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C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.
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In: Neurology, vol 95, iss 24 (2020)
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C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts
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C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts
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In: Neurology (2020)
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Effect of functional BDNF and COMT polymorphisms on symptoms and regional brain volume in Frontotemporal Dementia and Corticobasal Syndrome
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In: J Neuropsychiatry Clin Neurosci (2020)
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C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts
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Distributed neural system for emotional intelligence revealed by lesion mapping
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Characterizing discourse deficits following penetrating head injury: A preliminary model
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In: Am J Speech Lang Pathol (2013)
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An integrative architecture for general intelligence and executive function revealed by lesion mapping
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Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
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Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
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Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
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Frontotemporal Dementia Selectively Impairs Transitive Reasoning About Familiar Spatial Environments
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Abstract:
Although patients with frontotemporal dementia (FTD) are known to exhibit a wide range of cognitive and personality difficulties, some evidence suggests that there may be a degree of selectivity in their reasoning impairments. Based on a recent review of the neuroimaging literature on reasoning, the authors hypothesized that the presence or absence of familiar content may have a selective impact on the reasoning abilities of patients with FTD. Specifically, the authors predicted that patients with frontalvariant FTD would be more impaired when reasoning about transitive arguments involving familiar spatial environments than when reasoning about identical logical arguments involving unfamiliar spatial environments. As predicted, patients with FTD were less accurate than normal controls only when the content of arguments involved familiar spatial environments. These results indicate a degree of selectivity in the cognitive deficits of this patient population and suggest that the frontal-temporal lobe system may play a necessary role in reasoning about familiar material.
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Article
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981035 http://www.ncbi.nlm.nih.gov/pubmed/19702415 https://doi.org/10.1037/a0015810
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Language Impairment Associated with Lesions to Dorsolateral Prefrontal Cortex: Dynamic Aphasia?
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