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Study of central exclusive [Image: see text] production in proton-proton collisions at [Formula: see text] and 13TeV
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In: Eur Phys J C Part Fields (2020)
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A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
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A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
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Treating conduct disorder: An effectiveness and natural language analysis study of a new family-centred intervention program
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In: Stevens, KA, Ronan, K, Davies, G. (2017). Treating conduct disorder: An effectiveness and natural language analysis study of a new family-centred intervention program. Psychiatry Research, Vol. 251, p. 287-293 http://dx.doi.org/10.1016/j.psychres.2016.11.035 (2017)
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.
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In: Molecular psychiatry, vol 22, iss 3 (2017)
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Gwas meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the cogent consortium
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Search for dark matter produced in association with heavy-flavor quark pairs in proton-proton collisions at [Formula: see text]
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
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Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)
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Davies, G; Marioni, R E; Liewald, D C; Hill, W D; Hagenaars, S P; Harris, S E; Ritchie, S J; Luciano, M; Fawns-Ritchie, C; Lyall, D; Cullen, B; Cox, S R; Hayward, C; Porteous, D J; Evans, J; McIntosh, A M; Gallacher, J; Craddock, N; Pell, J P; Smith, D J; Gale, C R; Deary, I J. - : Nature Publishing Group, 2016
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Abstract:
People's differences in cognitive functions are partly heritable and are associated with important life outcomes. Previous genome-wide association (GWA) studies of cognitive functions have found evidence for polygenic effects yet, to date, there are few replicated genetic associations. Here we use data from the UK Biobank sample to investigate the genetic contributions to variation in tests of three cognitive functions and in educational attainment. GWA analyses were performed for verbal–numerical reasoning (N=36 035), memory (N=112 067), reaction time (N=111 483) and for the attainment of a college or a university degree (N=111 114). We report genome-wide significant single-nucleotide polymorphism (SNP)-based associations in 20 genomic regions, and significant gene-based findings in 46 regions. These include findings in the ATXN2, CYP2DG, APBA1 and CADM2 genes. We report replication of these hits in published GWA studies of cognitive function, educational attainment and childhood intelligence. There is also replication, in UK Biobank, of SNP hits reported previously in GWA studies of educational attainment and cognitive function. GCTA-GREML analyses, using common SNPs (minor allele frequency>0.01), indicated significant SNP-based heritabilities of 31% (s.e.m.=1.8%) for verbal–numerical reasoning, 5% (s.e.m.=0.6%) for memory, 11% (s.e.m.=0.6%) for reaction time and 21% (s.e.m.=0.6%) for educational attainment. Polygenic score analyses indicate that up to 5% of the variance in cognitive test scores can be predicted in an independent cohort. The genomic regions identified include several novel loci, some of which have been associated with intracranial volume, neurodegeneration, Alzheimer's disease and schizophrenia.
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Keyword:
Immediate Communication
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879186/ http://www.ncbi.nlm.nih.gov/pubmed/27046643 https://doi.org/10.1038/mp.2016.45
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Examining non-syndromic autosomal recessive intellectual disability (NS-ARID) genes for an enriched association with intelligence differences
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Genetic contributions to variation in general cognitive function: A meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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GWAS-based pathway analysis differentiates between fluid and crystallized intelligence
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Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.
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In: Mol Psychiatry , 19 (2) 253 - 258. (2014) (2014)
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Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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Genetic copy number variation and general cognitive ability.
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In: PLoS One , 7 (12) , Article e37385 . (2012) (2012)
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