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Development of a standard of care for patients with valosin-containing protein associated multisystem proteinopathy.
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In: Orphanet journal of rare diseases, vol 17, iss 1 (2022)
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Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation.
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In: Journal of neurodevelopmental disorders, vol 14, iss 1 (2022)
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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Knowledge and Attitudes towards Palliative Care: Validation of the Spanish Version of Questionnaire on Palliative Care for Advanced Dementia
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In: Healthcare; Volume 10; Issue 4; Pages: 656 (2022)
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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| 6 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults.
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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| 10 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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| 11 |
La lingüística clínica
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In: Revista Española de Lingüística, ISSN 2254-8769, Año nº 51, Fasc. 2, 2021, pags. 159-180 (2021)
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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| 13 |
Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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| 14 |
Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy.
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| 15 |
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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| 17 |
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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| 18 |
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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Boxer, Adam L; Gold, Michael; Feldman, Howard; Boeve, Bradley F; Dickinson, Susan L-J; Fillit, Howard; Ho, Carole; Paul, Robert; Pearlman, Rodney; Sutherland, Margaret; Verma, Ajay; Arneric, Stephen P; Alexander, Brian M; Dickerson, Bradford C; Dorsey, Earl Ray; Grossman, Murray; Huey, Edward D; Irizarry, Michael C; Marks, William J; Masellis, Mario; McFarland, Frances; Niehoff, Debra; Onyike, Chiadi U; Paganoni, Sabrina; Panzara, Michael A; Rockwood, Kenneth; Rohrer, Jonathan D; Rosen, Howard; Schuck, Robert N; Soares, Holly D; Tatton, Nadine
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Abstract:
IntroductionFrontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed.MethodsIn March 2018, the Association for Frontotemporal Degeneration convened the Frontotemporal Degeneration Study Group meeting in Washington, DC, to discuss advances in the clinical science of FTLD.ResultsChallenges exist for conducting clinical trials in FTLD. Two of the greatest challenges are (1) the heterogeneity of FTLD syndromes leading to difficulties in efficiently measuring treatment effects and (2) the rarity of FTLD disorders leading to recruitment challenges.DiscussionNew personalized endpoints that are clinically meaningful to individuals and their families should be developed. Personalized approaches to analyzing MRI data, development of new fluid biomarkers and wearable technologies will help to improve the power to detect treatment effects in FTLD clinical trials and enable new, clinical trial designs, possibly leveraged from the experience of oncology trials. A computational visualization and analysis platform that can support novel analyses of combined clinical, genetic, imaging, biomarker data with other novel modalities will be critical to the success of these endeavors.
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Keyword:
Acquired Cognitive Impairment; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); ARTFL; Atrophy; Biomarker; Biomarkers; Brain Disorders; C9orf72; Clinical Research; Clinical Sciences; Clinical trial; Clinical Trials and Supportive Activities; Clinical Trials as Topic; Congresses as Topic; Dementia; Frontotemporal dementia; Frontotemporal Dementia (FTD); Frontotemporal Lobar Degeneration; FTD; FTLD; Genetics; Geriatrics; GRN; Humans; LEFFTDS; Magnetic Resonance Imaging; MAPT; Neurodegenerative; Neurosciences; Primary progressive aphasia; Progressive supranuclear palsy; Rare Diseases
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URL: https://escholarship.org/uc/item/13t6f67b
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| 19 |
Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia.
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In: Brain : a journal of neurology, vol 143, iss 10 (2020)
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| 20 |
Comparing two facets of emotion perception across multiple neurodegenerative diseases.
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In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020)
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