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Study of central exclusive [Image: see text] production in proton-proton collisions at [Formula: see text] and 13TeV
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In: Eur Phys J C Part Fields (2020)
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A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
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A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
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Treating conduct disorder: An effectiveness and natural language analysis study of a new family-centred intervention program
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In: Stevens, KA, Ronan, K, Davies, G. (2017). Treating conduct disorder: An effectiveness and natural language analysis study of a new family-centred intervention program. Psychiatry Research, Vol. 251, p. 287-293 http://dx.doi.org/10.1016/j.psychres.2016.11.035 (2017)
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.
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In: Molecular psychiatry, vol 22, iss 3 (2017)
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Gwas meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the cogent consortium
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Search for dark matter produced in association with heavy-flavor quark pairs in proton-proton collisions at [Formula: see text]
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
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Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)
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Examining non-syndromic autosomal recessive intellectual disability (NS-ARID) genes for an enriched association with intelligence differences
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Genetic contributions to variation in general cognitive function: A meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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GWAS-based pathway analysis differentiates between fluid and crystallized intelligence
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Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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Benyamin, B.; St Pourcain, B.; Davis, O.; Davies, G.; Hansell, N.; Brion, M.; Kirkpatrick, R.; Cents, R.; Franic, S.; Miller, M.; Haworth, C.; Meaburn, E.; Price, T.; Evans, D.; Timpson, N.; Kemp, J.; Ring, S.; McArdle, W.; Medland, S.; Yang, J.. - : Nature Publishing Group, 2014
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Abstract:
Intelligence in childhood, as measured by psychometric cognitive tests, is a strong predictor of many important life outcomes, including educational attainment, income, health and lifespan. Results from twin, family and adoption studies are consistent with general intelligence being highly heritable and genetically stable throughout the life course. No robustly associated genetic loci or variants for childhood intelligence have been reported. Here, we report the first genome-wide association study (GWAS) on childhood intelligence (age range 6–18 years) from 17 989 individuals in six discovery and three replication samples. Although no individual single-nucleotide polymorphisms (SNPs) were detected with genome-wide significance, we show that the aggregate effects of common SNPs explain 22–46% of phenotypic variation in childhood intelligence in the three largest cohorts (p=3.9 × 10‾⁵, 0.014 and 0.028). FNBP1L, previously reported to be the most significantly associated gene for adult intelligence, was also significantly associated with childhood intelligence (p=0.003). Polygenic prediction analyses resulted in a significant correlation between predictor and outcome in all replication cohorts. The proportion of childhood intelligence explained by the predictor reached 1.2% (p=6 × 10‾⁵), 3.5% (p=10‾³) and 0.5% (p=6 × 10‾⁵) in three independent validation cohorts. Given the sample sizes, these genetic prediction results are consistent with expectations if the genetic architecture of childhood intelligence is like that of body mass index or height. Our study provides molecular support for the heritability ; B Benyamin, BSt Pourcain, OS Davis, G Davies, NK Hansell, M-JA Brion, RM Kirkpatrick, RAM Cents, S Franic, MB Miller, CMA Haworth, E Meaburn, TS Price, DM Evans, N Timpson, J Kemp, S Ring, W McArdle, SE Medland, J Yang, SE Harris, DC Liewald, P Scheet, X Xiao, JJ Hudziak, EJC de Geus, Wellcome Trust Case Control Consortium, WTCCC, VWV Jaddoe, JM Starr, FC Verhulst, C Pennell, H Tiemeier, WG Iacono, LJ Palmer, GW Montgomery, NG Martin, DI Boomsma, D Posthuma, M McGue, MJ Wright, G Davey Smith, IJ Deary, R Plomin, and PM Visscher
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Keyword:
association; cognitive; FNBP1L; Intelligence; IQ; polygenic
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URL: https://doi.org/10.1038/mp.2012.184 http://hdl.handle.net/2440/88219
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.
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In: Mol Psychiatry , 19 (2) 253 - 258. (2014) (2014)
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Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins
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BASE
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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Genetic copy number variation and general cognitive ability.
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In: PLoS One , 7 (12) , Article e37385 . (2012) (2012)
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