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Gene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes
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The trans-ancestral genomic architecture of glycemic traits.
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In: Nature genetics, vol. 53, no. 6, pp. 840-860 (2021)
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.
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In: Molecular psychiatry, vol 25, iss 10 (2020)
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Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility Gene
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In: Genes ; Volume 10 ; Issue 12 (2019)
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Spatially explicit analysis reveals complex human genetic gradients in the Iberian Peninsula
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| 8 |
Enrichment of genetic markers of recent human evolution in educational and cognitive traits.
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In: Scientific reports, vol 8, iss 1 (2018)
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
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In: Nature genetics, vol 50, iss 7 (2018)
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Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
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In: Twin research and human genetics : the official journal of the International Society for Twin Studies, vol 21, iss 5 (2018)
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| 11 |
Global genetic differentiation of complex traits shaped by natural selection in humans.
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In: Nature communications, vol. 9, no. 1, pp. 1865 (2018)
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.
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Trampush, JW; Yang, MLZ; Yu, J; Knowles, E; Davies, G; Liewald, DC; Starr, JM; Djurovic, S; Melle, I; Sundet, K; Christoforou, A; Reinvang, I; DeRosse, P; Lundervold, AJ; Steen, VM; Espeseth, T; Räikkönen, K; Widen, E; Palotie, A; Eriksson, JG; Giegling, I; Konte, B; Roussos, P; Giakoumaki, S; Burdick, KE; Payton, A; Ollier, W; Horan, M; Chiba-Falek, O; Attix, DK; Need, AC; Cirulli, ET; Voineskos, AN; Stefanis, NC; Avramopoulos, D; Hatzimanolis, A; Arking, DE; Smyrnis, N; Bilder, RM; Freimer, NA; Cannon, TD; London, E; Poldrack, RA; Sabb, FW; Congdon, E; Conley, ED; Scult, MA; Dickinson, D; Straub, RE; Donohoe, G; Morris, D; Corvin, A; Gill, M; Hariri, AR; Weinberger, DR; Pendleton, N; Bitsios, P; Rujescu, D; Lahti, J; Le Hellard, S; Keller, MC; Andreassen, OA; Deary, IJ; Glahn, DC; Malhotra, AK; Lencz, T
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In: Molecular psychiatry, vol 22, iss 3 (2017)
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Abstract:
The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~8M single-nucleotide polymorphisms (SNP) with minor allele frequency ⩾1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P<5 × 10-8). Gene-based analysis identified an additional three Bonferroni-corrected significant loci at chromosomes 17q21.31, 17p13.1 and 1p13.3. Altogether, common variation across the genome resulted in a conservatively estimated SNP heritability of 21.5% (s.e.=0.01%) for general cognitive function. Integration with prior GWAS of cognitive performance and educational attainment yielded several additional significant loci. Finally, we found robust polygenic correlations between cognitive performance and educational attainment, several psychiatric disorders, birth length/weight and smoking behavior, as well as a novel genetic association to the personality trait of openness. These data provide new insight into the genetics of neurocognitive function with relevance to understanding the pathophysiology of neuropsychiatric illness.
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Keyword:
Adult; Alleles; Biological Sciences; Cognition; European Continental Ancestry Group; Female; Gene Frequency; Genetic Association Studies; Genetic Loci; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Humans; Male; Medical and Health Sciences; Middle Aged; Multifactorial Inheritance; Neurocognitive Disorders; Polymorphism; Psychiatry; Psychology and Cognitive Sciences; Single Nucleotide
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URL: https://escholarship.org/uc/item/2qj7x9fw
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| 13 |
DISSECTING THE GENETICS OF HUMAN COMMUNICATION: INSIGHTS INTO SPEECH, LANGUAGE, AND READING
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In: http://rave.ohiolink.edu/etdc/view?acc_num=case1473337776061224 (2017)
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| 14 |
Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families.
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In: American journal of human genetics, vol 99, iss 3 (2016)
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Evaluation of results from genome-wide studies of language and reading in a novel independent dataset.
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| 16 |
Tumor size and survival in multicentric and multifocal breast cancer
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In: The Breast (2015)
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| 18 |
Aspects of speech-language abilities are influenced by MECP2 mutation type in girls with Rett syndrome
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In: Research outputs 2014 to 2021 (2015)
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Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study
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