, Katie A.; Jones, P. Simon; Patel, Nikil. - : Frontiers Media S.A., 2021. : Frontiers in Aging Neuroscience, 2021
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8
Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool.
In: essn: 1663-4365 ; nlmid: 101525824 (2021)
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9
Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool.
Peterson, Katie; Jones, Simon; Patel, Nikil. - : Frontiers Media SA, 2021. : Front Aging Neurosci, 2021
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10
In search of different categories of abstract concepts: a fMRI adaptation study
In: Sci Rep (2021)
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11
The Role of Neuropsychological Factors in Perceived Threat of SARS-CoV-2 in Healthy Ageing
In: Int J Environ Res Public Health (2021)
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The Role of Neuropsychological Factors in Perceived Threat of SARS-CoV-2 in Healthy Ageing
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13
High gamma response tracks different syntactic structures in homophonous phrases
In: http://infoscience.epfl.ch/record/277719 (2020)
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14
Effectiveness of language training and non-invasive brain stimulation on oral and written naming performance in Primary Progressive Aphasia: a meta-analysis and systematic review
Cotelli, Maria; Manenti, Rosa; Ferrari, C.. - : Elsevier Ltd, 2020
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15
Speech production differences in English and Italian speakers with nonfluent variant PPA
In: Neurology (2020)
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16
High gamma response tracks different syntactic structures in homophonous phrases
In: Sci Rep (2020)
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17
Cognitive telerehabilitation in mild cognitive impairment, Alzheimer’s disease and frontotemporal dementia: a systematic review
Cotelli, Maria; Manenti, Rosa; Brambilla, Michela. - : SAGE Publications Ltd, 2019
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18
The clinico-metabolic correlates of language impairment in corticobasal syndrome and progressive supranuclear palsy
In: ISSN: 2213-1582 ; NeuroImage: Clinical (2019) P. 102009 (2019)
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19
Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia
In: Cortex (2019)
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20
Morpho-syntactic complexity modulates brain activation in Persian-English bilinguals: An fMRI study
In: ISSN: 0093-934X ; Brain and Language, Vol. 185 (2018) pp. 9-18 (2018)
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