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1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
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Mediated phonological–semantic priming in spoken word production: Evidence for cascaded processing from picture–word interference ...
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Mediated phonological–semantic priming in spoken word production: Evidence for cascaded processing from picture–word interference ...
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Top-down resolution of lexico-semantic competition in speech production and the role of the left inferior frontal gyrus: an fMRI study ...
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Top-down resolution of lexico-semantic competition in speech production and the role of the left inferior frontal gyrus: an fMRI study ...
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Alterations to dual stream connectivity predicts response to aphasia therapy following stroke
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Abstract:
Background: Predicting aphasia recovery is difficult due to a high variability in treatment response. Detailed measures of treatment response are compounded by a dearth of information that examine brain connections that contribute to clinical improvement. In this study we measure alterations to cortical connectivity pathways during a therapy paradigm to detect whether key brain connections that contribute to language recovery can be detected prior to therapy. Methods: We conducted a case-control trial with twenty-three adults including eight adults with chronic, post-stroke aphasia. Aphasia patients underwent 12 naming therapy sessions over 4 weeks, consisting of semantic and phonological treatment approaches. High-density electroencephalography (128 channel EEG) was measured prior to therapy and immediately following treatment in patients with aphasia. Analysis via a dynamic causal modelling (DCM) was used to assess which cortical connections significantly correlated with therapy response. Results: Altered cortical responses in aphasia patients measured bilaterally in a dual stream DCM connectivity model were predictive of treatment-induced improvement in naming. Pre-treatment DCM coupling (i.e., strength of cortical connections) significant correlated with naming improvement for items treated with semantic therapy, as indicated by increased connection strengths between left inferior parietal lobule (LIPL) and inferior frontal gyrus (LIFG, r = .63, p FDR = .016). In particular, the mediating role of contralateral regions significantly influences overall treatment improvement in the latter stages of stroke recovery. Conclusions: Our findings identify a potential means to stratify larger cohorts of patients in neurorehabilitation settings into distinct treatments that are tailored to their individual language deficit.
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Keyword:
dynamic causal modelling; hight-density EEG; naming treatment; post-stroke aphasia; stroke recovery
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URL: http://hdl.handle.net/1959.13/1426690
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The influence of contextual constraint on verbal selection mechanisms and its neural correlates in Parkinson’s disease
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Alterations to dual stream connectivity predicts response to aphasia therapy following stroke
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Top-down resolution of lexico-semantic competition in speech production and the role of the left inferior frontal gyrus: an fMRI study
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The Suppression of Irrelevant Semantic Representations in Parkinson’s Disease
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The shape of things to come in speech production: a functional magnetic resonance imaging study of visual form interference during lexical access
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Functional correlates of strategy formation and verbal suppression in Parkinson's disease
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Neural mechanisms for monitoring and halting of spoken word production
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Brain activity during spoken word recognition in subacute aphasia
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The suppression of irrelevant semantic representations in Parkinson's Disease
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The shape of things to come in speech production: visual form interference during lexical access
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No lexical competition without priming: evidence from the picture–word interference paradigm
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Predicting language difficulties in middle childhood from early developmental milestones: a comparison of traditional regression and machine learning techniques
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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
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In: ISSN: 1931-7557 ; EISSN: 1931-7565 ; Brain imaging and behavior (Brain Imaging Behav) ; https://hal.archives-ouvertes.fr/hal-01382787 ; Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, 2017, 11 (5), pp.1497-1514. ⟨10.1007/s11682-016-9629-z⟩ (2017)
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Novel genetic loci associated with hippocampal volume
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In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-01488337 ; Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩ (2017)
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