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Evidence of the interplay of genetics and culture in Ethiopia. ...
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Evidence of the interplay of genetics and culture in Ethiopia. ...
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Evidence of the interplay of genetics and culture in Ethiopia ...
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Evidence of the interplay of genetics and culture in Ethiopia
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Evidence of the interplay of genetics and culture in Ethiopia.
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In: essn: 2041-1723 ; nlmid: 101528555 (2021)
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Evidence of the interplay of genetics and culture in Ethiopia
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In: Nat Commun (2021)
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Admixture into and within sub-Saharan Africa
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Busby, George BJ; Band, Gavin; Si Le, Quang; Jallow, Muminatou; Bougama, Edith; Mangano, Valentina; Amenga-Etego, Lucas; Enimil, Anthony; Apinjoh, Tobias; Ndila, Carolyne; Manjurano, Alphaxard; Nyirongo, Vysaul; Doumba, Ogobara; Rockett, Kirk; Kwiatkowski, Dominic; Spencer, Chris CA; Collaborators (273), Malaria Genomics Epidemiology Network
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In: ISSN: 2050-084X ; EISSN: 2050-084X ; eLife ; https://hal-pasteur.archives-ouvertes.fr/pasteur-02003953 ; eLife, eLife Sciences Publication, 2016, 5, pp.e15266. ⟨10.7554/eLife.15266⟩ (2016)
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Abstract:
International audience ; Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.
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Keyword:
[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]; [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]; [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics; [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]; [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; admixture; Africa; chromosome painting; evolutionary biology; gene-flow; genomics; human; MESH: Africa South of the Sahara; MESH: African Continental Ancestry Group; MESH: Gene Flow; MESH: Genetic Variation; MESH: Genome; MESH: Haplotypes; MESH: Human Migration; MESH: Humans
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URL: https://hal-pasteur.archives-ouvertes.fr/pasteur-02003953/file/elife-15266-v1.pdf
https://doi.org/10.7554/eLife.15266
https://hal-pasteur.archives-ouvertes.fr/pasteur-02003953
https://hal-pasteur.archives-ouvertes.fr/pasteur-02003953/document
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