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Gene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes
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The trans-ancestral genomic architecture of glycemic traits.
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In: Nature genetics, vol. 53, no. 6, pp. 840-860 (2021)
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility Gene
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In: Genes ; Volume 10 ; Issue 12 (2019)
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Spatially explicit analysis reveals complex human genetic gradients in the Iberian Peninsula
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Enrichment of genetic markers of recent human evolution in educational and cognitive traits.
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Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J; Thompson, Wesley K; Davies, Gail; Desikan, Rahul S; Deary, Ian J; Melle, Ingrid; Ueland, Torill; Dale, Anders M; Djurovic, Srdjan; Smeland, Olav B; Andreassen, Ole A
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In: Scientific reports, vol 8, iss 1 (2018)
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Abstract:
Higher cognitive functions are regarded as one of the main distinctive traits of humans. Evidence for the cognitive evolution of human beings is mainly based on fossil records of an expanding cranium and an increasing complexity of material culture artefacts. However, the molecular genetic factors involved in the evolution are still relatively unexplored. Here, we investigated whether genomic regions that underwent positive selection in humans after divergence from Neanderthals are enriched for genetic association with phenotypes related to cognitive functions. We used genome wide association data from a study of college completion (N = 111,114), one of educational attainment (N = 293,623) and two different studies of general cognitive ability (N = 269,867 and 53,949). We found nominally significant polygenic enrichment of associations with college completion (p = 0.025), educational attainment (p = 0.043) and general cognitive ability (p = 0.015 and 0.025, respectively), suggesting that variants influencing these phenotypes are more prevalent in evolutionarily salient regions. The enrichment remained significant after controlling for other known genetic enrichment factors, and for affiliation to genes highly expressed in the brain. These findings support the notion that phenotypes related to higher order cognitive skills typical of humans have a recent genetic component that originated after the separation of the human and Neanderthal lineages.
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Keyword:
Biochemistry and Cell Biology; Biological Evolution; Biotechnology; Brain; Clinical Research; Cognition; Educational Status; Female; Genetic Markers; Genetics; Genome; Genome-Wide Association Study; Human Genome; Humans; Intelligence; Male; Mental Health; Multifactorial Inheritance; Other Physical Sciences; Phenotype; Polymorphism; Single Nucleotide
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URL: https://escholarship.org/uc/item/1n9569p1
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
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In: Nature genetics, vol 50, iss 7 (2018)
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Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
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In: Twin research and human genetics : the official journal of the International Society for Twin Studies, vol 21, iss 5 (2018)
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Global genetic differentiation of complex traits shaped by natural selection in humans.
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In: Nature communications, vol. 9, no. 1, pp. 1865 (2018)
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.
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In: Molecular psychiatry, vol 22, iss 3 (2017)
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DISSECTING THE GENETICS OF HUMAN COMMUNICATION: INSIGHTS INTO SPEECH, LANGUAGE, AND READING
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In: http://rave.ohiolink.edu/etdc/view?acc_num=case1473337776061224 (2017)
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Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families.
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In: American journal of human genetics, vol 99, iss 3 (2016)
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| 15 |
Evaluation of results from genome-wide studies of language and reading in a novel independent dataset.
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| 16 |
Tumor size and survival in multicentric and multifocal breast cancer
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In: The Breast (2015)
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Aspects of speech-language abilities are influenced by MECP2 mutation type in girls with Rett syndrome
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In: Research outputs 2014 to 2021 (2015)
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Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study
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