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A novel image-based approach for interactive characterization of rock fracture spacing in a tunnel face
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Oral tribology: providing insight into oral processing of food colloids
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The trans-ancestral genomic architecture of glycemic traits
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Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M; Boutin, TS; Mägi, R; Waage, J; Li-Gao, R; Chan, KHK; Yao, J; Anasanti, MD; Chu, AY; Claringbould, A; Heikkinen, J; Hong, J; Hottenga, J-J; Huo, S; Kaakinen, MA; Louie, T; März, W; Moreno-Macias, H; Ndungu, A; Nelson, SC; Nolte, IM; North, KE; Raulerson, CK; Ray, D; Rohde, R; Rybin, D; Schurmann, C; Sim, X; Southam, L; Stewart, ID; Wang, CA; Wang, Y; Wu, P; Zhang, W; Ahluwalia, TS; Appel, EVR; Bielak, LF; Brody, JA; Burtt, NP; Cabrera, CP; Cade, BE; Chai, JF; Chai, X; Chang, L-C; Chen, C-H; Chen, BH; Chitrala, KN; Chiu, Y-F; de Haan, HG; Delgado, GE; Demirkan, A; Duan, Q; Engmann, J; Fatumo, SA; Gayán, J; Giulianini, F; Gong, JH; Gustafsson, S; Hai, Y; Hartwig, FP; He, J; Heianza, Y; Huang, T; Huerta-Chagoya, A; Hwang, MY; Jensen, RA; Kawaguchi, T; Kentistou, KA; Kim, YJ; Kleber, ME; Kooner, IK; Lai, S; Lange, LA; Langefeld, CD; Lauzon, M; Li, M; Ligthart, S; Liu, J; Loh, M; 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Abstract:
This is the author accepted manuscript. The final version is available from nature Research via the DOI in this record ; Note: There are differences between the text of the author accepted manuscript in this record and that of the final published version. this is due to a large number of textual changes and cuts made by the authors after official final acceptance, at the request of the journal editorial office. ; Code availability: Source code implementing the methods described in the paper are publicly available at https://doi.org/10.5281/zenodo.4607311. ; Data availability: Ancestry-specific and overall meta-analysis summary level results are available through the MAGIC website (https://www.magicinvestigators.org/). Summary statistics are also available through the GWAS catalog (https://www.ebi.ac.uk/gwas/) with the following accession codes: GCST90002225, GCST90002226, GCST90002227, GCST90002228, GCST90002229, GCST90002230, GCST90002231, GCST90002232, GCST90002233, GCST90002234, GCST90002235, GCST90002236, GCST90002237, GCST90002238, GCST90002239, GCST90002240, GCST90002241, GCST90002242, GCST90002243, GCST90002244, GCST90002245, GCST90002246, GCST90002247 and GCST90002248. ; Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.
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URL: https://doi.org/10.1038/s41588-021-00852-9
http://hdl.handle.net/10871/125997
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The trans-ancestral genomic architecture of glycemic traits.
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The trans-ancestral genomic architecture of glycemic traits.
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In: Nature genetics, vol. 53, no. 6, pp. 840-860 (2021)
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A Counter-Reformation Reaction to Slovenian and Croatian Protestantism: The Symbol of St. Athanasius in a Creed of 1624
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Cavallini Ivano. - : Hollitzer Verlag, 2018. : country:AT, 2018. : place:Vienna, 2018
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Promises and lies: Can observers detect deception in written messages
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ASPIRE: A multi-site community-based participatory research project to increase understanding of the dynamics of violence against immigrant and refugee women in Australia
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ASPIRE: A multi-site community-based participatory research project to increase understanding of the dynamics of violence against immigrant and refugee women in Australia
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Semantic Modelling with Long-Short-Term Memory for Information Retrieval ...
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Age of language learning shapes brain structure: A cortical thickness study of bilingual and monolingual individuals
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